DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MEP-1 and ZFY

DIOPT Version :9

Sequence 1:	NP_001137875.1	Gene:	MEP-1 / 38327	FlyBaseID:	FBgn0035357	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_001356631.1	Gene:	ZFY / 7544	HGNCID:	12870	Length:	801	Species:	Homo sapiens

Alignment Length:	1104	Identity:	186/1104 - (16%)
Similarity:	324/1104 - (29%)	Gaps:	441/1104 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 EDVAQASPQAP------VADEIMEVDGTEDVEE--------NEVEN---------DDEDSQITSS 124
            ||..:..||.|      :..:...:||.:.|.|        |.|::         ||.||.:...
Human     3 EDEFELQPQEPNSFFDGIGADATHMDGDQIVVEIQEAVFVSNIVDSDITVHNFVPDDPDSVVIQD 67

  Fly   125 SSKEPKLDE--------EDEEATTNGDGDHEPEDEDDAQKIGSTAENSCEAEDPLGAVTVPDDEL 181
            ..::..::|        |:.:.:.|.....:..|.|..:::.            |...|||||.|
Human    68 VVEDVVIEEDVQCSDILEEADVSENVIIPEQVLDSDVTEEVS------------LPHCTVPDDVL 120

  Fly   182 ASGKKAHLDGEESVASEGVVEEEPPAKQENGFGASPNQKENGQASIAEARAAIAPSDGGVVNLDE 246
            ||          .:.|..:...|.....|:             ..:.:.        |.|.::..
Human   121 AS----------DITSTSMSMPEHVLTSES-------------MHVCDI--------GHVEHMVH 154

  Fly   247 DSDEEMEDITEHKEPAKPTEKAAKPASSSGGESSDDAVLIASDSDTESAAPPPPVKKLPPVVKAI 311
            ||..|.|.||:             |.:|   :...:.||:|      ..||.          ..|
Human   155 DSVVEAEIITD-------------PLTS---DIVSEEVLVA------DCAPE----------AVI 187

  Fly   312 PPPPVQDDEDDDDDDDCVVIEDDTPLSISPSGKRKSDLDDLQLQQPSHKRQRSSTPSGMGQLTIK 376
            ....:..|:.|:|...|   ||...:|:..:||.:.|                    |...:||
Human   188 DASGISVDQQDNDKASC---EDYLMISLDDAGKIEHD--------------------GSTGVTI- 228

  Fly   377 DARSLMPLDGSPSSVSGPRDSIYPVTITNAVTGAATNLGVVPPKLVPMAGGMSASPVQLNPPTLS 441
            ||.|                                                     :::|..:.
Human   229 DAES-----------------------------------------------------EMDPCKVD 240

  Fly   442 LTGLPSMTNNANLLPGLTDDMFVLEAPSFIVPYIYEKPPRENICEVVKAIETKYALSAEDLAEAD 506
            .|                       .|..|..||::..|.|:                      |
Human   241 ST-----------------------CPEVIKVYIFKADPGED----------------------D 260

  Fly   507 KGDEFDMMTEQNKEDKPADQADESGKKKKKKRGDDESWSEQSDDDDDEDDDD----DSESGVRTK 567
            .|...|::..:.:.|...:..|::...:..:    |.....:.:|..::|:|    :....|..:
Human   261 LGGTVDIVESEPENDHGVELLDQNSSIRVPR----EKMVYMTVNDSQQEDEDLNVAEIADEVYME 321

  Fly   568 VLIKEANDDLSALKVAI----------KPAAALATAGGVSVNNPGGNKPGQENYFESPLGKFFMD 622
            |::.|.:..::|...|:          |....:|.|...     |.|..|.||...:......:|
Human   322 VIVGEEDAAVAAAAAAVHEQQIDEDEMKTFVPIAWAAAY-----GNNSDGIENRNGTASALLHID 381

  Fly   623 IGVGLVQEYVQSDLLRLQKRKMRKAQVQNSKEFEMAI-------------NALSGNLQASK---- 670
            ...||.         ||.|:|.:|.:..:|::::.||             ..:.|....|:
Human   382 ESAGLG---------RLAKQKPKKKRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLK 437

  Fly   671 --TKNAPFKFRMKR--CEFCNFKSESAMAMANHYETPHMN-------------------GVLY-- 710
              .||.|.....|:  |..|::.:...:::.||.|:..:.                   |.|:
Human   438 RHMKNHPEHLAKKKYHCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTH 502

  Fly   711 -------------KCNFCTFEIRNATEIVYHMEAVHNIKARLIKPLPYHQCPNCGFEDNGKAKLA 762
                         ||.||.:|......:..|:.|||:      |..| |.|..||......::|.
Human   503 KMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHS------KNFP-HICVECGKGFRHPSELR 560

  Fly   763 RHQPVCAKKFRPELNLAPPNDWEAPAKIPRIKPRHGLVGTATAYQAMAAQAAAQKAALANIQQQQ 827
            :|..:              :..|.|                  ||....:  .:.|..:|::..
Human   561 KHMRI--------------HTGEKP------------------YQCQYCE--YRSADSSNLKTH- 590

  Fly   828 AAAQARNNLQAAALAAQNAAKMRQRAPQPPKQNIVRNPAPVRGGNAMNAGLSLPNSYQLAAGQLV 892
                               .|.:.....|.|.:|..              |:..::.::....||
Human   591 -------------------IKTKHSKEMPFKCDICL--------------LTFSDTKEVQQHTLV 622

  Fly   893 QASKKPMAGQPSISITPLPRQSSVGAGAGASSSKAPQAAAGMKPGQSPSGNNKAQFVICEICDGY 957
            ....|      :........:||       :||...:....:.....|..        ||:|:..
Human   623 HQESK------THQCLHCDHKSS-------NSSDLKRHVISVHTKDYPHK--------CEMCEKG 666

  Fly   958 IKDLEQLRNHMQWMHK-VKIHPKMIYNRPPLNCQKCQFRFFTDQGLERHLLGSHGLVTSSMQEAA 1021
            .....:|:.|:. :|| .|:|          .|:.|.|:......|.||:|..|
Human   667 FHRPSELKKHVA-VHKGKKMH----------QCRHCDFKIADPFVLSRHILSVH----------- 709

  Fly  1022 NKGKDAG-RCPVCGRMYQWKLLNHVSRDHHMTLKPAHLSYKCTVCTATFGMYKQFETHVYTAHS 1084
              .||.. ||..|.:.::.:  |.:.:  ||........|:|..|..:......|:.||.:.|:
Human   710 --TKDLPFRCKRCRKGFRQQ--NELKK--HMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHT 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEP-1	NP_001137875.1	BSP_II	<121..>226	CDD:283165	17/112 (15%)
		C2H2 Zn finger	951..977	CDD:275371	8/26 (31%)
		C2H2 Zn finger	989..1010	CDD:275371	7/20 (35%)
ZFY	NP_001356631.1	Zfx_Zfy_act	71..406	CDD:309717	88/549 (16%)
		COG5048	<417..592	CDD:227381	36/235 (15%)
		C2H2 Zn finger	423..443	CDD:275368	3/19 (16%)
		C2H2 Zn finger	454..478	CDD:275368	5/23 (22%)
		C2H2 Zn finger	486..506	CDD:275368	2/19 (11%)
		COG5048	539..>676	CDD:227381	31/232 (13%)
		C2H2 Zn finger	546..566	CDD:275368	5/33 (15%)
		zf-H2C2_2	558..582	CDD:338759	6/57 (11%)
		C2H2 Zn finger	574..593	CDD:275368	2/40 (5%)
		C2H2 Zn finger	603..652	CDD:275368	9/75 (12%)
		C2H2 Zn finger	660..680	CDD:275368	5/20 (25%)
		zf-C2H2	715..737	CDD:333835	6/25 (24%)
		C2H2 Zn finger	717..737	CDD:275368	5/23 (22%)
		zf-H2C2_2	729..753	CDD:338759	5/25 (20%)
		C2H2 Zn finger	745..766	CDD:275368	5/20 (25%)
		C2H2 Zn finger	774..794	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100