DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MEP-1 and Zfp451

DIOPT Version :9

Sequence 1:	NP_001137875.1	Gene:	MEP-1 / 38327	FlyBaseID:	FBgn0035357	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_001028877.2	Gene:	Zfp451 / 316312	RGDID:	1305865	Length:	1052	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	119/728 - (16%)
Similarity:	229/728 - (31%)	Gaps:	201/728 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   486 EVVKAIETKYALSAEDLAEADKGD-------------EFDMMTEQNKEDKPADQADESGKKKKKK 537
            |:::::.......:|..|:.::.|             |:..:...:.|:.....:||:.|.|
  Rat     7 EIIESVPPAGPEPSESTADENEDDIQFVSEGPLRPVLEYIDLVSSDDEEPSTSHSDENFKHK--- 68

  Fly   538 RGDDESWSEQSDD------------DDDEDDDDDSESGVRTKVLIKEAN--DDLSALKVAIKPAA 588
                :....|.|.            :.::...::.....|.|:..:.|:  .:|..::...:..|
  Rat    69 ----DYIDHQKDKVALTLARLARHVEVEKQQKEEKNRAFREKIDFQHAHGLQELEFIQGHSETEA 129

  Fly   589 A-------LATAG-GVSVNNPGGNKPGQENYFESPLGKFFMDIGVGLVQEYVQSDLLRLQKRKMR 645
            |       |..:| ..|..|.|..|..|..      |:                  :|...:.:.
  Rat   130 ARQCVDQWLKMSGLRTSAINSGSKKSFQSG------GR------------------MRRSDKSIL 170

  Fly   646 KAQVQNSKEFEMAINALSGNLQ--------ASKTKNAPFKFRMKRCEFC------------NFKS 690
            ...:..:|||:.. :.|.|:|:        .:.|.:.|.. .:..|..|            :..|
  Rat   171 CPIMHCNKEFDNG-HLLLGHLKRFDHSPCDPTITLHGPLA-NVFACAVCYEHFVTQQQYKDHLLS 233

  Fly   691 ESAMAMANHYETPHMNGVLYKCNFCTFEIRNATEIVYHMEAVHNIKARLIKPLPYHQCPNCGFED 755
            ::|.|..:..:.|......:.|..|........|.:.||.|.::          :||....| :|
  Rat   234 KAAAADGHSNDLPPQIIQCFACPHCFLLFSTKDECLKHMSAKNH----------FHQSLKLG-DD 287

  Fly   756 NGKAKLARHQPVCAKKFRPELNLAPPNDWEAPAKIPRIKPRHGLVGTATAYQAMAA--QAAAQKA 818
            .|.|:     ||....|..:|.::...|      :|.:........|..::..::|  :...:.|
  Rat   288 KGTAR-----PVSFPSFAKKLLVSLCKD------VPFLVKCVACHQTLRSHMELSAHFRVRCRNA 341

  Fly   819 ALANIQQQQAAAQARNNLQAAALAAQNAAKMRQRAPQPPKQNIVRNPAPVRGGNAMNAGLSLPNS 883
            ....|.::.....|:..|.....:..|...|.:.:.|..|     ||     |:.|:...|:..|
  Rat   342 GPVAIAEKSITQVAKEFLVRGYCSDCNQVFMDEASTQSHK-----NP-----GHKMSFANSVEES 396

  Fly   884 YQLAAGQLVQASKKP----MAGQPSIS----------------ITPLPRQSSVGAGAGASSSKAP 928
            ..|.. .:.:.|:.|    :..||.||                :.| .::.::|..:...:::..
  Rat   397 VLLYC-HISEGSRPPCDLHLFNQPKISSLKRILSSKESSAEDCVIP-TKKVNLGVDSQGGTARVQ 459

  Fly   929 QAAAGMK------PGQSPSGNNKAQFVI--------CEICDGYIKDLEQLRNHMQWMHKVKIHPK 979
            :..:.:.      ..:.||.:...:.|.        |.:|....:|...:|.||.     :.|..
  Rat   460 RQRSTVTAWFCECSRRFPSEDAVEKHVFSANTMCYKCVVCGKVCEDSGVMRLHMS-----RFHGG 519

  Fly   980 MIYNRPPLNCQKCQFRFFTDQGLERHLLGSH-------------GLVTSSMQE------------ 1019
            ...|.....|:.|:........:..|:...|             ..|.||..|
  Rat   520 AHLNNFLFWCRMCKKELIRKDAIMAHVTEFHSGHRYFYEMDEVEAAVPSSSTENHLNADKPPSPI 584

  Fly  1020 -------AANKGKDAGRCPVCGRMYQWKLLNHVSRDHHMTLKPAHL--SYKCTVCTATFGMYKQF 1075
                   |::..:...:|.:|..|:.    :|.....|.....:|.  .|.|..|..||...:..
  Rat   585 AVVDHSPASSPPRGRWQCRICEDMFD----SHECVQQHCASLTSHRFHRYSCAHCRKTFHKVETL 645

  Fly  1076 ETHVYTAHSTVAR 1088
            ..|....||...|
  Rat   646 CRHCQDEHSGEVR 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEP-1	NP_001137875.1	BSP_II	<121..>226	CDD:283165
		C2H2 Zn finger	951..977	CDD:275371	6/25 (24%)
		C2H2 Zn finger	989..1010	CDD:275371	3/20 (15%)
Zfp451	NP_001028877.2	zf-Di19	630..685	CDD:398954	9/29 (31%)
Zfp451	NP_001028877.2	PIN_11	876..993	CDD:408272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100