DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxn and Tpo

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	NP_062226.2	Gene:	Tpo / 54314	RGDID:	3900	Length:	914	Species:	Rattus norvegicus

Alignment Length:	777	Identity:	302/777 - (38%)
Similarity:	436/777 - (56%)	Gaps:	79/777 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   668 IDLAINNTLDMLFSNRSDKAPPNYGELLRVFRFPTGEARQLARAAEIYERTLVNIRKHVQEGDNL 732
            :|.|:.||:......|...:|   .:||...:.|...:..::|||||.|.::            .
  Rat    50 VDNAVYNTMKRNLKKRGVLSP---AQLLSFSKLPESTSGAISRAAEIMETSI------------Q 99

  Fly   733 TMKSEEYEF-RDLLSREHLHLVAELSGCMEHREMPNCTDMCFHSRYRSIDGTCNNLQHPTWGASL 796
            .||.|:.:| .|.||.:.|..:|.||||:.....|.|.|.|..::||.|.|.|||..||.||||.
  Rat   100 VMKREQSQFSTDALSADILATIANLSGCLPFMLPPRCPDTCLANKYRPITGVCNNRDHPRWGASN 164

  Fly   797 TAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARLVSTSL--VATKEITPDARITHMVMQWGQ 859
            ||..|..||:||:|||.|.||....||.|...|..|.|:..|  |:.:.:|.|.:.:..:..|||
  Rat   165 TALARWLPPVYEDGFSQPRGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTEDDQYSDFLPVWGQ 229

  Fly   860 FLDHDLDHAIPSVSSES-WDGIDCKKSCEMAPPCYPIEVPPNDPRVRNRRCIDVVRSSAICGSGM 923
            ::|||:.....|.|:.: |.|:||:.:||...||:||::|.|..  |...|:...||||.||:|.
  Rat   230 YIDHDIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPSNSS--RTTACLPFYRSSAACGTGD 292

  Fly   924 TSLFF---DSVQHREQINQLTSYIDASQVYGYSTAFAQELRNLTSQEGLLRVG-VHFPRQKDMLP 984
            ....|   .:...|:|:|.|||::|||.|||.|....::|||.:|..|||||. :|....:..||
  Rat   293 QGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDSGRAYLP 357

  Fly   985 FA----APQDGMDCRRNLDENTMSCFVSGDIRVNEQVGLLAMHTIWMREHNRIASKLKQINSHWD 1045
            ||    ||:.|..     ..|...||::||.|.:|...|.|:||:|:|||||:|:..|.||:||.
  Rat   358 FASAACAPEPGAP-----HANRTPCFLAGDGRASEVPALAAVHTLWLREHNRLATAFKAINTHWS 417

  Fly  1046 GDTLYQEARKIVGAQMQHITFKQWLPLIIG-ESGMEMMGEYQGYNPQLNPSIANEFATAALRFGH 1109
            .:|.||||||:|||..|.||.:.::|.|:| ::..:.:|.|:||||.:||:::|.|:|||.||||
  Rat   418 ANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQYVGPYEGYNPTVNPTVSNVFSTAAFRFGH 482

  Fly  1110 TIINPILHRLNETFQ---PIPQGHLLLHKAFFAPWRLAYEGGVDPLMRGFLAVPAKLKTPDQNLN 1171
            ..::|::.|||..||   .:|:  |.||..||.||||..|||:||::||.||.||||:..:|.:|
  Rat   483 ATVHPLVRRLNTDFQDHTELPR--LQLHDVFFRPWRLIQEGGLDPIVRGLLARPAKLQVQEQLMN 545

  Fly  1172 TELTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYRKLCNLTVAQDFEDLAGEISSAEIRQKM 1236
            .||||:||..::...||||::|:|||||||:||||.:|:.|.|:..:...:|...|::..:..|:
  Rat   546 EELTERLFVLSNVGTLDLASLNLQRGRDHGLPGYNEWREFCGLSRLETPAELNKAIANRSMVNKI 610

  Fly  1237 KELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLRDGDRLYYENPGVFSPEQLTQIK 1301
            .|||.|.||:||||||:.|..:.|.:.||||.|::.:|.:.||||||.::||..||:..|..:::
  Rat   611 MELYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENSHVFTDAQRQELE 675

  Fly  1302 QANFGRVLCDVGDNFDQVTENVFILAKHQGGYKKCEDIIGINLYLWQEC----GRCNSPPAI--- 1359
            :.:..||:|| .....:|..:.|.:.|....::.||:|..::|.||:|.    .:|..|..:
  Rat   676 KHSLPRVICD-NTGLTRVPVDAFRIGKFPQDFESCEEIPSMDLRLWRETFPQDDKCVFPEKVDNG 739

  Fly  1360 -----------------FDSYIPQTYTKRSNRQKRDLGKENDEVATAESYDSPLESLYDVNE 1404
                             |..|..|             |:| ....|...:||......||||
  Rat   740 NFVHCEESGKLVLVYSCFHGYKLQ-------------GQE-QVTCTQNGWDSEPPVCKDVNE 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064
		leucine-rich repeat	54..77	CDD:275380
		LRR_8	55..112	CDD:290566
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380
		LRR_8	124..184	CDD:290566
		leucine-rich repeat	126..149	CDD:275380
		LRR_4	148..185	CDD:289563
		leucine-rich repeat	150..173	CDD:275380
		Ig	240..325	CDD:299845
		IG_like	242..325	CDD:214653
		I-set	366..450	CDD:254352
		Ig	384..451	CDD:143165
		I-set	458..546	CDD:254352
		Ig	472..536	CDD:299845
		I-set	553..644	CDD:254352
		Ig	570..643	CDD:299845
		An_peroxidase	777..1317	CDD:281139	246/554 (44%)
		peroxidasin_like	898..1338	CDD:188658	196/451 (43%)
		VWC	1465..1523	CDD:278520
Tpo	NP_062226.2	An_peroxidase	145..687	CDD:281139	246/551 (45%)
		thyroid_peroxidase	161..722	CDD:188657	245/570 (43%)
		CCP	730..783	CDD:153056	10/66 (15%)
		EGF_CA	784..826	CDD:284955	4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..907
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11475
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920