DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pxn and MPO

DIOPT Version :9

Sequence 1:NP_523891.2 Gene:Pxn / 38326 FlyBaseID:FBgn0011828 Length:1527 Species:Drosophila melanogaster
Sequence 2:NP_000241.1 Gene:MPO / 4353 HGNCID:7218 Length:745 Species:Homo sapiens


Alignment Length:728 Identity:280/728 - (38%)
Similarity:413/728 - (56%) Gaps:45/728 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   637 SASALVTIRNNVDLAPGDRYVRIAFAEAAKEIDLAINNTLDMLFSN-RSDKAPPNYGELLRVFRF 700
            |..|...:...||.:    .|..:..||.:.:|.|.....:.:... ||..|.|.  |||..|:.
Human    46 SEGAAPAVLGEVDTS----LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPM--ELLSYFKQ 104

  Fly   701 PTGEARQLARAAEIYERTLVNIRKHVQEGDNLTMKSEEYEFRDLLSREHLHLVAELSGCMEHREM 765
            |....|...|||:.....|..:.:.::     ::....:...|:|:...|:::::.|||......
Human   105 PVAATRTAVRAADYLHVALDLLERKLR-----SLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVG 164

  Fly   766 PNCTDMCFHSRYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPS 830
            ..|.:   ..:||:|.|.|||.:.||.|||..||.|..|..||:|||:|.|||.|:..:|.....
Human   165 VTCPE---QDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVAL 226

  Fly   831 ARLVSTSLV--ATKEITPDARITHMVMQWGQFLDHDLDHA-IPSVSSESWDGIDCKKSCEMAPPC 892
            ||.||..:|  .|.::|||...:.|.|||||.||||||.. .|:..:....|::|:.||...|||
Human   227 ARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPC 291

  Fly   893 YPIEVPPNDPRVRNRR-CIDVVRSSAIC-GSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTA 955
            :|:::||||||::|:. ||...||...| ||.:|.        |.|||.|||::|||.|||....
Human   292 FPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITI--------RNQINALTSFVDASMVYGSEEP 348

  Fly   956 FAQELRNLTSQEGLLRVGVHF-PRQKDMLPFAAPQDGMDCRRNLDENTMSCFVSGDIRVNEQVGL 1019
            .|:.|||:::|.|||.|...| ...:.:|||....|. .|........:.||::||.|.:|...|
Human   349 LARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDD-PCLLTNRSARIPCFLAGDTRSSEMPEL 412

  Fly  1020 LAMHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGM-EMMG 1083
            .:|||:.:|||||:|::||.:|..|||:.|||||||||||.:|.||::.:|||::|.:.| :.:.
Human   413 TSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLP 477

  Fly  1084 EYQGYNPQLNPSIANEFATAALRFGHTIINPILHRLNETFQPI-PQGHLLLHKAFFAPWRLAYEG 1147
            .|:.||..::|.|||.| |.|.|:|||:|.|.:.||:..:||: |...:.|.:.|||.||:..||
Human   478 TYRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEG 541

  Fly  1148 GVDPLMRGFLAVPAKLKTPDQNLNTELTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYRKLC 1212
            |:||::||.:|.||||...:|....|:.|:||:....:.|||.|:|:||.||||:||||.:|:.|
Human   542 GIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFC 606

  Fly  1213 NLTVAQDFEDLAGEISSAEIRQKMKELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRR 1277
            .|...:....|...:.:.::.:|:.|.||.|:|:|:|:||:.|.....|:||||..|::..|||:
Human   607 GLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRK 671

  Fly  1278 LRDGDRLYYENPGVFSPEQLTQIKQANFGRVLCD------VGDNFDQVTENVFILAKHQGGYKKC 1336
            ||||||.::||.||||.:|...:.|.:..|::||      |..|      |:|:...:...:..|
Human   672 LRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKN------NIFMSNSYPRDFVNC 730

  Fly  1337 EDIIGINLYLWQE 1349
            ..:..:||..|:|
Human   731 STLPALNLASWRE 743

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PxnNP_523891.2 LRR_RI 51..>161 CDD:238064
leucine-rich repeat 54..77 CDD:275380
LRR_8 55..112 CDD:290566
leucine-rich repeat 78..101 CDD:275380
leucine-rich repeat 102..125 CDD:275380
LRR_8 124..184 CDD:290566
leucine-rich repeat 126..149 CDD:275380
LRR_4 148..185 CDD:289563
leucine-rich repeat 150..173 CDD:275380
Ig 240..325 CDD:299845
IG_like 242..325 CDD:214653
I-set 366..450 CDD:254352
Ig 384..451 CDD:143165
I-set 458..546 CDD:254352
Ig 472..536 CDD:299845
I-set 553..644 CDD:254352 2/6 (33%)
Ig 570..643 CDD:299845 2/5 (40%)
An_peroxidase 777..1317 CDD:281139 243/553 (44%)
peroxidasin_like 898..1338 CDD:188658 189/450 (42%)
VWC 1465..1523 CDD:278520
MPONP_000241.1 myeloperoxidase_like 316..728 CDD:188656 177/427 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165150037
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2408
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D276568at2759
OrthoFinder 1 1.000 - - FOG0000202
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11475
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2739
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.880

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