Protein Alignment MEP-1 and mep-1

DIOPT Version :10

• Sequence 1: NP_647733.1
• Gene: MEP-1 / 38327
• FlyBaseID: FBgn0035357
• Length: 1152
• Species: Drosophila melanogaster
• Sequence 2: NP_502173.2
• Gene: mep-1 / 178074
• WormBaseID: WBGene00003218
• Length: 870
• Species: Caenorhabditis elegans
• Alignment Length: 1139
• Identity: 263/1139 - (23%)
• Similarity: 413/1139 - (36%)
• Gaps: 333/1139 - (29%)

  Fly     6 VVLPEGVAEPTTKLASAS---SSPKQSKPSADDVEQQVTTVEDDEEQVVEEQQEEDVHLPEAPSN 67
            |...|.|...||...|.|   :.|:.:..|:.|.|      .|..||:..||:|.   :.:|.:.
 Worm     2 VTADETVLATTTNTTSMSVEPTDPRSAGESSSDSE------PDTIEQLKAEQREV---MADAANG 57

  Fly    68 EKLELLSAGGKDISKEDVAQASPQAPVADEIMEVDGTEDVEENEVENDDEDSQITSSS---SKEP 129
            .::.    |.::..||:.|.|..      |::|:|.||:..:...:..||:....|:|   .:|.
 Worm    58 SEVN----GNQENGKEEAASADV------EVIEIDDTEESTDPSPDGSDENGDAASTSVPIEEEA 112

  Fly   130 KLDEEDEEATTNGDGDHEPEDEDDAQKIGSTAENSCEAEDPLGAVTVPDDELASGKKAHLDGEES 194
            :..:|.....|....:.|.:|:.|..:|         .|:|.|    ..::.|:|
 Worm   113 RKKDEGASEVTVASSEIEQDDDGDVMEI---------TEEPNG----KSEDTANG---------- 154

  Fly   195 VASEGVVEEEPPAKQENGFGASPNQKENGQASIAEARAAIAPSDGGV------VNLDEDSDEEME 253
            ..:|.|::||.|....||......:||...:|:     .:..:..||      :.||:|.|:|::
 Worm   155 TVTEEVLDEEEPEPSVNGTTEIATEKEPEDSSM-----PVEQNGKGVKRPVECIELDDDDDDEIQ 214

  Fly   254 DITEHKEPAKPTEKAAKPASSSGGESSDDAVLIASDSDTESAAPPPPVKKLPPVVKAIPPPPVQD 318
            :|:   .|| |.:||          ..||                         |||...|
 Worm   215 EIS---TPA-PAKKA----------KIDD-------------------------VKATSVP---- 236

  Fly   319 DEDDDDDDDCVVIEDDTPLSISPSGKRKSDLDDLQLQQPSHKRQRSSTPSGMGQLTIKDARSLMP 383
             |:|:::.                 .:|..||.|:......|.|.||             :|...
 Worm   237 -EEDNNEQ-----------------AQKRLLDKLEEYVKEQKDQPSS-------------KSRKV 270

  Fly   384 LDGSPSSVSGPRDSIYPVTITNAVTGAATNLGVVPPKLVPMAGGMSASPVQLNPPTLSLTGLPSM 448
            ||                          |.||.:            .:.||..|  ||:..|
 Worm   271 LD--------------------------TLLGAI------------NAQVQKEP--LSVRKL--- 292

  Fly   449 TNNANLLPGLTDDMFVLEAPSFIVPYIYEKPPRENICEVVKAIETKYALSAEDLAEADKGDEFDM 513
                     :.|.:.||       |.....||.: :|                          |:
 Worm   293 ---------ILDKVLVL-------PNTISFPPSQ-VC--------------------------DL 314

  Fly   514 MTEQNKEDKPADQADESGKKKKKKRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLIKEANDDLS 578
            :.|.:.|.......:....:::.|..|.|.                     |.:..:|:
 Worm   315 LIEHDPEMPLTKVINRMFGEERPKLSDSEK---------------------RERAQLKQ------ 352

  Fly   579 ALKVAIKPAAALATAGGVSVNNPGGNKPGQENYFESPLGKFFMDIGVGLVQEYVQSDLLRLQKRK 643
                                :||..|           :.|..:|||..||||....|::.   .|
 Worm   353 --------------------HNPVPN-----------MTKLLVDIGQDLVQEATYCDIVH---AK 383

  Fly   644 MRKAQVQNSKEFEMAINALSGNLQASKTKNAPFKFRMKRCEFCNFKSESAMAMANHYETPHMNGV 708
            ......:|.:.::.....|....:..|.||.|:|.:|.||:.|.|::||.:.|:.|.|..|..|.
 Worm   384 NLPEVPKNLETYKQVAAQLKPVWETLKRKNEPYKLKMHRCDVCGFQTESKLVMSTHKENLHFTGS 448

  Fly   709 LYKCNFCTFEIRNATEIVYHMEAVHNIKARLIKPLPYHQCPNCGFEDNGKAKLARHQPVCAKKFR 773
            .::|..|.....:...:..|....|.:.|:..:....:.|..|..:.|.|....:|...|.|.:.
 Worm   449 KFQCTMCKETDTSEQRMKDHYFETHLVIAKSEEKESKYPCAICEEDFNFKGVREQHYKQCKKDYI 513

  Fly   774 PELNLAPPND----------WEAPAKIPRIKPRHGLVGTATA-----YQAMAAQAAAQKAALANI 823
            ...|:..|..          ||.|...|.|..:........|     .|.:..|.|||.||.|.:
 Worm   514 RIRNIMMPKQDDHLYINRWLWERPQLDPSILQQQQQAALQQAQQKKQQQLLHQQQAAQAAAAAQL 578

  Fly   824 QQQQAAAQARNNLQAAALAAQNAAKMRQRAPQPPKQNIVRNPAPVRGGN--------AMNAGL-- 878
            .::|...|.:...||.....|.||:.||.|....:|:.....|....||        ||.|.|
 Worm   579 LRKQQLQQQQQQQQARLREQQQAAQFRQVAQLLQQQSAQAQRAQQNQGNVNHNTLIAAMQASLRR 643

  Fly   879 --SLPNSYQLAAGQLVQ---ASKKPMAGQPSISITPLPRQSSVGAGAGASSSKAPQAAAG---MK 935
              ...||  ||..||:|   |:.|...|...:       |::|.:....:|.|.|...:.   ..
 Worm   644 GGQQGNS--LAVSQLLQKQMAALKSQQGAQQL-------QAAVNSMRSQNSQKTPTHRSSKLVTT 699

  Fly   936 PGQSPSGNNKAQFVICEICDGYIKDLEQLRNHMQWMHKVKIHPKMIYNR---PPLNCQKCQFRFF 997
            |..:..|::.|...:|||||..:::.|:...|:|..||..: .|::.:.   .||.|.:|:.||:
 Worm   700 PSHATVGSSSAPTFVCEICDASVQEKEKYLQHLQTTHKQMV-GKVLQDMSQGAPLACSRCRDRFW 763

  Fly   998 TDQGLERHLLGSHGLVTSSMQEAANKGKDAGRCPVCGRMYQWKLLNHVSRDHHMTLKPAHLSYKC 1062
            |.:||||||:.||||||:.:...|.|.:|.|||..||:.|.:.:|.|:..||.:.|..|.:.|.|
 Worm   764 TYEGLERHLVMSHGLVTADLLLKAQKKEDGGRCKTCGKNYAFNMLQHLVADHQVKLCSAEIMYSC 828

  Fly  1063 TVCTATFGMYKQFETHVYTAH-------STVARK 1089
            .||......|:..|.|:.:.|       ||.|:|
 Worm   829 DVCAFKCSSYQTLEAHLTSNHPKGDKKTSTPAKK 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEP-1	NP_647733.1	C2H2 Zn finger	951..977	CDD:275371	10/25 (40%)
		C2H2 Zn finger	989..1010	CDD:275371	11/20 (55%)
mep-1	NP_502173.2	LGT	<7..144	CDD:469786	38/164 (23%)
		Agg_substance	72..>285	CDD:411439	70/358 (20%)