DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MEP-1 and row

DIOPT Version :9

Sequence 1:	NP_001137875.1	Gene:	MEP-1 / 38327	FlyBaseID:	FBgn0035357	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_001260992.1	Gene:	row / 36685	FlyBaseID:	FBgn0033998	Length:	1301	Species:	Drosophila melanogaster

Alignment Length:	1087	Identity:	192/1087 - (17%)
Similarity:	339/1087 - (31%)	Gaps:	347/1087 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 EESVASEGVVEEEPPAK---------QENGF-GASPNQ------KE--NGQASIAEARAAIAPSD 238
            |.|:..|..|||..||:         :.|.. ||..|.      ||  |||...|.:      ..
  Fly     8 EISLDMEFWVEELSPAQLAYYEKITNEHNAVKGALKNAVSANEGKELFNGQVFQAYS------FK 66

  Fly   239 GGVVNLDEDSDEEMEDITEHKEPAKPTEKAAKPASSSGGESSDDAVLIASDSDTESAAPPPPVKK 303
            |.|:       :|:::.|..|:|.|||:..:.||:.|||              |......||.:
  Fly    67 GKVL-------QELKEATLPKKPPKPTDSPSTPAAQSGG--------------TGRGRGRPPRQ- 109

  Fly   304 LPPVVKAIPPPPVQDDEDDDDDDDCVVIEDDTP----LSISPSGKRKSDLDDLQLQQPSHKRQRS 364
                     |..:...|..|:.|      ||.|    |::|...|..:..:......|...::.:
  Fly   110 ---------PSNIAYLESSDEGD------DDMPLAKRLALSAGKKAVAVANASSSFTPKSSKKAA 159

  Fly   365 STPSGMGQLTIKDARSLMPLDGSPSSVSGPRDSIYPVTITNAVTGAATN---------------- 413
            |..||.....:..:...:..:..|...|.|::  |.....|:|.|....
  Fly   160 SAASGGSSSPVPKSSGKLFKESKPDIESPPKN--YRPAEVNSVGGLVVGSTDESKDSKDGKDGKD 222

  Fly   414 ---LGVVPPKLVPMA------GGMSASPVQLNPP---TLSLT-----------GL----PSMTNN 451
               .|...|.||.:|      ..|:|:..:|:..   .|.||           ||    ....|:
  Fly   223 NKMQGKTYPSLVVLAKPFLKIKDMAATRSKLDSKVKLVLMLTPNKFCEWLLQEGLLRAQQHCINH 287

  Fly   452 AN--LLPGLTDDM-------------------FV-----------LEAPSFIVPYIYEKPPRENI 484
            .|  |..|:..|:                   ||           ...|:|::..||....:.:|
  Fly   288 RNNELKLGIYSDVTKFPYTGGYVWISECCPYRFVSVFNNSIFEGAQHPPTFLLKLIYHWACQTSI 352

  Fly   485 CEVVKAIETKYALSAEDLAEADKGDEFDMMTEQNKEDKPADQADESG-------------KKKKK 536
            ..||:.::                               .|.....|             .:|.|
  Fly   353 QNVVQWVK-------------------------------VDSVYIKGIYTWLRAICTLAVHQKCK 386

  Fly   537 KRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLIKEANDDLSALKVAIKPAAALATAGGVSVNNP 601
            |.|....:.|...........|.|:..|:.:||......:.|....|::|..
  Fly   387 KLGGPGKFVEVGVISLGTTSQDGSQRQVKVEVLGVYDYAEKSIRLRAVEPIT------------- 438

  Fly   602 GGNKPGQENY---FES---PLGKFF-------MDIGVGLVQEYVQSDLLRLQKRKMRKAQVQNSK 653
                .|..||   |::   ||.::.       :|:.|..:..:                    |.
  Fly   439 ----DGDRNYKKRFQAILEPLSRWVHKDSTICIDLTVDKITLF--------------------SM 479

  Fly   654 EFEMAINALSGNLQASKTKNAPFKF--RMKRCEFCNFKSESAMAMANHYETPHMNGVLYKCNFCT 716
            .|:..:.|.:.:..|....:|..::  |:....|.|..|..:..|...:    ::.::::.:|.|
  Fly   480 GFKNIVQAAATDNTAKHNNSAVMEYLRRIVPRMFQNTLSLLSRQMIQQF----LDELVWRESFGT 540

  Fly   717 FEIRNATEIVYHMEAVHNIKARLIKPLPYHQCPNCGFED------NGKAKLARHQPVCAKKFRPE 775
            :.::....|:.|:.....:..........:|.....|:|      |.|...|...|   |:.:..
  Fly   541 YALQAFNNIIIHIAEQTRVTTNETITQRLYQVATNPFKDWSILPANYKETPANAAP---KRLKKP 602

  Fly   776 LNLAPPNDWEAPAKIP--------------RIKPRHGLVGTATAYQAMAAQAAAQKAALANIQQQ 826
            :|.|   |:....|||              |.:|.:.| ||......:.........:....:..
  Fly   603 INDA---DYVVSNKIPKKEKDRDIASSGVKRGRPPNAL-GTPPPQLPIKKGPGRPPGSTNQTKGD 663

  Fly   827 QAAAQARNNLQAAALAAQNAAKMRQRAPQPPKQNIVRNPAPVRGGNAMNAGL------------- 878
            :|...:..:|..:.:|.....|.:::..:.| ..|.:....:||...:..|:
  Fly   664 RATTSSSKSLSKSLIAKGLGKKPKEKDEKIP-MVIKKEEDDLRGLEELYYGISDGTDEYHEIFPY 727

  Fly   879 SLPNSYQLAAGQLVQA----------SKKPMAGQPSISITPLPRQ--------------SSVGAG 919
            |.|.:......:.|:.          |.:.:.......|:|..:|              .||.|
  Fly   728 STPRTVHNELAKTVECPICLNGDSFDSNEKLQTHLVSHISPEGKQHQFQCLFCLEKHPTESVLA- 791

  Fly   920 AGASSSKAPQAAAGMKPGQSPSGNNKAQFVICEICDGYIKDLEQLRNHMQWMHKVKIHPKMIYNR 984
                  |..|.   |.|.::.:..:.:.:  |.||......|..|..|:|     |:|..:   .
  Fly   792 ------KHNQI---MHPTETKTEGSPSYY--CLICQQRHNSLHLLTAHLQ-----KVHSTL---E 837

  Fly   985 PPLNCQKCQFRFFTDQGLERHLLGSHGLVTSSMQEAANKGKDAGRCPVCGRMYQWK---LLNHVS 1046
            .|..|..|.:|..:.:.|.||....|            |.::..:||.|..::.:.   ::|.:.
  Fly   838 LPYWCHSCGYRSSSHRDLVRHFYDDH------------KHQNFLQCPYCLDIFYFSKLGVVNQLR 890

  Fly  1047 RDHHMTLKPAHL-----SYKCTVCTATFGMYKQFETHVYTAHSTVAR 1088
            .:|:......|:     |.:|..|:.:|......:.|....|.::.:
  Fly   891 IEHYFMHLDEHINKRDPSLRCQKCSLSFLEKGDLKQHAVQHHVSMTK 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEP-1	NP_001137875.1	BSP_II	<121..>226	CDD:283165	17/51 (33%)
		C2H2 Zn finger	951..977	CDD:275371	8/25 (32%)
		C2H2 Zn finger	989..1010	CDD:275371	6/20 (30%)
row	NP_001260992.1	C2H2 Zn finger	777..798	CDD:275368	5/30 (17%)
		C2H2 Zn finger	812..833	CDD:275368	8/25 (32%)
		C2H2 Zn finger	842..858	CDD:275368	4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100