DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pxn and Hmcn2

DIOPT Version :10

Sequence 1:NP_523891.2 Gene:Pxn / 38326 FlyBaseID:FBgn0011828 Length:1527 Species:Drosophila melanogaster
Sequence 2:XP_006498564.1 Gene:Hmcn2 / 665700 MGIID:2677838 Length:5092 Species:Mus musculus


Alignment Length:1086 Identity:252/1086 - (23%)
Similarity:391/1086 - (36%) Gaps:327/1086 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 SVYCPAGCTCLERTVRCIRAKLSAVPKLP--QDTQTLDLRFNH--IEELPANAFSGLAQLTTLFL 83
            :.|.||...|        .|:.|..|.:.  :|.|.||||...  ...||:||         |||
Mouse  3802 TAYSPASLPC--------EARGSPKPLVTWWKDGQKLDLRLQQGAYRLLPSNA---------LFL 3849

  Fly    84 NDNELAYLQDGALNGLTALRFVYLNNNRLS----------RLPATIFQ-----RMPRLEAIFLEN 133
            .   ....||.|       :|..:.:|.:.          .:|.||..     .:.|:..:.|..
Mouse  3850 T---APSPQDSA-------QFECVVSNEVGESRRRYQVTVHVPPTIADDQTHFTVTRMAPVILTC 3904

  Fly   134 NDIWQ-LPAGLFDNLPRLNRLIMYNNKLTQLPVDGFN-RLNNLKRLRLDGNAIDCNCGVYSLWRR 196
            :.... .||            :.::...|||...|.. |:.....|.:: .|:..:.|.|:...|
Mouse  3905 HSTGSPTPA------------VSWSKAGTQLGARGSGYRILPSGALEIE-RALPLHAGRYTCTAR 3956

  Fly   197 WHLDVQRQLVSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVELSCEVTG 261
            ....|.|:.:.:::.                      |.|.....|...||.|.|:|.|.||.:|
Mouse  3957 NSAGVARKHMVLTVQ----------------------ASPVVKPLPSVVQVVASEEVLLPCEASG 3999

  Fly   262 LPRPQITWMHNTQELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQPVRLVV- 325
            :|:|.:.|  ..:.|.:.|.|..::||||.|.|..|...|.|.|.|||:|.:|:..:: .|||| 
Mouse  4000 IPQPMVIW--QKEGLSIPEGAHMQVLPSGQLRIMHASPEDAGNYFCIAQNSVGSAMAK-TRLVVQ 4061

  Fly   326 ------NG--------GNHPLDSPIDARSNQ----VWADAGTPMHGATPLPSPLPSPPHFTHQPH 372
                  ||        |:|.| .|..|:.:.    .|...|..:.||         ...||.||.
Mouse  4062 VPPVIENGLPDLSTIEGSHAL-LPCTAKGSPEPAITWEKDGHLVSGA---------EGKFTLQPS 4116

  Fly   373 DQIVALHGSG--------------------------------------------HVLLDCAASGW 393
            .:::..:..|                                            .:.|.|.|.|.
Mouse  4117 GELLVKNSEGQDAGTYICTAENAVGRARRRVHLTILTLPVLTTLPGDRSLRLGDRLWLRCVARGS 4181

  Fly   394 PQPDIQWFVNGRQLLQSTPSLQLQANGSLILLQPNQLS---AGTYRCEARNSLGSVQATARIELK 455
            |.|.|.|.:|.:.:   |..:..|..||  .||...::   :|||.|.|.|.:|.|||.:.:.:|
Mouse  4182 PTPRIGWTINDQPV---TEGVSEQDGGS--TLQRAAVTREDSGTYTCWAENRVGRVQAVSFVHVK 4241

  Fly   456 ELPEILTAPQSQTIK-LGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQLENENTELVVGAA 519
            |.|.:.....|..:: :|.:..|.|...|:|.|.|.|..:|:|||.:....||:|.:  |.:...
Mouse  4242 EAPVLQGEAFSYLVEPVGGSIQLHCVVRGDPAPDIHWTKDGLPLPISRLHFQLQNGS--LTILRT 4304

  Fly   520 RQEHAGVYRCTAHNENGETSVEATIKVERSQSPPQLAIEPSNLVAITGTTIELPCQADQPEDGLQ 584
            :.:.||.|:|.|.||.|......|:.:   ||.|...:||.::...:|..:||.|:| ..|....
Mouse  4305 KMDDAGRYQCLAVNEMGTVKKVVTVVL---QSAPVFQVEPQDVTVRSGVDVELRCRA-TGEPVPT 4365

  Fly   585 ISWRHDGRLIDPNVQLAEKYQISGAGSLFVKNVTIPDGGRYECQLKNQFGRASASALVTIRNNVD 649
            |.|...||    .:|...|.:....|||::::|...|.|.|||...|..|..:|.||:.:|..  
Mouse  4366 IEWLRAGR----PLQAGRKLRALPDGSLWLEHVEAGDAGVYECVAHNHLGSVTAKALLAVRGE-- 4424

  Fly   650 LAPGDRYVRIAFAEAAKEIDLAINNTLDMLFSNRSD---------KAPPNYGELLRV-------- 697
              |......:......:|..:|..| :.:|....|:         :.|.:.|.|:||        
Mouse  4425 --PRGSRGSMTGVINGQEFGMATLN-ISVLQQGSSEAPTIWSSISQVPASVGPLMRVLVVTIAPI 4486

  Fly   698 ---------------------------FRFPTGE---ARQLARAAEIYERTLVNIR------KHV 726
                                       ..|.|||   ..|:||..:.....||:::      :.:
Mouse  4487 YWALARESGEALNGYSLTGGSFQQESQMEFSTGELLTMTQVARGLDPDGLLLVDMKINGMIPESL 4551

  Fly   727 QEGDNLTMKSEEYEFRDLLSREHL------HLVAELSGCMEHREMPNCTDMCFHS-RYRSIDGTC 784
            .:||   ::.::::       ||.      .|.|..:....|..:| .:..|.|| :|   |.| 
Mouse  4552 ADGD---LRVQDFQ-------EHYVQTGPGQLFAGSTQRFLHDSLP-ASLRCNHSIQY---DET- 4601

  Fly   785 NNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARLVS---TSLVATKE--- 843
                           |.|.|.:.::        .:....|....|.|..::   |:.:.|:|   
Mouse  4602 ---------------RGLQPQLVQH--------LRASSISSAFDPEAEALNFQLTTALQTEENEV 4643

  Fly   844 -----ITPDARITHMVMQWGQF-LDHDLDHAIPSVSSESWDGIDCKKSCEMAPPCYPIEVPPN-- 900
                 ..||.:        |.| :|.|.....||         .|..:|..||..:....|..  
Mouse  4644 GCPEGFEPDVQ--------GAFCVDKDECSGGPS---------PCSHTCRNAPGHFSCSCPTGFS 4691

  Fly   901 ---DPRVRNRRCIDVVRSSAICGSGMTSLFFDSVQHREQINQLTSY 943
               |    :|.|.||..    | :|.|.|   ..:.:..:|.|.||
Mouse  4692 LAWD----HRNCRDVDE----C-AGNTHL---CQEEQRCVNLLGSY 4725

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PxnNP_523891.2 leucine-rich repeat 54..77 CDD:275380 9/24 (38%)
LRR <55..>184 CDD:443914 30/147 (20%)
leucine-rich repeat 78..101 CDD:275380 6/22 (27%)
leucine-rich repeat 102..125 CDD:275380 5/37 (14%)
leucine-rich repeat 126..149 CDD:275380 3/23 (13%)
leucine-rich repeat 150..173 CDD:275380 5/23 (22%)
Ig_3 235..311 CDD:464046 30/75 (40%)
Ig 366..450 CDD:472250 30/130 (23%)
Ig strand B 384..388 CDD:409544 1/3 (33%)
Ig strand C 397..401 CDD:409544 1/3 (33%)
Ig strand E 420..424 CDD:409544 2/3 (67%)
Ig strand F 434..439 CDD:409544 3/4 (75%)
Ig strand G 447..450 CDD:409544 2/2 (100%)
Ig_3 458..533 CDD:464046 23/75 (31%)
Ig 553..644 CDD:472250 29/90 (32%)
Ig strand B 570..574 CDD:409353 2/3 (67%)
Ig strand C 584..588 CDD:409353 1/3 (33%)
Ig strand E 610..614 CDD:409353 3/3 (100%)
Ig strand F 624..629 CDD:409353 3/4 (75%)
Ig strand G 638..641 CDD:409353 1/2 (50%)
peroxidasin_like 898..1338 CDD:188658 14/51 (27%)
VWC 1465..1523 CDD:278520
Hmcn2XP_006498564.1 ChlD <3..208 CDD:440853
Ig <449..514 CDD:472250
Ig strand C 458..462 CDD:409405
Ig strand E 480..484 CDD:409405
Ig strand F 494..499 CDD:409405
Ig strand G 507..510 CDD:409405
IG_like 525..605 CDD:214653
Ig strand B 535..539 CDD:409544
Ig strand C 548..552 CDD:409544
Ig strand E 571..575 CDD:409544
Ig strand F 585..590 CDD:409544
Ig strand G 598..601 CDD:409544
I-set 609..693 CDD:400151
Ig strand B 626..630 CDD:409353
Ig strand C 639..643 CDD:409353
Ig strand E 661..665 CDD:409353
Ig strand F 675..680 CDD:409353
Ig strand G 689..692 CDD:409353
IG_like 707..783 CDD:214653
Ig strand B 716..720 CDD:409353
Ig strand C 729..733 CDD:409353
Ig strand E 749..753 CDD:409353
Ig strand F 763..768 CDD:409353
IG_like 793..876 CDD:214653
Ig strand B 804..808 CDD:409390
Ig strand C 817..821 CDD:409390
Ig strand E 842..846 CDD:409390
Ig strand F 856..861 CDD:409390
Ig strand G 869..872 CDD:409390
I-set 889..969 CDD:400151
Ig strand B 899..903 CDD:409550
Ig strand C 913..917 CDD:409550
Ig strand F 949..954 CDD:409550
Ig strand G 962..965 CDD:409550
Ig_3 972..1046 CDD:464046
Ig 1076..1157 CDD:472250
Ig strand B 1087..1091 CDD:409544
Ig strand C 1100..1104 CDD:409544
Ig strand E 1123..1127 CDD:409544
Ig strand F 1137..1142 CDD:409544
Ig strand G 1150..1153 CDD:409544
Ig 1161..1242 CDD:472250
Ig strand B 1178..1182 CDD:409420
Ig strand C 1191..1195 CDD:409420
Ig strand E 1206..1213 CDD:409420
Ig strand F 1222..1227 CDD:409420
Ig strand G 1235..1238 CDD:409420
Ig 1260..1336 CDD:472250
Ig strand B 1265..1269 CDD:409358
Ig strand C 1278..1282 CDD:409358
Ig strand E 1302..1306 CDD:409358
Ig strand F 1316..1321 CDD:409358
Ig strand G 1329..1332 CDD:409358
I-set 1345..1429 CDD:400151
Ig strand B 1359..1363 CDD:409353
Ig strand C 1372..1376 CDD:409353
Ig strand E 1395..1399 CDD:409353
Ig strand F 1409..1414 CDD:409353
Ig strand G 1422..1425 CDD:409353
I-set 1449..1523 CDD:400151
Ig strand B 1452..1456 CDD:409544
Ig strand C 1465..1469 CDD:409544
Ig strand E 1488..1493 CDD:409544
Ig strand F 1503..1508 CDD:409544
IG_like 1553..1633 CDD:214653
Ig strand B 1563..1567 CDD:409353
Ig strand C 1576..1580 CDD:409353
Ig strand E 1599..1603 CDD:409353
Ig strand F 1613..1618 CDD:409353
Ig 1643..1728 CDD:472250
Ig strand B 1657..1661 CDD:409400
Ig strand C 1670..1674 CDD:409400
Ig strand E 1692..1696 CDD:409400
Ig strand F 1706..1711 CDD:409400
Ig strand G 1721..1724 CDD:409400
Ig 1741..1819 CDD:472250
Ig strand B 1749..1753 CDD:409353
Ig strand C 1762..1766 CDD:409353
Ig strand E 1784..1789 CDD:409353
Ig strand F 1799..1804 CDD:409353
Ig strand G 1812..1815 CDD:409353
Ig 1839..1903 CDD:472250
Ig strand B 1841..1845 CDD:409353
Ig strand C 1854..1858 CDD:409353
Ig strand E 1869..1873 CDD:409353
Ig strand F 1883..1888 CDD:409353
I-set 1907..1986 CDD:400151
Ig strand B 1924..1928 CDD:409562
Ig strand C 1937..1941 CDD:409562
Ig strand E 1960..1964 CDD:409562
Ig strand F 1974..1979 CDD:409562
Ig strand G 1987..1990 CDD:409562
Ig_3 1997..2073 CDD:464046
Ig_3 2091..2166 CDD:464046
Ig 2183..2273 CDD:472250
Ig strand B 2201..2205 CDD:409420
Ig strand C 2214..2218 CDD:409420
Ig strand E 2239..2243 CDD:409420
Ig strand F 2253..2258 CDD:409420
Ig strand G 2266..2269 CDD:409420
Ig 2291..2367 CDD:472250
Ig strand B 2297..2301 CDD:409544
Ig strand C 2310..2314 CDD:409544
Ig strand E 2333..2337 CDD:409544
Ig strand F 2347..2352 CDD:409544
Ig strand G 2360..2363 CDD:409544
Ig 2380..2461 CDD:472250
Ig strand B 2391..2395 CDD:409353
Ig strand C 2404..2408 CDD:409353
Ig strand E 2426..2431 CDD:409353
Ig strand F 2441..2446 CDD:409353
Ig strand G 2454..2457 CDD:409353
I-set 2476..2554 CDD:400151
Ig strand B 2484..2488 CDD:409353
Ig strand C 2497..2501 CDD:409353
Ig strand E 2520..2524 CDD:409353
Ig strand F 2534..2539 CDD:409353
I-set 2558..2650 CDD:400151
Ig strand B 2580..2584 CDD:409393
Ig strand C 2593..2597 CDD:409393
Ig strand E 2617..2620 CDD:409393
Ig strand F 2630..2635 CDD:409393
Ig strand G 2643..2646 CDD:409393
I-set 2668..2740 CDD:400151
Ig strand B 2678..2682 CDD:409353
Ig strand C 2691..2695 CDD:409353
Ig strand E 2714..2718 CDD:409353
Ig strand F 2728..2733 CDD:409353
Ig 2782..2859 CDD:472250
Ig strand B 2789..2793 CDD:409353
Ig strand C 2802..2806 CDD:409353
Ig strand E 2827..2831 CDD:409353
Ig strand F 2839..2844 CDD:409353
Ig strand G 2852..2855 CDD:409353
I-set 2876..2954 CDD:400151
Ig strand B 2884..2888 CDD:409562
Ig strand C 2897..2901 CDD:409562
Ig strand E 2920..2924 CDD:409562
Ig strand F 2934..2939 CDD:409562
Ig strand G 2947..2950 CDD:409562
I-set 2966..3046 CDD:400151
Ig strand B 2976..2980 CDD:409353
Ig strand C 2989..2993 CDD:409353
Ig strand E 3012..3016 CDD:409353
Ig strand F 3026..3031 CDD:409353
I-set 3050..3141 CDD:400151
Ig strand B 3071..3075 CDD:409353
Ig strand C 3084..3088 CDD:409353
Ig strand E 3107..3111 CDD:409353
Ig strand F 3121..3126 CDD:409353
Ig strand G 3134..3137 CDD:409353
Ig 3145..3233 CDD:472250
Ig strand B 3163..3167 CDD:409353
Ig strand C 3176..3180 CDD:409353
Ig strand E 3199..3203 CDD:409353
Ig strand F 3213..3218 CDD:409353
Ig_3 3236..3315 CDD:464046
Ig 3347..3422 CDD:472250
Ig strand B 3352..3356 CDD:409353
Ig strand C 3365..3369 CDD:409353
Ig strand E 3389..3392 CDD:409353
Ig strand F 3402..3407 CDD:409353
Ig 3436..3511 CDD:472250
Ig strand B 3445..3449 CDD:409544
Ig strand C 3458..3462 CDD:409544
Ig strand E 3476..3481 CDD:409544
Ig strand F 3491..3496 CDD:409544
Ig strand G 3504..3507 CDD:409544
Ig 3529..3602 CDD:472250
Ig strand B 3534..3538 CDD:409353
Ig strand C 3547..3551 CDD:409353
Ig strand E 3568..3572 CDD:409353
Ig strand F 3582..3587 CDD:409353
Ig 3614..3695 CDD:472250
Ig strand B 3625..3629 CDD:409394
Ig strand C 3638..3642 CDD:409394
Ig strand E 3661..3665 CDD:409394
Ig strand F 3675..3680 CDD:409394
Ig strand G 3688..3691 CDD:409394
I-set 3699..3786 CDD:400151
Ig strand B 3716..3720 CDD:409353
Ig strand C 3729..3733 CDD:409353
Ig strand E 3753..3756 CDD:409353
Ig strand F 3766..3771 CDD:409353
Ig strand G 3779..3782 CDD:409353
Ig 3790..3881 CDD:472250 25/105 (24%)
Ig strand B 3807..3811 CDD:409490 1/3 (33%)
Ig strand C 3820..3824 CDD:409490 0/3 (0%)
Ig strand E 3845..3849 CDD:409490 3/12 (25%)
Ig strand F 3859..3864 CDD:409490 1/4 (25%)
Ig strand G 3873..3877 CDD:409490 0/3 (0%)
Ig 3900..3970 CDD:472250 15/82 (18%)
Ig strand B 3900..3904 CDD:409544 1/3 (33%)
Ig strand C 3913..3917 CDD:409544 1/15 (7%)
Ig strand E 3936..3940 CDD:409544 1/3 (33%)
Ig strand F 3950..3955 CDD:409544 1/4 (25%)
Ig strand G 3963..3966 CDD:409544 1/2 (50%)
I-set 3974..4060 CDD:400151 34/88 (39%)
Ig strand B 3991..3995 CDD:409560 2/3 (67%)
Ig strand C 4004..4008 CDD:409560 1/5 (20%)
Ig strand E 4026..4030 CDD:409560 2/3 (67%)
Ig strand F 4040..4045 CDD:409560 2/4 (50%)
Ig 4064..4151 CDD:472250 16/96 (17%)
Ig strand B 4081..4085 CDD:409353 1/4 (25%)
Ig strand C 4094..4098 CDD:409353 0/3 (0%)
Ig strand E 4117..4121 CDD:409353 0/3 (0%)
Ig strand F 4131..4136 CDD:409353 0/4 (0%)
Ig strand G 4144..4147 CDD:409353 0/2 (0%)
I-set 4155..4240 CDD:400151 25/89 (28%)
Ig strand C 4185..4189 CDD:409353 1/3 (33%)
Ig strand E 4206..4210 CDD:409353 2/5 (40%)
Ig strand F 4220..4225 CDD:409353 3/4 (75%)
Ig strand G 4234..4237 CDD:409353 1/2 (50%)
Ig_3 4244..4318 CDD:464046 23/75 (31%)
Ig 4336..4421 CDD:472250 28/89 (31%)
Ig strand B 4352..4356 CDD:409544 2/3 (67%)
Ig strand C 4365..4369 CDD:409544 1/3 (33%)
Ig strand E 4387..4391 CDD:409544 3/3 (100%)
Ig strand F 4401..4406 CDD:409544 3/4 (75%)
Ig strand G 4414..4417 CDD:409544 1/2 (50%)
nidG2 4423..4639 CDD:469646 41/258 (16%)
FXa_inhibition 4664..4699 CDD:464251 9/47 (19%)
EGF_CA 4701..4745 CDD:214542 10/33 (30%)
EGF_CA 4746..4783 CDD:214542
EGF_CA 4789..4829 CDD:214542
EGF_CA 4896..4935 CDD:214542
EGF_CA 4936..4974 CDD:214542
Blue background indicates that the domain is not in the aligned region.

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