DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pxn and pxdn

DIOPT Version :9

Sequence 1:NP_523891.2 Gene:Pxn / 38326 FlyBaseID:FBgn0011828 Length:1527 Species:Drosophila melanogaster
Sequence 2:NP_001076815.1 Gene:pxdn / 493201 XenbaseID:XB-GENE-923300 Length:1460 Species:Xenopus tropicalis


Alignment Length:1553 Identity:632/1553 - (40%)
Similarity:896/1553 - (57%) Gaps:134/1553 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 MLLM------LQLLGLLLLLAGGVQSVYCPAGCTCLERTVRCIRAKLSAVPKLPQDTQTLDLRFN 62
            |::|      |.|...||::|....|..||:.|.|...||||:...|.:||.:|..|..||||||
 Frog     1 MMMMAGAGSWLYLTAGLLVVALPQLSHSCPSRCLCFRTTVRCMHLMLESVPAVPPHTTILDLRFN 65

  Fly    63 HIEELPANAFSGLAQLTTLFLNDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPRLE 127
            .|:::...||..|..|.||.||:|::..:...|...|..|:::||..|.:..:....|:.:..||
 Frog    66 RIKDIQTGAFKHLKNLNTLLLNNNQIKRIPSEAFKDLENLKYLYLYKNEIQSIDRQAFKGLASLE 130

  Fly   128 AIFLENNDIWQLPAGLFDNLPRLNRLIMYNNKLTQLPVDGFNRLNNLKRLRLDGNAIDCNCGVYS 192
            .::|..|.|..|....|:.||:|.||.::||::|.|....|::|.::||||||.||:.|:|.:  
 Frog   131 QLYLHFNQIETLEPESFNYLPKLERLFLHNNRITHLVPGTFSQLESMKRLRLDSNALHCDCEI-- 193

  Fly   193 LWRRWHLDVQRQL--VSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVEL 255
            ||....|.:..:.  ...:.||..|:.||.:..|::......|.:|:....|||..|..|..|..
 Frog   194 LWLADLLKIYSESGNAQAAATCEYPRRLQGRSVSTITPSELNCERPRITSEPQDVDVTFGNTVYF 258

  Fly   256 SCEVTGLPRPQITWMHNTQELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQP 320
            :|...|.|:|:|.|:.|..||.:::.::..:|..|:|:|::...:|.|||||:|:|..|.:::..
 Frog   259 TCRAEGNPKPEIIWLRNNNELSMKDDSRLNLLNDGTLMIQNTKETDQGIYQCMAKNVAGEVKTHE 323

  Fly   321 VRLVVNGGNHPLDSPIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQPHDQIVALHGSGHVL 385
            |.|...|                                 .|:.|.|..||.:..|.:..|  |.
 Frog   324 VTLRYYG---------------------------------TPATPTFVIQPQNTEVLVGES--VT 353

  Fly   386 LDCAASGWPQPDIQWFVNGRQLLQSTPSLQLQANGSLILLQPNQLSAGTYRCEARNSLGSVQATA 450
            |:|:|:|.|.|.:.|....|..|.|.|.:.:..:|.|.:...||..||.|.|.|.||:.::.:||
 Frog   354 LECSATGQPHPRVTWTRGDRTPLPSDPRINITPSGGLYIQNVNQDDAGEYTCFATNSVETIHSTA 418

  Fly   451 RIELKELPEILTAPQSQTIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQLENENTELV 515
            .|.::.:|:....||.:.:..|......|:|.|||.|.|.|...|       ..|.::..:..|.
 Frog   419 YIIVQAVPQFTVVPQDRNVFEGHTVDFHCEAQGNPKPVIAWTKGG-------NQLSVDRRHQVLS 476

  Fly   516 VGAAR-----QEHAGVYRCTAHNENGETSVEATIKVERSQSPPQLAIEPSNLVAITGTTIELPCQ 575
            .|..|     ....|.|.|.|.|..|..|..|.:.|: ::..|..|..|:::....||.:::||.
 Frog   477 SGTLRILRVALHDQGQYECQAVNIVGSKSTAAQLIVQ-TRVTPVFATVPNDMTVEVGTDVQIPCS 540

  Fly   576 ADQPEDGLQ-ISWRHDGRLIDPNVQLAE--KYQISGAGSLFVKNVTIPDGGRYECQLKNQFGRAS 637
            :.  .|.|. |:|..||      :|:.|  |:.||..|.|.:::..:.|.|||||..:|..|.:|
 Frog   541 SQ--GDPLPIITWNKDG------IQVTESGKFHISPHGYLAIRDAGLADQGRYECVARNPIGYSS 597

  Fly   638 ASALVTIRNNVDLAP-----GDRYVRIAFAEAAKEIDLAINNTLDMLFSNRSDKAPPNYGELLRV 697
            .|.::::     |.|     ||.:|..:..||...:|.|||:|...||.:|    |.:.|:||.:
 Frog   598 VSMVLSV-----LVPEVSRTGDPFVATSIIEAIATVDRAINSTRTHLFDSR----PRSPGDLLAL 653

  Fly   698 FRFPTGE-ARQLARAAEIYERTLVNIRKHVQEGDNLTMKSEEYEFRDLLSREHLHLVAELSGCME 761
            ||:|... ..:.||||||:||||..|:.|||.|..:.:....|.:.||:|.::|:::|.||||..
 Frog   654 FRYPRDPYTVEQARAAEIFERTLQLIQDHVQSGLMVDLNGTSYHYNDLVSPQYLNMIANLSGCAT 718

  Fly   762 HREMPNCTDMCFHSRYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGH 826
            ||.:.||::||||.:||:.||||||||||.||||||||.||...:|||||::|.| ..|.:|:|.
 Frog   719 HRRINNCSNMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNLPRG-ISGRIYNGF 782

  Fly   827 AKPSARLVSTSLVATKEITPDARITHMVMQWGQFLDHDLDHAIPSVSSESW-DGIDCKKSCEMAP 890
            ..|..|||||:|:.|..||||.:.|||:||||||||||||..:.::|...: ||.||...|....
 Frog   783 PLPLPRLVSTTLIGTHTITPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQDCSVVCTNDA 847

  Fly   891 PCYPIEVPPNDPRVRNR-RCIDVVRSSAICGSGMTSLFFDSVQHREQINQLTSYIDASQVYGYST 954
            ||:||.||||||||||. ||:.:||||.:||||||||..:||..|||:||||||||||.|||.|.
 Frog   848 PCFPIMVPPNDPRVRNNARCMSMVRSSPVCGSGMTSLLMNSVYPREQMNQLTSYIDASNVYGSSD 912

  Fly   955 AFAQELRNLTSQEGLLRVGVHFPRQKDMLPFAAPQDGMDCRRNLDENTMSCFVSGDIRVNEQVGL 1019
            ..:.|:|:..|..|||:.|:.....|.:||||.... .:|.|:.:|:.:.||::||.|.|||:||
 Frog   913 HESNEIRDSASHRGLLKQGIVQRSGKPLLPFATGPP-TECMRDENESPIPCFLAGDHRANEQLGL 976

  Fly  1020 LAMHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEMMGE 1084
            .:|||:|.|||||||::|.::|.||||||:|.|.||||||||||||:..|||.|.|:.||:|:||
 Frog   977 TSMHTLWFREHNRIATELLRLNPHWDGDTIYHETRKIVGAQMQHITYSHWLPKIFGDVGMKMLGE 1041

  Fly  1085 YQGYNPQLNPSIANEFATAALRFGHTIINPILHRLNETFQPIPQGHLLLHKAFFAPWRLAYEGGV 1149
            |:.|:|.:|..|.|||||||.|||||:|||||:||:|.|:||||||:.||:|||:|:|:..|||:
 Frog  1042 YKSYDPNVNAGILNEFATAAFRFGHTLINPILYRLDEKFEPIPQGHVPLHRAFFSPFRIVNEGGI 1106

  Fly  1150 DPLMRGFLAVPAKLKTPDQNLNTELTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYRKLCNL 1214
            |||:||.:.|.||::...|.||||||||||..||||||||||:|:|||||||:|.|:.:|..|||
 Frog  1107 DPLLRGLIGVAAKMRVTSQLLNTELTEKLFSMAHAVALDLAALNVQRGRDHGIPPYHDFRVFCNL 1171

  Fly  1215 TVAQDFEDLAGEISSAEIRQKMKELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLR 1279
            :..|.|:||..||.:.::|:|:|.|||.|.|:|::...::||.:.|.::||...|||..|||.:|
 Frog  1172 STVQTFDDLRNEIKNPDVREKLKRLYGSPLNIDLFPALMVEDLIPGSRLGPTLMCLLTTQFRNIR 1236

  Fly  1280 DGDRLYYENPGVFSPEQLTQIKQANFGRVLCDVGDNFDQVTENVFILAKHQGGYKKCEDIIGINL 1344
            ||||.:|||||||:..|||||||.:..|||||.|||..:|..::|.:|:...||..|::|..::|
 Frog  1237 DGDRFWYENPGVFTAAQLTQIKQTSLARVLCDNGDNITKVQHDLFRVAEFPHGYVSCKNIAKMDL 1301

  Fly  1345 YLWQECGRCNSPPAIFDSYIPQTYTKRSNRQ--KRDLGKE-----NDEVATAESYDSPLESLYDV 1402
            .:||:|.........|.::......|||...  |.| .||     |..|.|..:.:.| ::|..|
 Frog  1302 RVWQDCCEDCRTRGQFSTFSNHFRGKRSTEHSYKED-NKEPSSLLNQSVNTTCNTEQP-KNLPHV 1364

  Fly  1403 NEERVSGLEELIGSFQKELKKLHKKLRKLEDSCNSADSEPVAQVVQLAAAPPQLVSKPKRSHCVD 1467
            |:     .:|.:...||.:..|.|:::|||...::.|                         |.|
 Frog  1365 ND-----FKEFVLDMQKTITGLRKQIKKLESRLSNTD-------------------------CTD 1399

  Fly  1468 DKGTTRLNNEVWSPDVCTKCNCFHGQVNCLRERCGEVSC--PPGVDPLTPPEACCPHC 1523
            :.|.:....|.|:.|.||||.|::|.:.|..:.|..|:|  |..::.:     |||.|
 Frog  1400 ETGESHSTKEKWNKDACTKCECYNGHITCFVKSCPPVNCSRPQRIEGV-----CCPVC 1452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PxnNP_523891.2 LRR_RI 51..>161 CDD:238064 39/109 (36%)
leucine-rich repeat 54..77 CDD:275380 11/22 (50%)
LRR_8 55..112 CDD:290566 22/56 (39%)
leucine-rich repeat 78..101 CDD:275380 8/22 (36%)
leucine-rich repeat 102..125 CDD:275380 5/22 (23%)
LRR_8 124..184 CDD:290566 25/59 (42%)
leucine-rich repeat 126..149 CDD:275380 8/22 (36%)
LRR_4 148..185 CDD:289563 18/36 (50%)
leucine-rich repeat 150..173 CDD:275380 9/22 (41%)
Ig 240..325 CDD:299845 30/84 (36%)
IG_like 242..325 CDD:214653 30/82 (37%)
I-set 366..450 CDD:254352 28/83 (34%)
Ig 384..451 CDD:143165 24/66 (36%)
I-set 458..546 CDD:254352 25/92 (27%)
Ig 472..536 CDD:299845 19/68 (28%)
I-set 553..644 CDD:254352 30/93 (32%)
Ig 570..643 CDD:299845 25/75 (33%)
An_peroxidase 777..1317 CDD:281139 318/541 (59%)
peroxidasin_like 898..1338 CDD:188658 254/440 (58%)
VWC 1465..1523 CDD:278520 20/59 (34%)
pxdnNP_001076815.1 leucine-rich repeat 38..56 CDD:275380 8/17 (47%)
LRR <54..235 CDD:227223 62/182 (34%)
leucine-rich repeat 57..80 CDD:275380 11/22 (50%)
LRR_8 104..163 CDD:338972 19/58 (33%)
leucine-rich repeat 105..128 CDD:275378 5/22 (23%)
leucine-rich repeat 129..152 CDD:275378 8/22 (36%)
leucine-rich repeat 153..176 CDD:275378 9/22 (41%)
leucine-rich repeat 177..189 CDD:275378 8/11 (73%)
I-set 239..326 CDD:369462 30/86 (35%)
I-set 335..422 CDD:369462 32/88 (36%)
Ig3_Peroxidasin 439..512 CDD:143222 22/79 (28%)
Ig4_Peroxidasin 535..603 CDD:143223 25/75 (33%)
peroxidasin_like 856..1295 CDD:188658 253/439 (58%)
VWC 1402..1452 CDD:214564 18/54 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 672 1.000 Domainoid score I144
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H33907
Inparanoid 1 1.050 1154 1.000 Inparanoid score I207
OMA 1 1.010 - - QHG46064
OrthoDB 1 1.010 - - D276568at2759
OrthoFinder 1 1.000 - - FOG0000202
OrthoInspector 1 1.000 - - otm47865
Panther 1 1.100 - - O PTHR11475
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2739
SonicParanoid 1 1.000 - - X2950
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1212.110

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