DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxn and cntn4

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	NP_001073520.1	Gene:	cntn4 / 571349	ZFINID:	ZDB-GENE-060929-776	Length:	1028	Species:	Danio rerio

Alignment Length:	559	Identity:	134/559 - (23%)
Similarity:	204/559 - (36%)	Gaps:	141/559 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 WHLDVQRQLVSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVELSCEVTG 261
            |.|.|.:..    |.|.|...|||..||.         :|..:|:|.|: :....:|..|||..|
Zfish     5 WKLLVLQSF----LGCLAGNALQNLVFSK---------QPGSIVSPVDS-MEKSREVVFSCEAQG 55

  Fly   262 LPRPQITWMHNTQELGLEEQAQAEILPSGSLLIRSADTS-DMGIYQCIARNEMGALRSQPVRL-- 323
            .|.|...|..|...:. .:......|..|:|.|...:.. |.|.|||:|.|..|.:.|:...|
Zfish    56 DPPPFYRWKLNGSVVN-PKPGSHHSLTGGNLRINHLNKDMDAGTYQCLASNSFGTIVSREASLTF 119

  Fly   324 --VVNGGNHPLDSPIDARSNQ-VWADAGTPMH-GA------------------------------ 354
              :.|...|...| :..|..| |....|.|.| ||
Zfish   120 AYLENFKTHKRSS-VSVREGQGVVLLCGPPPHSGALTFSWIFNEYPSIVKQDSRRFVSQETGNLY 183

  Fly   355 ----------------------TPLPSPLPSP-------------PHFTHQPHDQIVALHGSGHV 384
                                  |.:..| |:|             |....| ..::|.:.....|
Zfish   184 IAKVEPSDVGNYTCVVTNTVTKTQVQGP-PTPLILRTDGVMGEYEPKIEVQ-FPEVVQVAKGSTV 246

  Fly   385 LLDCAASGWPQPDIQWFVNGRQLLQSTPSLQ----LQANGSLILLQPNQLSAGTYRCEARNSLGS 445
            .|:|.|.|.|.|.|.|     :.:...|..:    .:.:|.:.:....|..||||.|.|.||.|.
Zfish   247 RLECFALGNPVPSISW-----RRVDGVPFARKVDVRKTSGVMEIPYFQQEDAGTYECVAENSKGR 306

  Fly   446 VQATARIELKELPEILTAPQSQTIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQLENE 510
            .....::.....|:::..||.....:..:.|.||.|.|.|.|:..|..||       .:|:...|
Zfish   307 NSVQGKLSFFASPQLIEKPQDVQKPIDDSLVWECKATGKPKPSYRWMKNG-------ENLEPTEE 364

  Fly   511 NTELVVGAARQEH-----AGVYRCTAHNENGETSVEATIKVERSQSPPQLAIEP--------SNL 562
            ..:::.||....|     .|:|:|.|.|:.||....|.::|        :|:.|        |:.
Zfish   365 RVQVINGALSITHLALSDIGMYQCVAGNKYGEVYSNAELRV--------IAVAPDFSQNQLKSHT 421

  Fly   563 VAITGTTIELPCQADQPEDGLQISWRHDGRLIDPNVQLAEKYQISGAGSLFVKNVTIPDGGRYEC 627
            :...|..:.:.|:......| .||||.....:..:.::|    :..:|||.:.||:..|.|.|.|
Zfish   422 LVKEGGDVLIECKPKMSPRG-SISWRKGNDALRESSRIA----VLESGSLRISNVSKSDAGSYTC 481

  Fly   628 QLKNQFGRASA---------SALVTIRNNVDLAPGDRYV 657
            ..:||||.||:         :.:.|..|.:|:..|:..:
Zfish   482 VARNQFGEASSLGNLLVKEPTIITTAPNTLDVTVGESII 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064
		leucine-rich repeat	54..77	CDD:275380
		LRR_8	55..112	CDD:290566
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380
		LRR_8	124..184	CDD:290566
		leucine-rich repeat	126..149	CDD:275380
		LRR_4	148..185	CDD:289563
		leucine-rich repeat	150..173	CDD:275380
		Ig	240..325	CDD:299845	26/89 (29%)
		IG_like	242..325	CDD:214653	25/87 (29%)
		I-set	366..450	CDD:254352	23/87 (26%)
		Ig	384..451	CDD:143165	21/70 (30%)
		I-set	458..546	CDD:254352	26/92 (28%)
		Ig	472..536	CDD:299845	20/68 (29%)
		I-set	553..644	CDD:254352	26/107 (24%)
		Ig	570..643	CDD:299845	22/81 (27%)
		An_peroxidase	777..1317	CDD:281139
		peroxidasin_like	898..1338	CDD:188658
		VWC	1465..1523	CDD:278520
cntn4	NP_001073520.1	I-set	26..118	CDD:254352	28/102 (27%)
		Ig	26..116	CDD:299845	28/100 (28%)
		Ig	121..216	CDD:299845	15/96 (16%)
		IG_like	131..207	CDD:214653	9/76 (12%)
		Ig	228..316	CDD:299845	24/93 (26%)
		I-set	228..309	CDD:254352	24/86 (28%)
		I-set	319..405	CDD:254352	26/92 (28%)
		Ig	320..405	CDD:299845	25/91 (27%)
		I-set	410..498	CDD:254352	25/92 (27%)
		Ig	426..498	CDD:299845	23/76 (30%)
		I-set	504..597	CDD:254352	4/17 (24%)
		Ig	517..601	CDD:299845	0/4 (0%)
		FN3	601..693	CDD:238020
		FN3	707..799	CDD:238020
		FN3	808..901	CDD:238020
		FN3	893..994	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910