DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MEP-1 and Zfp316

DIOPT Version :9

Sequence 1:	NP_001137875.1	Gene:	MEP-1 / 38327	FlyBaseID:	FBgn0035357	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_059495.3	Gene:	Zfp316 / 54201	MGIID:	1860402	Length:	1017	Species:	Mus musculus

Alignment Length:	1079	Identity:	205/1079 - (18%)
Similarity:	310/1079 - (28%)	Gaps:	416/1079 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 PAKQENGFGASPNQKENGQASIAEARAAIAPSDGGVVNLDEDSDEEMEDITEHKEPAKPTEKAAK 270
            ||:..:...|.|.::|..:.                   .|:.|||.|:....:|.|.|.::.|:
Mouse    18 PAEDGSECDADPEEEEEEEQ-------------------QEEEDEEEEEEVVVEEVATPVQEVAE 63

  Fly   271 ------PASSSGGESSDDAVLIASDSDTESAAPPPPVKKL-------------PPVV--KAIPP- 313
                  .|.:.||:..||..  ..|.|.|..........|             .||:  ||:..
Mouse    64 VEVEANSADNGGGDDDDDGG--GGDDDVEEVLAEEQTLSLGTQERHSNGGHAKAPVLQGKALQTS 126

  Fly   314 --PPVQDDEDDDDDDDCVVIEDDTPLSISPSGKRKSDLDDLQLQQPSHKRQRSSTPSGMGQLTIK 376
              .|...|||.:::::    |:|               ::..|.|              |.:|.:
Mouse   127 RVSPTTQDEDVEEEEE----EED---------------EEHFLTQ--------------GLVTFE 158

  Fly   377 DARSLMPLDGSPSSVSGPRDSIYPVTITNAVTGAATNLGVVPPKLVPMAGGMSASPVQLNPPTLS 441
            |......|:.........||....|...|  .|...:||...||
Mouse   159 DVAVYFSLEEWERLGVDQRDLYREVMQEN--YGILVSLGYPIPK--------------------- 200

  Fly   442 LTGLPSMTNNANLLPGLTDDMFVLEAPSFIVPYIYEKP-PRENICEVVKAIETKYALSAEDLAEA 505
                             .|.:|.||...  .|::.:.| |.|.  :||..:.|
Mouse   201 -----------------PDLIFHLEQGE--EPWVEDGPHPEEG--DVVTGVYT------------ 232

  Fly   506 DKGDEFDMMTEQNKEDKPADQADESGKKKKKKRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLI 570
              |..|                                |::..:|.::|||:|         .|.
Mouse   233 --GAWF--------------------------------WNDDIEDHEEEDDED---------FLA 254

  Fly   571 KEANDDLSALKVAIKPAAALATAGGVSVNNPGGNKPGQENYFESPLGKFFMDIGVGLVQEYVQS- 634
            :.|.::       .:|....:.|.||. :.||...|...:..::|.|.......:|::.|.|::
Mouse   255 EVAEEE-------NEPPGLWSAAYGVG-DVPGTWGPDDSDSVQTPEGWGPNPGSLGILAEEVEAK 311

  Fly   635 --------------------------------DLL--------RLQKRKMRKAQV------QNSK 653
                                            |:.        ||.|.:...|.|      :..|
Mouse   312 HFLSGREPGENFLVPWAFPAVAVPIGCPETTCDVCGKVFPHRSRLAKHQRYHAAVKPFGCDECGK 376

  Fly   654 EF----EMAINALSGNLQASKTKNAPF-------KF----------------RMKRCEFCNFKSE 691
            .|    .:||:      |.:.|...||       :|                |..||.||.....
Mouse   377 GFVYRSHLAIH------QRTHTGEKPFPCPDCGKRFVYKSHLVTHRRIHTGERPYRCVFCGAGFG 435

  Fly   692 SAMAMANHYETPHMNGVLYKCNFCTFEIRNATEIVYHMEAVHNIKARLIKPLPYHQCPNCGFEDN 756
            ....:..|..| |.....|.|..|......::.:..| :|||...    :|   |.||:||....
Mouse   436 RRSYLVTHQRT-HTGERPYPCLHCGRSFSQSSALARH-QAVHTAD----RP---HCCPDCGQAFR 491

  Fly   757 GKAKLARHQPV--CAK-------KFRP-ELNLAPPNDWEAPAKIPRIKPRHGLVGTATAYQAMAA 811
            .:|...||:..  |.:       :..| |:.:||.....|.|.:..::|           :.:.|
Mouse   492 LRADFQRHRRSGGCTEPSSGDGARMAPHEVGMAPNEVEMAVAAVATVEP-----------EELEA 545

  Fly   812 QAAAQKAALANIQQQQAAAQARNNLQAAALAAQNAAKMRQRAPQPPKQNIVRNPAPVRGGNAMNA 876
            ..|..:...|.:......|:||.:.|.....|..|.     .|...|     :|.|.|....|..
Mouse   546 APAETEEPEAGVADGDTEAEARQDEQVVVAPAAEAT-----VPDSKK-----DPEPDRRFREMGN 600

  Fly   877 GLSL---PNS------YQLAAGQLVQASKKPMAGQPSISI--------------TPLPRQS---- 914
            ||:.   |:|      :.:.....:.....|:.|.|..|.              :||..|.
Mouse   601 GLAEGEGPSSHPFGFHFPMHPKSWLHPDGFPILGFPEFSERLQADGRHLPGPLGSPLSLQGMGLA 665

  Fly   915 -----SVGAGAGAS--------------SSKAPQAAAGMKPGQSPSGNNKAQFVICEICDGYIKD 960
                 |||.|||..              |..||.|.|   ..:||        .||..|......
Mouse   666 CDPFRSVGPGAGVDGGLRAFPPAVRSLLSEPAPAALA---EEESP--------WICSDCGKTFGR 719

  Fly   961 LEQLRNHMQW-------------------MHKVKIHPKMIYNRPPLNCQKCQFRFFTDQGLERHL 1006
            ...|..|.::                   .|..: |.:......|..|.:|..||.....|..|:
Mouse   720 RAALAKHQRYHAGERPHRCADCGKSFVYGSHLAR-HRRTHTGERPFPCPECGARFARGSHLAAHV 783

  Fly  1007 LGSHGLVTSSMQEAANKGKDAGRCPVCGRMYQWKLLNHVSRDHHMTLK-PAHLS---YKCTVCTA 1067
            .|             :.|:....|.|||..:        ||..|:|.. .||..   |.|..|..
Mouse   784 RG-------------HTGEKPFVCGVCGAGF--------SRRAHLTAHGRAHTGERPYACAECGR 827

  Fly  1068 TFGMYKQFETHVYTAHSTVARKAMDSKKNSAQSSGSGSG 1106
            .||.......|.: ||:       :.|.:.....|.|.|
Mouse   828 RFGQSAALTRHQW-AHA-------EEKPHRCPDCGKGFG 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEP-1	NP_001137875.1	BSP_II	<121..>226	CDD:283165	5/19 (26%)
		C2H2 Zn finger	951..977	CDD:275371	5/44 (11%)
		C2H2 Zn finger	989..1010	CDD:275371	7/20 (35%)
Zfp316	NP_059495.3	KRAB	155..215	CDD:214630	17/101 (17%)
		COG5048	<339..499	CDD:227381	37/174 (21%)
		C2H2 Zn finger	343..363	CDD:275368	4/19 (21%)
		C2H2 Zn finger	371..391	CDD:275368	5/25 (20%)
		zf-H2C2_2	383..408	CDD:372612	7/30 (23%)
		C2H2 Zn finger	399..419	CDD:275368	1/19 (5%)
		C2H2 Zn finger	427..447	CDD:275368	5/20 (25%)
		C2H2 Zn finger	455..475	CDD:275368	4/20 (20%)
		C2H2 Zn finger	483..501	CDD:275368	7/17 (41%)
		PRK13108	<507..584	CDD:237284	16/92 (17%)
		C2H2 Zn finger	710..730	CDD:275368	4/19 (21%)
		zf-C2H2	710..730	CDD:333835	4/19 (21%)
		zf-H2C2_2	722..747	CDD:372612	2/24 (8%)
		C2H2 Zn finger	738..758	CDD:275368	2/20 (10%)
		COG5048	<763..950	CDD:227381	31/125 (25%)
		C2H2 Zn finger	766..786	CDD:275368	7/32 (22%)
		C2H2 Zn finger	794..814	CDD:275368	8/27 (30%)
		C2H2 Zn finger	822..842	CDD:275368	5/20 (25%)
		C2H2 Zn finger	850..870	CDD:275368	3/9 (33%)
		C2H2 Zn finger	878..898	CDD:275368
		C2H2 Zn finger	906..926	CDD:275368
		C2H2 Zn finger	934..954	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100