DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MEP-1 and Zfp532

DIOPT Version :9

Sequence 1:	NP_001137875.1	Gene:	MEP-1 / 38327	FlyBaseID:	FBgn0035357	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_001347980.1	Gene:	Zfp532 / 328977	MGIID:	3036282	Length:	1304	Species:	Mus musculus

Alignment Length:	1300	Identity:	236/1300 - (18%)
Similarity:	388/1300 - (29%)	Gaps:	465/1300 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTEVDVVLPEGVAEPTTKLASASSSPKQSKPSADDVEQQVTTVEDDEEQVVEEQQ--EEDVHLPE 63
            ||..|:..|:     ...|.:|...|....|.|     .:.:..||.|..:::..  ::|.|.|
Mouse     1 MTMGDMKTPD-----FDDLLAAFDIPDMVDPKA-----AIESGHDDHESHIKQNAHVDDDSHTP- 54

  Fly    64 APSNEKLELLSAGGKDISKEDVAQASPQAPVADEIMEVDGTEDVEE---NEVENDDEDSQITSSS 125
                             |..||.    .:.:...:..:|.:|.||:   |...|...:..:|:||
Mouse    55 -----------------SSSDVG----VSVIVKNVRNIDSSEGVEKDGHNPTGNGLHNGFLTASS 98

  Fly   126 SKEPKLDEEDEEATTNGDGDHEPEDEDDAQKIGSTAENSCEAEDPLGAVTVPDDELASGKKAHLD 190
                 ||                       ..|.....|.:.:.|...||:.|...:...... .
Mouse    99 -----LD-----------------------SYGKDGAKSLKGDTPASEVTLKDPAFSQFSPIS-S 134

  Fly   191 GEESVASEGVVEEEPPAKQE--NGF------GASPNQKEN------GQASIAEARAAIAPSDGGV 241
            .||....|.:..::||.|:|  .||      |::|.|..:      |:.|.....:....:|...
Mouse   135 AEEFEDDEKIEVDDPPDKEEARAGFRSNVLTGSAPQQDFDKLKALGGENSSKTGVSTSGHTDKNK 199

  Fly   242 VNLDEDSDEEMEDITEHKEPAKPTEKA--------------AKPASSSGGESSDDAVLIASDSDT 292
            |..:.:|:.....:.|..:..|..:|.              .||:|    |.||..:..|:.|.|
Mouse   200 VKREAESNSITLSVYEPFKVRKAEDKLKENSEKMLESRVLDGKPSS----EKSDSGIAAAASSKT 260

  Fly   293 ESAAPPPPVKKLPPVVKAIPPPPVQDDEDDDDDDDCVVIEDDTPL----SISPSGKRKSDLDDLQ 353
            :      |..||...:.||.....:....|...:......:.:||    :.||....||
Mouse   261 K------PSSKLSSCIAAIAALSAKKAASDSCKEPVANSREASPLPKEVNDSPKAADKS------ 313

  Fly   354 LQQPSHKRQRSSTPSGMGQLTIKDARSLMPLD------------GSPSSVSGPRDSIYPVTITNA 406
                         |.....:......||.|.|            |||||..|...:|..|.|...
Mouse   314 -------------PESQNLIDGTKKASLKPSDSPRSVSSENSSKGSPSSPVGSTPAIPKVRIKTI 365

  Fly   407 VTGAA----TNLGVVPPKLVPMAGGMSASPVQLNPPTLSLTGLPSMTNNANLLPGLTDDMFVLEA 467
            .|.:.    |...|:|.  |.:..|...|. |......|:|.|.|.:.:|.:|
Mouse   366 KTSSGEIKRTVTRVLPE--VDLDSGKKPSE-QAASVMASVTSLLSSSASATVL------------ 415

  Fly   468 PSFIVPYIYEKPPRENICEVVKAIETKYALSAEDLAEADKGDEFDMMTEQNKEDKPADQA----- 527
                     ..|||       ..::|....||...||         :|.:....||...|
Mouse   416 ---------SSPPR-------APLQTAMVTSAVSSAE---------LTPKQVTIKPVATAFLPVS 455

  Fly   528 --DESGKK---------KKKKRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLIKEANDDLSAL- 580
              ..:|.:         ...|.....:.|.||                .:..:||.||    |:
Mouse   456 AVKTAGSQVINLKLANNTTVKATVISAASVQS----------------ASSAIIKAAN----AIQ 500

  Fly   581 -KVAIKPAAALATA----GGVSVNN----PGG-----------NKPGQENYFESPLGKFFMDIGV 625
             :..:.||::||.|    ..|.:.|    |.|           .||.|:
Mouse   501 QQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQ---------------- 549

  Fly   626 GLVQEYVQSDLLRLQKRKMRKAQVQNS------KEFEMAINAL------SGNLQASKTKNAPFKF 678
              :::.:.:.......:|:.:.||.:|      :.|...::::      :.||............
Mouse   550 --IKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYTPNLSPPANAGITLPM 612

  Fly   679 RMKRCEFCNFKSESAMAMANHYETPHMNGVLYKCNFCTFEI--RNATEIVYH----------MEA 731
            |..:|..|........:::.||:...:. :...||.||..:  .|...::.|          |:.
Mouse   613 RGYKCLECGDAFALEKSLSQHYDRRSVR-IEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQC 676

  Fly   732 VHNIKARLIKPLPYHQCPNCGFEDNGKAKLARHQPVCAKKFRPELNLAPPNDWEAPA-------- 788
            .|.|    :||:|..|.                             :.||:...|.:
Mouse   677 SHLI----LKPVPADQM-----------------------------IVPPSSNTAASTLQSSVGA 708

  Fly   789 ---KIPRIKPRHGLVGTATAYQAMAAQAAAQKAALANIQQQQAAAQARNNLQAAALAAQNAAKMR 850
               .:|:::|  |:.|..                        .:|.|...:..|....::.:|:.
Mouse   709 ATHTVPKVQP--GIAGAV------------------------ISAPASTPMSPAMPLDEDPSKLC 747

  Fly   851 QRAPQPPKQNIVRNPAPVRGGNAMNAGLSLPNSYQLAAGQLVQASKKPMAGQPSISITP--LPRQ 913
            :.:.:..:.|.|....|           ||...:|.||         ..:||.:.::..  ||.|
Mouse   748 RHSLKCLECNEVFQDEP-----------SLATHFQHAA---------DTSGQKTCTVCQMLLPNQ 792

  Fly   914 SSVGAGAGASSSKAPQAAAGMKPGQSPSGNNKAQFVICEICDGYIKDLEQLRNHM--QWMHKVKI 976
            .|..:.......|:|..                    |..|....:.: ..:||:  ..:|..:
Mouse   793 CSYASHQRIHQHKSPYT--------------------CPECGAICRSV-HFQNHITKNCLHYTR- 835

  Fly   977 HPKMIYNRPPLNCQKCQFRFFTDQGLERHLLGSHGLVTSSMQEAANKGKDAGRCPVCGRMYQWKL 1041
                   |....|..|...:.....|:.|:.|||..|..             :||:|...::...
Mouse   836 -------RVGFRCVHCNVVYSDVAALKSHIQGSHCEVFY-------------KCPICPMAFKSAP 880

  Fly  1042 LNHVSRDHHMTLKPA------HLSYKCTVCTATFG----MYKQFETHVYTAHSTV---------- 1086
            ..|   .|..|..|.      .:.|||::|...|.    :|:.|:.|......:|
Mouse   881 STH---SHAYTQHPGVKIGEPKIIYKCSMCDTVFTLQTLLYRHFDQHTDNQKVSVFKCPDCSLLY 942

  Fly  1087 ARK--AMDSKKNSAQSSGSGSGAGMSRSSLGAANDSLLKPLKINDEITIIPQPASKPRITNMESH 1149
            |:|  .||..|         |..|..:|..|..|..:..||.:            ||...|..:|
Mouse   943 AQKQLMMDHIK---------SMHGTLKSIEGPPNLGINLPLSV------------KPATQNSANH 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEP-1	NP_001137875.1	BSP_II	<121..>226	CDD:283165	24/118 (20%)
		C2H2 Zn finger	951..977	CDD:275371	5/27 (19%)
		C2H2 Zn finger	989..1010	CDD:275371	5/20 (25%)
Zfp532	NP_001347980.1	BASP1	150..360	CDD:330577	49/238 (21%)
		C2H2 Zn finger	753..772	CDD:275368	5/29 (17%)
		C2H2 Zn finger	782..802	CDD:275368	4/19 (21%)
		C2H2 Zn finger	810..832	CDD:275368	4/22 (18%)
		C2H2 Zn finger	841..858	CDD:275368	3/16 (19%)
		C2H2 Zn finger	869..890	CDD:275368	6/23 (26%)
		C2H2 Zn finger	904..924	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1024..1044	CDD:275368
		C2H2 Zn finger	1054..1075	CDD:275368
		C2H2 Zn finger	1084..1104	CDD:275368
		C2H2 Zn finger	1179..1199	CDD:275368
		zf-C2H2_11	1202..1230	CDD:318763
		C2H2 Zn finger	1208..1229	CDD:275368
		C2H2 Zn finger	1269..1289	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I5013
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050