DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MEP-1 and CG11456

DIOPT Version :9

Sequence 1:	NP_001137875.1	Gene:	MEP-1 / 38327	FlyBaseID:	FBgn0035357	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_001262130.1	Gene:	CG11456 / 40309	FlyBaseID:	FBgn0037031	Length:	445	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	104/547 - (19%)
Similarity:	156/547 - (28%)	Gaps:	212/547 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   643 KMRKAQVQNSKEFEMAINALSGNLQ--ASKTKNAPFK-FR-------MKRCEF---CNFKSESAM 694
            |.:.|...||::.:..:.. |.|.:  ||:.:..||| ||       ::.|.|   |.||.:.|.
  Fly    52 KEQTAAGSNSQDKQTVVER-SENSEPPASELQPMPFKDFRLVLRANMLEPCSFGKECPFKFQDAT 115

  Fly   695 AMANHYETPHMNGVLYKCNFCTFEIRNATEIVYHMEAVHNIKARLIKPLPYHQCP--NCGFEDNG 757
            .|..|... |..| .:.|..|..|:.|......|:...|.:...|:      .||  .|.::...
  Fly   116 KMELHCSC-HKGG-SFSCCECGMELPNWRRCSAHLWKAHQVDVDLL------VCPVFECNYKSPI 172

  Fly   758 KAKLARHQPVCAKKFRPELNLAPPNDWEAPAKIPRIKPRHGLVGTATAYQAMAAQAAAQKAALAN 822
            .|.:.||..| .||:||                                               .
  Fly   173 SALVWRHMQV-HKKWRP-----------------------------------------------R 189

  Fly   823 IQQQQAAAQARNNL--QAAALAAQNAAKMRQRAPQPPKQNIVRNPAPVRGGNAMNAGLSLPNSYQ 885
            :.:..||.|.|..|  |:|.:|||.||       .||.                    |..|.|
  Fly   190 VLRSLAAVQRRRKLKEQSAEMAAQPAA-------LPPS--------------------SKKNKY- 226

  Fly   886 LAAGQLVQASKKPMAGQPSISITPLPRQSSVGAGAGASSSKAPQAAAGMKPGQSPSGNNKAQFVI 950
                   .|.|                                                     .
  Fly   227 -------YAEK-----------------------------------------------------T 231

  Fly   951 CEICDGYIKDLEQLRNHMQWMH-KVK------------------IHPKMIYNRPPLNCQKCQFRF 996
            ||||:....:.:.|..|::.:| |:|                  ||.:......||.|.:|:|..
  Fly   232 CEICNRKFVNGKTLSKHVKTVHNKIKPFICNVCGKKTARKASLIIHMRQHTGEKPLQCGECKFST 296

  Fly   997 FTDQGLERHLLGSHGLVTSSMQEAANKGKDAGRCPVCGRMYQWKLLNHVSRDHHMTLKPAHLSYK 1061
            .....|.:|          ..:..:...:.:.:|..|.  |.....|.:.|  ||.|..|. :|:
  Fly   297 RDPSVLHKH----------RQRHDSQDTRSSLKCSQCD--YFCIQANALKR--HMRLNHAE-AYR 346

  Fly  1062 ---CTVCTATFGMYKQFETHVYTAHSTVARKAMDSKKNSAQSSGSGSGAGMSRSSLGAANDSLLK 1123
               |.:|:.|....::...|.......:.....||....|.........|.....:.|   ....
  Fly   347 DLCCDICSFTSINVERLRAHKQDHRQGLITNCEDSMDARAAGFKYPRKVGDKNGEISA---DCFM 408

  Fly  1124 PLKINDEI----------TIIPQPASK 1140
            ||:..|.:          ..||.|.|:
  Fly   409 PLESVDSLPHEPALDTGGVTIPAPPSE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEP-1	NP_001137875.1	BSP_II	<121..>226	CDD:283165
		C2H2 Zn finger	951..977	CDD:275371	9/44 (20%)
		C2H2 Zn finger	989..1010	CDD:275371	5/20 (25%)
CG11456	NP_001262130.1	C2H2 Zn finger	232..253	CDD:275368	6/20 (30%)
		C2H2 Zn finger	261..281	CDD:275368	2/19 (11%)
		C2H2 Zn finger	289..309	CDD:275368	5/29 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100