DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pxn and PTGS2

DIOPT Version :9

Sequence 1:NP_523891.2 Gene:Pxn / 38326 FlyBaseID:FBgn0011828 Length:1527 Species:Drosophila melanogaster
Sequence 2:NP_000954.1 Gene:PTGS2 / 5743 HGNCID:9605 Length:604 Species:Homo sapiens


Alignment Length:656 Identity:139/656 - (21%)
Similarity:219/656 - (33%) Gaps:224/656 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   744 LLSREHLHLVAELSGCMEHREMPNCTDMCFHSRYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYE 808
            :|:|. |.|.|.|:  :.|...|.|:..|.:.      |.|.::....:....|     ....|.
Human     1 MLARA-LLLCAVLA--LSHTANPCCSHPCQNR------GVCMSVGFDQYKCDCT-----RTGFYG 51

  Fly   809 NGFSMPVGWTKGMLYSGHAKPSARLVSTSLVATKEITPDARITHMVMQWG-----QFLDHDL--- 865
            ...|.|...|:..|:   .||:...|...|            ||....|.     .||.:.:   
Human    52 ENCSTPEFLTRIKLF---LKPTPNTVHYIL------------THFKGFWNVVNNIPFLRNAIMSY 101

  Fly   866 -----DHAIPSVSS-------ESWDGIDCKKSCEMAPPCYPIEVP-----------PNDPRVRNR 907
                 .|.|.|..:       :||:..........|.|..|.:.|           |:...:..:
Human   102 VLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEK 166

  Fly   908 RCIDVVRSSAI---CGSGMTSLFFDSVQHREQ-------------INQLTSYIDASQVYGYSTAF 956
            .   ::|...|   .||.|...||  .||...             .|.|...:|.:.:||.:.|.
Human   167 L---LLRRKFIPDPQGSNMMFAFF--AQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLAR 226

  Fly   957 AQELRNLTSQEGLLRVG------------------VHFPRQKDMLPFAAPQDGMDCRRNLDENTM 1003
            .::||  ..::|.::..                  ::.|:..:.|.||..|:             
Human   227 QRKLR--LFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQE------------- 276

  Fly  1004 SCFVSGDIRVNEQVGLLAMHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQ 1068
               |.|.:     .||:...|||:|||||:...|||.:..|..:.|:|.:|.|            
Human   277 ---VFGLV-----PGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLI------------ 321

  Fly  1069 WLPLIIGESGMEMMGEY----QGY------NPQL--------NPSIANEFATAALRFGHTIINPI 1115
                :|||:...::.:|    .||      :|:|        ...||.||.|  |...|.:    
Human   322 ----LIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNT--LYHWHPL---- 376

  Fly  1116 LHRLNETFQPIPQGHLLLHKAFFAPWRLAYEGGVDPLMRGFLAVPAKLKTPDQNLNTELTEKLFQ 1180
               |.:|||...|.:  .::.|.....:..|.|:...:..|....|......:|: ....:|:.|
Human   377 ---LPDTFQIHDQKY--NYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNV-PPAVQKVSQ 435

  Fly  1181 TAHAVALDLAAINIQRGRDHGMPGYNVYRKLCNLTVAQDFEDLAGEISSAEIRQKMKELYGHPDN 1245
            .           :|.:.|......:|.|||...|...:.||:|.||   .|:..:::.|||..|.
Human   436 A-----------SIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGE---KEMSAELEALYGDIDA 486

  Fly  1246 VDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLRDGDRLYYENPGVFSPEQLTQIKQANFGRVLC 1310
            |:                  |:..||||:.|                 |:       |.||..:.
Human   487 VE------------------LYPALLVEKPR-----------------PD-------AIFGETMV 509

  Fly  1311 DVGDNF 1316
            :||..|
Human   510 EVGAPF 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PxnNP_523891.2 LRR_RI 51..>161 CDD:238064
leucine-rich repeat 54..77 CDD:275380
LRR_8 55..112 CDD:290566
leucine-rich repeat 78..101 CDD:275380
leucine-rich repeat 102..125 CDD:275380
LRR_8 124..184 CDD:290566
leucine-rich repeat 126..149 CDD:275380
LRR_4 148..185 CDD:289563
leucine-rich repeat 150..173 CDD:275380
Ig 240..325 CDD:299845
IG_like 242..325 CDD:214653
I-set 366..450 CDD:254352
Ig 384..451 CDD:143165
I-set 458..546 CDD:254352
Ig 472..536 CDD:299845
I-set 553..644 CDD:254352
Ig 570..643 CDD:299845
An_peroxidase 777..1317 CDD:281139 129/623 (21%)
peroxidasin_like 898..1338 CDD:188658 104/482 (22%)
VWC 1465..1523 CDD:278520
PTGS2NP_000954.1 EGF_CA 19..54 CDD:238011 7/45 (16%)
prostaglandin_endoperoxide_synthase 75..562 CDD:188648 118/565 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2408
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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