DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MEP-1 and Zfp438

DIOPT Version :9

Sequence 1:	NP_001137875.1	Gene:	MEP-1 / 38327	FlyBaseID:	FBgn0035357	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_001347376.1	Gene:	Zfp438 / 240186	MGIID:	2444919	Length:	798	Species:	Mus musculus

Alignment Length:	974	Identity:	160/974 - (16%)
Similarity:	264/974 - (27%)	Gaps:	417/974 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 AAIAPSDGGVVNLDE---------DSDEEMEDITEHKEPAKPTEKAAK-PASSS----------- 275
            :::.|.|.|..|:..         .|..:...|.....|...|.:... |:|.|
Mouse     5 SSVPPKDQGESNIRSGTTQSGKTLQSKSQFRTIAPKVVPKVLTSRVLPCPSSISDQGSLTLMPKP 69

  Fly   276 -GGESSDDAVL-IASDSDTESAAPPPPVKKLPPVVK---------AIPPPPVQDDEDDDDDDDCV 329
             |..:.:.|:: :|....|.|....|.|....||.|         .:|.|..|
Mouse    70 LGMPTQNYALMQVAGQEGTFSLVAFPNVASAQPVQKPRMSTHENLKLPIPRYQ------------ 122

  Fly   330 VIEDDTPLSISPSGKRKSDLDDLQLQQPSHKRQRSSTPSGMGQLTIKDARSLMPLDGSPSSVSGP 394
                  ||| |...::|.||        |..:..||.|.|..|        |..|..||.:...|
Mouse   123 ------PLS-SQGLRKKQDL--------SSPKSGSSDPPGPSQ--------LCHLTSSPQAYPDP 164

  Fly   395 RDSIYPVTITNAVTGAATNLGVVPPKLVPMAGGMSASPVQLNPPTLSLTGLPSMTNNANLLPGLT 459
            ...                     |.|......::.||..:|..||:     |.....:|.|.:|
Mouse   165 HHK---------------------PSLWKQMPTLNPSPTNINTATLT-----SGVGQGDLSPLVT 203

  Fly   460 DDMFVLEAPSFIVPYIYEKPPRENICEVVKAIETKYALSAEDLAEADKGD-EFDMMTEQNKEDKP 523
                                   |.|                      || |...|.....||..
Mouse   204 -----------------------NSC----------------------GDLELSAMPVYTTEDSS 223

  Fly   524 ADQA-----DESGKKKKKKRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLIKEANDDLSALKVA 583
            :.|:     .::|..:|                         |:.....:..:|..:.|::.:..
Mouse   224 SQQSLPASMQKAGCARK-------------------------EAPTTPAIASEELKEQLASAQTV 263

  Fly   584 IKPAAALATAGGVSVNNPGGNKPGQENYFESPLGKFFMDIGVGLVQEYVQSDLLRLQKRKMRKAQ 648
            :..|..|.:.                    .|.||..:            ..|.|::..::.|.:
Mouse   264 LSSAVQLLSV--------------------VPKGKLPI------------LPLPRVKTTEVGKVE 296

  Fly   649 VQNSKEFEMAINALSGNLQASKTKNAPFKFRMKRCEFCNFKSESAMAMANHYETPHMNGVLYKCN 713
                .:.:.|..:|||                     |....:..:::...::.
Mouse   297 ----SDADNAELSLSG---------------------CRANCDERLSITEGFDA----------- 325

  Fly   714 FCTFEIRNATEIVYHMEAVHNIKARLIKPLPYHQCPNCGFEDNGKAKLARHQPVCAKKFRPELNL 778
                    ||||...:.|:|..|                            |..|...|.|...|
Mouse   326 --------ATEIASKIAALHGSK----------------------------QSACESAFCPVTKL 354

  Fly   779 -----APPND--------WEAPAKIPRIKPRHGLVGTATAYQAMAAQAAAQKAALANIQQQQAAA 830
                 |.|:.        |:.|.:|                  :|.|...:|..:         .
Mouse   355 DLSHKAKPSSGIKRRGRKWKVPDEI------------------LALQGKRRKCII---------G 392

  Fly   831 QARNNLQAAALAAQNAAKMRQRAPQPPKQNIVRNPAPVRGGNAMNAGLSLPNSYQLAAGQLVQAS 895
            ...:.::.|..:.|.|...:.|......:||:  |.||                      ||.::
Mouse   393 MCGDGIERARNSPQEARDQKPRVASRKYRNIM--PKPV----------------------LVLSA 433

  Fly   896 KKPMAGQPSISITPLPRQSSVG------------AGAGASSSKAPQAAAGMKPGQSPSGNNKAQF 948
            ..|:|...:: ::..|  ||:|            .|:..|.|..|:.::.::.|.|   ..|..:
Mouse   434 LAPLASHTAV-LSQAP--SSLGQDVLNNALPSKCLGSKQSDSSTPKPSSVLRNGFS---GIKKPW 492

  Fly   949 VICEICDGYIKDLEQLRNHMQWMHKVKIHPKMIYNRPPLNCQKCQFRFFTDQGLERHLLGSHGLV 1013
            .:|.:|:          .|.|:.|.:..|.....||.|.:|..|:..:.....|..|:...||
Mouse   493 HMCPVCN----------YHFQFKHHLLDHMNTHTNRRPYSCGICRKTYVRPGSLSAHMKLHHG-- 545

  Fly  1014 TSSMQEAANKGKDAGRCPVCGRMYQWKLLNHVSRDHHMTLKPAHLSYKCTVCTATFGMYKQFETH 1078
                                              |:|    |..| ..|..|...||..:.:..|
Mouse   546 ----------------------------------DNH----PKKL-VCCEFCAKVFGHVRVYFGH 571

  Fly  1079 VYTAHSTVAR--------KAMDSKKNSAQSSG-SGSGAGMSRSSLGAANDSLLKPLKINDEITI 1133
            :...|..|..        :..|:.||..:..| .|....:.|.:..:..:..|  |...||:.:
Mouse   572 LKEVHRVVISTEPSPSELQPGDTPKNKNRDPGMQGPDNSLERETKSSLEEDFL--LNQADEVKL 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEP-1	NP_001137875.1	BSP_II	<121..>226	CDD:283165
		C2H2 Zn finger	951..977	CDD:275371	5/25 (20%)
		C2H2 Zn finger	989..1010	CDD:275371	4/20 (20%)
Zfp438	NP_001347376.1	C2H2 Zn finger	495..515	CDD:275368	6/29 (21%)
		zf-H2C2_2	507..532	CDD:372612	6/24 (25%)
		zf-C2H2	521..543	CDD:333835	4/21 (19%)
		C2H2 Zn finger	523..543	CDD:275368	4/19 (21%)
		C2H2 Zn finger	554..573	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100