DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MEP-1 and pogza

DIOPT Version :9

Sequence 1:	NP_001137875.1	Gene:	MEP-1 / 38327	FlyBaseID:	FBgn0035357	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_001201839.1	Gene:	pogza / 100535215	ZFINID:	ZDB-GENE-040914-76	Length:	1277	Species:	Danio rerio

Alignment Length:	964	Identity:	174/964 - (18%)
Similarity:	300/964 - (31%)	Gaps:	305/964 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 DEDDAQKIGSTAENSCEAEDPLGAVTVPDDELASGKKAHLDG---EESVASEGVVEEEPPAKQEN 211
            |||:.:...|..|:..:.   |..|||....:.:......:|   :::.|:.|:..:..|.....
Zfish    14 DEDELEPCQSVTESRGQR---LNKVTVVPSVINAQISPQPNGASTDQTSAAFGLPNQAVPLASAP 75

  Fly   212 GFGASPNQKENGQASIAEARAAIAPSDG----GVVNLDED--SDEEMEDITEHKEPAKPTEKAAK 270
            .....||..:.|.|:......:..|:.|    |.:||...  :.:.:..:|..:.|.....:...
Zfish    76 AVTLLPNAVQTGGAAGQTIYFSAQPNSGQPLAGSMNLGTYFLNGQPVSFVTAGQTPQLIAPRMVT 140

  Fly   271 PAS---SSGGESS----DDAVLIASDSDTESAAPPPPVKKLPPVVKAIPPPPVQDDEDDDDDDDC 328
            |.|   ::.|:.|    ..|:.:.|.|:.:|..|..|                           .
Zfish   141 PGSAQQTAPGKVSTMQMPVALTLNSPSNLQSITPAAP---------------------------G 178

  Fly   329 VVIEDDTPLSISPSGKRKSDLDDLQ-LQQPSHKRQRSSTPSGMGQLTIKDARSLMPLDGSPSSVS 392
            |...:.||.:|.|:....|.:..:: ::.|       ..|...||:.              |||:
Zfish   179 VNARNVTPSNILPATAPGSIIKVIKFMKYP-------GAPGSAGQVM--------------SSVA 222

  Fly   393 GPRDSIYPVTITNAVTGAATNLGVVPPKLVPMAGGMSASPVQLNPPTLSLTGLPSMTNNANLLPG 457
            .|..   |::|.|::|                    ..:||.:.|..::.|.:|.|...|. .||
Zfish   223 QPSQ---PMSIQNSIT--------------------HQTPVSILPAGIAQTLMPQMQILAP-APG 263

  Fly   458 LTDDMFV-LEAPSFIVP---YIYEK--PPRENIC----EVVKAI-----ETKYALSAEDLAEADK 507
            ...:... ..:.|...|   .:|:|  |.|...|    |::|:|     .||..|.|.
Zfish   264 TASNALKRTSSSSTFCPRCKAVYQKSLPLRGYFCQCSQELIKSIWSLKSHTKNRLRAR------- 321

  Fly   508 GDEFDMMTEQNKEDKPADQADESGKKKKKKRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLIKE 572
                   :::...|.||..|  |.|..:|    |.:..|..:...:....|..|.| |..:|:::
Zfish   322 -------SKRPPRDTPASSA--SSKTSQK----DVTSCELPEGAPNPRSGDFDEQG-RMIMLVED 372

  Fly   573 ANDDLSALKVAIKPAAALATAGGVSVNNPGGNKPGQENYFESPLGKFFMDIGVGLVQEYVQSDLL 637
            ..                           .|..||:......|             .|::.....
Zfish   373 FF---------------------------YGQHPGRPADVRYP-------------WEHISMKCH 397

  Fly   638 RLQKRKMRKAQVQNSKEFEMAINALSGNLQAS-------KTKNAPFKFR------------MKRC 683
            ...|:.:...::.|..:..|..:..:|.:...       :..:.||..:            .|.|
Zfish   398 LCSKKLIGNIEMMNHMKHHMERDCRTGEVDCHTVCQHCYRNFSTPFGLQCHVEAVHIQAESSKVC 462

  Fly   684 EFCNFKSESAMAMANHYETPHMNGVL-YKCNFCTFEIRNATEIVYHMEAVHNIKARLIKPLPYHQ 747
            :.|....||.....||.:..|..|.: |.|..|.|......:::.|....|.....|:
Zfish   463 KICECLFESEPLFLNHMKHVHKPGEMPYVCKVCDFRSSFYKDVMNHFTEHHKDTCILL------- 520

  Fly   748 CPNC--------GFE---DNGKAKLARHQPVCAKKFRPELNLAPPNDWEAPAKIPR--IKPR--H 797
            |..|        ||:   ...:.|.||:...|..:|..|     .::|....:..|  :||:  .
Zfish   521 CVYCLKIFRSCGGFQLHYTRHQKKGARNCDKCRLQFCSE-----KDEWHHKQRFHRTYVKPKQLE 580

  Fly   798 GLV-GTATAYQAMAAQAAAQKAALANIQQQQAAAQARNNLQAAALAAQNAAKMRQRAPQPPKQNI 861
            ||| ||....:|.|                                  :....|.:..:||.:
Zfish   581 GLVPGTRIIIRAYA----------------------------------DNTDNRAQFGEPPVE-- 609

  Fly   862 VRNPAPVRGGNAMNAGLSLPNSYQLAAGQLVQASKKPMAGQPSISITPLPRQSSVGAGAGASSSK 926
               |.|       |. .|.|:..|....::|...|||:.....:.:
Zfish   610 ---PCP-------NT-TSTPDQSQNVHSKIVPVKKKPVESMVELMV------------------- 644

  Fly   927 APQAAAGMKPGQSP------------SGNNKAQFVICEICDGYIKDLEQLRNHMQWMHKVKIHPK 979
              :..:...|.:..            ..|:...:|.|.:|...........|||..:|..:...|
Zfish   645 --KFESNFNPKEKKYYCMECNHDIPYFSNHFPTYVSCSLCRYCTCCSRAYANHMISVHVPRKSTK 707

  Fly   980 ---MIYNRPP----LNCQKCQFRFFTDQGLERHLLG--SHGLVTSSMQEAANKG 1024
               .:|...|    |:|.||:|.......:.:||..  .|....|::||..::|
Zfish   708 KYITLYKPCPKKGRLSCTKCKFNTTIGDSMAKHLANFPKHQASRSTIQEGFSQG 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEP-1	NP_001137875.1	BSP_II	<121..>226	CDD:283165	16/78 (21%)
		C2H2 Zn finger	951..977	CDD:275371	6/25 (24%)
		C2H2 Zn finger	989..1010	CDD:275371	6/22 (27%)
pogza	NP_001201839.1	C2H2 Zn finger	432..453	CDD:275368	2/20 (10%)
		C2H2 Zn finger	462..483	CDD:275368	6/20 (30%)
		rve	1027..>1134	CDD:304425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000