DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxn and Pxdn

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	XP_006515268.1	Gene:	Pxdn / 69675	MGIID:	1916925	Length:	1503	Species:	Mus musculus

Alignment Length:	1557	Identity:	648/1557 - (41%)
Similarity:	885/1557 - (56%)	Gaps:	167/1557 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLGLLLLLA-------GGVQSVYCPAGCTCLERTVRCIRAKLSAVPKLPQDTQTLDLRFNHIEEL 67
            ||.|||..|       ...|...||:.|.|...||||:...|.|||.:...|..||||||.|.|:
Mouse    62 LLALLLCFAWWAMAVVASKQGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLRFNRIREI 126

  Fly    68 PANAFSGLAQLTTLFLNDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPRLEAIFLE 132
            ...||..|..|.||.||:|::..:.:||...|..|:::||:.|::..|....||.:|:||
Mouse   127 QPGAFRRLRSLNTLLLNNNQIKKIPNGAFEDLENLKYLYLHFNQIETLDPESFQHLPKLE----- 186

  Fly   133 NNDIWQLPAGLFDNLPRLNRLIMYNNKLTQLPVDGFNRLNNLKRLRLDGNAIDCNCGVYSLWRRW 197
                               ||.::||::|.|....|::|.::||||||.||:.|:|.:.     |
Mouse   187 -------------------RLFLHNNRITHLVPGTFSQLESMKRLRLDSNALHCDCEIL-----W 227

  Fly   198 HLDV-----QRQLVSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVELSC 257
            ..|:     |......:.||..|:.:|.:..:::......|.:|:....||||.|.:|..|..:|
Mouse   228 LADLLKTYAQSGNAQAAATCEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTC 292

  Fly   258 EVTGLPRPQITWMHNTQELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQPVR 322
            ...|.|:|:|.|:.|..||.::..::..:|..|:|:|::...:|.|:|||:|:|..|..::|.|.
Mouse   293 RAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQEADEGVYQCMAKNVAGEAKTQEVT 357

  Fly   323 LVVNGGNHPLDSPIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQPHDQIVALHGSGHVLLD 387
            |...|.                                 |:.|.|..||.:..|.:..|  |.|:
Mouse   358 LRYLGS---------------------------------PARPTFVIQPQNTEVLVGES--VTLE 387

  Fly   388 CAASGWPQPDIQWFVNGRQLLQSTPSLQLQANGSLILLQPNQLSAGTYRCEARNSLGSVQATARI 452
            |:|:|.|.|.|.|....|..|...|.:.:..:|.|.:....|..:|.|.|.|.||:.|:.|||.|
Mouse   388 CSATGHPLPQITWTRGDRTPLPIDPRVNITPSGGLYIQNVAQSDSGEYTCFASNSVDSIHATAFI 452

  Fly   453 ELKELPEILTAPQSQTIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQLENENTELVVG 517
            .::.||:....|||:.:..|:....:|.|.|:|.|.|.|...|..|..:...|.| :..|..:.|
Mouse   453 IVQALPQFTVTPQSRVVIEGQTVDFQCAAKGHPQPVIAWTKGGSQLSVDRRHLVL-SSGTLRISG 516

  Fly   518 AARQEHAGVYRCTAHNENGETSVEATIKVERSQSPPQLAIEPSNLVAITGTTIELPCQAD-QPED 581
            .|..:. |.|.|.|.|..|...|.|.:.|:...:|...:| ||::....||.::|||.:. :||.
Mouse   517 VALHDQ-GQYECQAVNIIGSQKVVAHLTVQPRVTPVFASI-PSDMTVEVGTNVQLPCSSQGEPEP 579

  Fly   582 GLQISWRHDGRLIDPNVQLAE--KYQISGAGSLFVKNVTIPDGGRYECQLKNQFGRASASALVTI 644
            .  |:|..||      ||:.|  |:.||..|.|.:.:|...|.|||||..:|..|.||.|.::::
Mouse   580 A--ITWNKDG------VQVTESGKFHISPEGFLTINDVGTADAGRYECVARNTIGYASVSMVLSV 636

  Fly   645 RNNVDLA-PGDRYVRIAFAEAAKEIDLAINNTLDMLFSNRSDKAPPNYGELLRVFRFP-----TG 703
             |..|:: .||.||..:..||...:|.|||:|...||.:|    |.:..:||.:||:|     .|
Mouse   637 -NVPDVSRNGDPYVATSIVEAIATVDRAINSTRTHLFDSR----PRSPNDLLALFRYPRDPYTVG 696

  Fly   704 EARQLARAAEIYERTLVNIRKHVQEGDNLTMKSEEYEFRDLLSREHLHLVAELSGCMEHREMPNC 768
            :    |||.||:||||..|::|||.|..:.:....|.:.||:|.::|.|:|.||||..||.:.||
Mouse   697 Q----ARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLSLIANLSGCTAHRRVNNC 757

  Fly   769 TDMCFHSRYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARL 833
            :|||||.:||:.||||||||||.||||||||.||...:|||||:.|.|......|:||..|..||
Mouse   758 SDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKAVYENGFNTPRGINSQRQYNGHVLPMPRL 822

  Fly   834 VSTSLVATKEITPDARITHMVMQWGQFLDHDLDHAIPSVSSESW-DGIDCKKSCEMAPPCYPIEV 897
            |||:|:.|:.||||.:.|||:||||||||||||..:.::|...: ||..|...|...|||:.:.:
Mouse   823 VSTTLIGTEVITPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSSVCSNDPPCFSVMI 887

  Fly   898 PPNDPRVRN-RRCIDVVRSSAICGSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTAFAQELR 961
            ||||||||: .||:..||||.:||||||||..:||..||||||||||||||.|||.:...|:.:|
Mouse   888 PPNDPRVRSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTDHEARSIR 952

  Fly   962 NLTSQEGLLRVGVHFPRQKDMLPFAAPQDGMDCRRNLDENTMSCFVSGDIRVNEQVGLLAMHTIW 1026
            :|.|..||||.|:.....|.:||||.... .:|.|:.:|:.:.||::||.|.|||:||.:|||:|
Mouse   953 DLASHRGLLRQGIVQRSGKPLLPFATGPP-TECMRDENESPIPCFLAGDHRANEQLGLTSMHTLW 1016

  Fly  1027 MREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEMMGEYQGYNPQ 1091
            .|||||||::|.::|.||||||:|.|.||||||::||||::.|||.|:||.||:|:|||:||:|.
Mouse  1017 FREHNRIAAELLKLNPHWDGDTVYHETRKIVGAEIQHITYRHWLPKILGEVGMKMLGEYRGYDPS 1081

  Fly  1092 LNPSIANEFATAALRFGHTIINPILHRLNETFQPIPQGHLLLHKAFFAPWRLAYEGGVDPLMRGF 1156
            :|..|.|.|||||.|||||:|||:|:||:|.|:||||||:.||||||:|:|:..|||:|||:||.
Mouse  1082 VNAGIFNAFATAAFRFGHTLINPLLYRLDENFEPIPQGHVPLHKAFFSPFRIVNEGGIDPLLRGL 1146

  Fly  1157 LAVPAKLKTPDQNLNTELTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYRKLCNLTVAQDFE 1221
            ..|..|::.|.|.|||||||:||..||.|||||||||||||||||:|.|:.||..|||:.|..||
Mouse  1147 FGVAGKMRIPSQLLNTELTERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAYTFE 1211

  Fly  1222 DLAGEISSAEIRQKMKELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLRDGDRLYY 1286
            ||..||.|..||:|::.|||...|:|::...::||.|.|.::||...|||..|||||||||||:|
Mouse  1212 DLKNEIKSPVIREKLQRLYGSTLNIDLFPALMVEDLVPGSRLGPTLMCLLSTQFRRLRDGDRLWY 1276

  Fly  1287 ENPGVFSPEQLTQIKQANFGRVLCDVGDNFDQVTENVFILAKHQGGYKKCEDIIGINLYLWQEC- 1350
            ||||||||.||||:||.:..|:|||..||..:|.::||.:|:...||..||||..::|.:||:|
Mouse  1277 ENPGVFSPAQLTQLKQTSLARILCDNSDNITRVQQDVFRVAEFPHGYSSCEDIPRVDLRVWQDCC 1341

  Fly  1351 ------GRCNSPPAIFD-------SYIPQTYTKRSNRQKRDL----GK--ENDEVATAESYDSPL 1396
                  |:.|:....|.       ||.....|||: |.::.|    ||  .|...||.|..:.|
Mouse  1342 EDCRTRGQFNAFSYHFRGRRSLEFSYEDDKPTKRA-RWRKALSVKHGKHLSNATSATHEHLEGP- 1404

  Fly  1397 ESLYDVNEERVSGLEELIGSFQKELKKLHKKLRKLEDSCNSADSEPVAQVVQLAAAPPQLVSKPK 1461
                     ..:.|:|.:...||.:..|.|::..||                         |:..
Mouse  1405 ---------ATNDLKEFVLEMQKIITDLRKQINSLE-------------------------SRLS 1435

  Fly  1462 RSHCVDDKGTTRLNNEVWSPDVCTKCNCFHGQVNCLRERCGEVSCPPGVDPLTPPEACCPHC 1523
            .:.||||.|.:...|..|..|.||.|.|.:||:.|..|.|...:||   .|:....||||.|
Mouse  1436 TTECVDDSGESHGGNTKWKKDPCTVCECKNGQITCFVEACQPAACP---QPVKVEGACCPVC 1494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064	35/109 (32%)
		leucine-rich repeat	54..77	CDD:275380	12/22 (55%)
		LRR_8	55..112	CDD:290566	24/56 (43%)
		leucine-rich repeat	78..101	CDD:275380	9/22 (41%)
		leucine-rich repeat	102..125	CDD:275380	7/22 (32%)
		LRR_8	124..184	CDD:290566	18/59 (31%)
		leucine-rich repeat	126..149	CDD:275380	2/22 (9%)
		LRR_4	148..185	CDD:289563	16/36 (44%)
		leucine-rich repeat	150..173	CDD:275380	8/22 (36%)
		Ig	240..325	CDD:299845	31/84 (37%)
		IG_like	242..325	CDD:214653	31/82 (38%)
		I-set	366..450	CDD:254352	28/83 (34%)
		Ig	384..451	CDD:143165	24/66 (36%)
		I-set	458..546	CDD:254352	27/87 (31%)
		Ig	472..536	CDD:299845	20/63 (32%)
		I-set	553..644	CDD:254352	34/93 (37%)
		Ig	570..643	CDD:299845	29/75 (39%)
		An_peroxidase	777..1317	CDD:281139	320/541 (59%)
		peroxidasin_like	898..1338	CDD:188658	260/440 (59%)
		VWC	1465..1523	CDD:278520	24/57 (42%)
Pxdn	XP_006515268.1	leucine-rich repeat	94..112	CDD:275380	8/17 (47%)
		leucine-rich repeat	113..127	CDD:275378	9/13 (69%)
		LRR_8	115..171	CDD:338972	24/55 (44%)
		LRR_8	160..219	CDD:338972	25/82 (30%)
		leucine-rich repeat	161..184	CDD:275378	7/22 (32%)
		leucine-rich repeat	185..208	CDD:275378	10/46 (22%)
		leucine-rich repeat	209..221	CDD:275378	8/11 (73%)
		TPKR_C2	217..268	CDD:387596	11/55 (20%)
		I-set	271..358	CDD:369462	31/86 (36%)
		I-set	367..454	CDD:369462	32/88 (36%)
		Ig3_Peroxidasin	471..544	CDD:143222	23/74 (31%)
		Ig4_Peroxidasin	567..635	CDD:143223	29/75 (39%)
		peroxidasin_like	889..1328	CDD:188658	259/439 (59%)
		VWC	1439..1494	CDD:214564	24/57 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840093
Domainoid	1	1.000	674	1.000	Domainoid score	I146
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33907
Inparanoid	1	1.050	1165	1.000	Inparanoid score	I203
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46064
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	1	1.000	-	-		oto92544
orthoMCL	1	0.900	-	-		OOG6_105829
Panther	1	1.100	-	-	O	PTHR11475
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2739
SonicParanoid	1	1.000	-	-		X2950
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800