DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MEP-1 and Zfp687

DIOPT Version :9

Sequence 1:	NP_001137875.1	Gene:	MEP-1 / 38327	FlyBaseID:	FBgn0035357	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_001344792.1	Gene:	Zfp687 / 78266	MGIID:	1925516	Length:	1237	Species:	Mus musculus

Alignment Length:	1316	Identity:	238/1316 - (18%)
Similarity:	367/1316 - (27%)	Gaps:	502/1316 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 ADEIMEVDGTEDVEENEVENDDEDSQITSSSSKEPKL--DEEDEEATTNGDGDHEPEDEDDAQKI 157
            |.:|.::|..|.:.....||:....|    ...||.:  |.:|.|.....:.|.|...|.....:
Mouse    15 AFDIPDIDANEAIHSGPEENEGPGGQ----GKPEPSVGGDSKDREEAAAAENDPESPAEASDHGL 75

  Fly   158 GSTAENSCEAEDPLGAVTVPDDELASGKKAHLDGEESVASEGVVEEEPPAK--QENGFGA-SPNQ 219
            ....:.|..:......|.....|..:|.    .|||...:.|:.:|.|...  .:||||. .|:.
Mouse    76 PQPPDTSTVSVIVKNTVCPEQSESLTGD----SGEEETKAGGITKEGPVGSCLMQNGFGGPEPSL 136

  Fly   220 KENGQASIAEARAAIAPSDGGVVNLDEDSDEEMEDIT-------------EHKEPAKPTEKAAKP 271
            .||..:|        |.:.|...     .|:.:|..|             :|.:|..|     :|
Mouse   137 SENPHSS--------AHASGNAW-----KDKAVEGKTCLDLFAHFGSEPGDHPDPLPP-----EP 183

  Fly   272 ASSSGGESSDDAVLIASDSDTESAAPPP---PVKKLPPVVKAIPPPPVQDDEDDDDDDDCVVIED 333
            :...||:                .||||   |.:..|.....:.|
Mouse   184 SQPRGGD----------------MAPPPFSTPFELAPENGSTLLP-------------------- 212

  Fly   334 DTPLSISPSGKRKSDLDDLQLQQPSHKRQRSSTPSGMGQLTIKDARSLMPLDGSPSSVSGPRDSI 398
              |.|:.|.|..|               |.|.:|.....||.:...|.....|.|:|||.|:
Mouse   213 --PASLLPQGALK---------------QESCSPHHSQGLTQRGPGSSPETAGIPASVSPPQ--- 257

  Fly   399 YPVTITNAVTGAATNLGVVPPKLVPMAGGMSASPVQLNPPTLSLTGLPSMTNNANLLPGLTDDMF 463
                    |.|.:                ...||...:||...
Mouse   258 --------VAGVS----------------FKQSPGHQSPPASP---------------------- 276

  Fly   464 VLEAPSFIVPYIYEKPPRENICEVVKAIETKYALSAEDLAEADKGDEFDMMTEQNKEDKPADQAD 528
             ::|||               |:.:|              |.|:|       ..:|....:.|:.
Mouse   277 -VKAPS---------------CKPLK--------------EEDEG-------TVDKSPPRSPQSP 304

  Fly   529 ESGKKKKKKRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLIKEAN------------------- 574
            .||              .::.|:|..|....|.|....||.||...
Mouse   305 SSG--------------AEAADEDSNDSPTSSSSSRPLKVRIKTIKTSCGNITRTVTRVPSEPDP 355

  Fly   575 -----------------------------------DDLSALKVAIKPAAAL----------ATAG 594
                                               .|.:.||..:.|.|.:          |:..
Mouse   356 PAPLAEGAFLAETSFLKLSPVTPTPEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVA 420

  Fly   595 GVSVNNPGGNKPGQENYFESPLG-------KFFMDIGVGLVQEYVQ-SDLLRLQKRK-------- 643
            ..:|..||||....:...:|.||       |..:..|..|..:.|. :.::.:|..|
Mouse   421 RKAVVLPGGNATSPKTMTKSVLGLVPQTLPKAEVRTGFSLGGQKVNGASVVMVQPSKSATGPGTA 485

  Fly   644 ----MRKAQVQNSKEFEMAINALSGNLQASKTKN-----------APFKFRMKRCEFCNFKSESA 693
                :.:.|....:.|...:|  |.||..:...|           .|..:   ||..|.......
Mouse   486 GGSVISRTQSSLVEAFNKILN--SKNLLPAYRPNLSPPAEAGLALPPTGY---RCLECGDAFSLE 545

  Fly   694 MAMANHYETPHMNGVLYKCNFCTFEI--RNATEIVYHMEAVHNIKARLIKPLPYHQCPNCGFEDN 756
            .::|.||:...|. :...||.|...:  .|...::.|... |..|..::      ||.:....
Mouse   546 KSLARHYDRRSMR-IEVTCNHCARRLVFFNKCSLLLHARE-HKDKGLVM------QCSHLVMR-- 600

  Fly   757 GKAKLARHQPVCAKKFRPELNLAPPNDWEAPAKIPRIKPRHGLVGTATAYQAMAAQA-------- 813
               .:|..|.|......|.|.:|.| ....|..:|.:....|.| |::....:|.:|
Mouse   601 ---PVALDQMVGQPDITPLLPVAVP-PVPGPLALPVLGKGEGAV-TSSTITTVATEAPVLPLPTE 660

  Fly   814 ---------------------AAQKAALANIQQQ---QAAAQARNNLQAAALAAQNAAKMRQRAP 854
                                 ...||.:|...||   .|.....|...:..:...|....  .|.
Mouse   661 PPAPPTASVYTCFRCLECKEQCRDKAGMAAHFQQLGPPALGSTSNVCPSCPMMLPNRCSF--SAH 723

  Fly   855 QPPKQNIVRNPAPVRGGNAMNA-----------------GLSLPNSYQLAAG-----QLVQAS-- 895
            |...:|...:..|..|||.:.|                 |...|:...:..|     ..:|||
Mouse   724 QRTHKNRAPHVCPECGGNFLQANFQTHLREACLHFSRRVGYRCPSCAVVFGGVNSIKSHIQASHC 788

  Fly   896 ----KKPMAGQPSISITPLPRQSSVGAGAGASSSKAPQAAAGMKPGQSPSG-NNKAQFVI-CEIC 954
                |.|        |.|:..:|            ||.|.|.:. .|.||. ..:|:.:. |.:|
Mouse   789 EVFHKCP--------ICPMAFKS------------APSAHAHLY-SQHPSFLTQQAKLIYKCAMC 832

  Fly   955 DGYIKDLEQLRNHMQWMHKVKIHPKMIYNRPPLNCQKCQFRFFTDQGLERHLLGSH--------- 1010
            |........|.:|.. .|   :.|:.:   ....|..|...|...:.:..||..:|
Mouse   833 DTVFTHKPLLSSHFD-QH---LLPQRV---SVFKCPSCPLLFAQKRTMLEHLKNTHQSGRVGEEA 890

  Fly  1011 -------GLVTS---------SMQEAA---------------------------------NKG-K 1025
                   .|:|.         |..|||                                 ||| |
Mouse   891 VGKGAGGALLTPKTEPEELAVSQAEAAPATEESSSSSEEELPSSPEPPRPTKRARRGELGNKGIK 955

  Fly  1026 DAGRCP---VCGRMYQW-----KLLNHVSRDHHMTLKPAHLSYKCTVCTATFGMYKQFETHVYTA 1082
            ..|..|   .||..:.|     :.:.|:.::|..::|    .:.|.:|..:|........||...
Mouse   956 GGGGGPGGWTCGLCHSWCPERDEYVTHMKKEHGKSVK----KFPCRLCERSFCSAPSLRRHVRVN 1016

  Fly  1083 HSTV-----ARKAMDSKKNSAQ-----------------SSGSGSGAGMSRSSLGAANDSLLKPL 1125
            |..:     .|...:.|:..:.                 :..||.|..::|.|.|.|.....|..
Mouse  1017 HEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLPLGTQSSGRGGSLARGSGGRAQGPGRKRR 1081

  Fly  1126 KINDEITIIPQPASKP 1141
            :.:|..:..|...:.|
Mouse  1082 QSSDSCSEEPDSTTPP 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEP-1	NP_001137875.1	BSP_II	<121..>226	CDD:283165	25/109 (23%)
		C2H2 Zn finger	951..977	CDD:275371	6/25 (24%)
		C2H2 Zn finger	989..1010	CDD:275371	5/20 (25%)
Zfp687	NP_001344792.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..151		35/151 (23%)
		PHA03307	30..>281	CDD:223039	71/379 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..331		54/325 (17%)
		PHA03247	<169..532	CDD:223021	85/522 (16%)
		C2H2 Zn finger	707..727	CDD:275368	3/21 (14%)
		C2H2 Zn finger	735..757	CDD:275368	5/21 (24%)
		zf-C2H2_8	795..877	CDD:406359	22/109 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..957		11/77 (14%)
		C2H2 Zn finger	966..986	CDD:275368	4/19 (21%)
		C2H2 Zn finger	996..1017	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1026..1046	CDD:275368	2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1052..1117		11/46 (24%)
		zf-C2H2_11	1131..1159	CDD:406917
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1166..1195
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I5013
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050