DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxn and CG4009

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	NP_001262655.1	Gene:	CG4009 / 42054	FlyBaseID:	FBgn0038469	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	683	Identity:	204/683 - (29%)
Similarity:	309/683 - (45%)	Gaps:	121/683 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   716 ERTLVNIRKHVQEGDNLTMKSEEYEFRDLLSREHLH-LVAELSGCMEHRE--MP--NCTDMCFHS 775
            :|:..:||..|.:|   ::.:...||....:..::| ..||.|...:...  :|  ||.:...:.
  Fly    32 KRSSFDIRPGVSDG---SLDALIKEFMPKYNGNNVHNSWAEPSASQQPLRCGVPPRNCLNDTRNL 93

  Fly   776 RYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARLVSTSLVA 840
            .||::||:||||.:|.:|.:::.:|||.||                 ......|:|||:|.||..
  Fly    94 HYRTLDGSCNNLLYPEFGIAVSRYRRLLPP-----------------RQVEQAPNARLISLSLYG 141

  Fly   841 TKEITPDARI-THMVMQWGQFLDHDLDHAIPSVSSESWDGI--DCKKSC--EMAPPCYPIEVPPN 900
              |.|.:.|. |...||||||:.||       :|..|..|.  ||   |  ...|.|.||.:|..
  Fly   142 --EQTRNDRFRTMAAMQWGQFVAHD-------ISQLSTQGAPQDC---CAEPRHPRCLPINLPRG 194

  Fly   901 DPRV--RNRRCIDVVRS----SAICGSGMTSLFFDSVQ--HREQINQLTSYIDASQVYGYSTAFA 957
            .|..  ..:.|:...||    .|||         ..|:  ..|::...|:|:|.|.:||.:.:..
  Fly   195 GPIAYHTGKTCLHFARSVSDADAIC---------PKVEEPQPEKLTVATAYLDLSSIYGNNPSQN 250

  Fly   958 QELRNLTSQEGLLRV----GVHFPRQKDMLPFAAPQDGMDCRRNLDENTMSCFVSGDIRVNEQVG 1018
            :::|  ..:.|||:.    |.|:      ||.:..::| :|....:     |::..|||......
  Fly   251 RKVR--LFKGGLLKTSYTNGQHW------LPVSQNENG-ECGAKSE-----CYIVPDIRNRFSPT 301

  Fly  1019 LLAMHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEMMG 1083
            :..:.|:.:|||||:|..|..||.....:.::||||||..||.|.||:..||||.:|.:...:.|
  Fly   302 IALLQTLLVREHNRLAENLALINPDHSDERIFQEARKINIAQFQKITYYDWLPLFVGRTYTYLNG 366

  Fly  1084 --------EY-QGYNPQLNPSIANEFATAALRFGHT-------IINPILHRLNET-----FQPIP 1127
                    || ..|:..:||:...||:.||.|:.||       ::.| ..|.|.|     |....
  Fly   367 LIYPVEPTEYVNDYDETVNPAAYAEFSAAAFRYAHTQIPGWFSLVAP-NRRSNRTMRLSDFLDRT 430

  Fly  1128 QGHLLLHKAFFAPWRLAYEGGVDPLMRGFLAVPAKLKTPDQNLNTEL----TEKLFQTAHAVALD 1188
            :...||..:          ...|.|:|| ||.... |..|.|::.|:    ..|.|:   ....|
  Fly   431 ETIRLLDTS----------DNFDALLRG-LATQLH-KRSDGNIDREIKHYFNRKEFE---EYGSD 480

  Fly  1189 LAAINIQRGRDHGMPGYNVYRKLCNLTVAQDFEDLAGEISSAEIRQKMKELYGHPDNVDVWLGGI 1253
            |.:|:|||.||.|:..||..|:.|.|..|.|:.|.|.||...:| ..::.||..||:|::.:||.
  Fly   481 LKSIDIQRARDFGLASYNDVREFCGLRRAVDWADFAHEIPGEKI-SLLRRLYATPDDVELGVGGT 544

  Fly  1254 LEDQVEGGKVGPLFQCLLVEQFRRLRDGDRLYY--ENPGVFSPEQLTQIKQANFGRVLCDVGDNF 1316
            ||..|.....||...|::.:||...|.|||.::  ||.|.||..||.:|::.:...:.|...:..
  Fly   545 LEYHVPDALFGPTLLCVIGKQFLNTRRGDRFFFERENEGGFSRAQLAEIRKVSLSSLFCSNANYL 609

  Fly  1317 DQVTENVFILAKHQGGYKKCEDIIGINLYLWQE 1349
            ..:..|||:..........|..|..|:|..||:
  Fly   610 HLIQPNVFVFPNSHNLLLNCNFIPQIDLSKWQD 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064
		leucine-rich repeat	54..77	CDD:275380
		LRR_8	55..112	CDD:290566
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380
		LRR_8	124..184	CDD:290566
		leucine-rich repeat	126..149	CDD:275380
		LRR_4	148..185	CDD:289563
		leucine-rich repeat	150..173	CDD:275380
		Ig	240..325	CDD:299845
		IG_like	242..325	CDD:214653
		I-set	366..450	CDD:254352
		Ig	384..451	CDD:143165
		I-set	458..546	CDD:254352
		Ig	472..536	CDD:299845
		I-set	553..644	CDD:254352
		Ig	570..643	CDD:299845
		An_peroxidase	777..1317	CDD:281139	181/583 (31%)
		peroxidasin_like	898..1338	CDD:188658	141/478 (29%)
		VWC	1465..1523	CDD:278520
CG4009	NP_001262655.1	An_peroxidase_like	77..>367	CDD:265428	103/341 (30%)
		An_peroxidase	95..610	CDD:281139	181/583 (31%)
		peroxinectin_like	228..605	CDD:188655	128/407 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454587
Domainoid	1	1.000	107	1.000	Domainoid score	I2172
eggNOG	1	0.900	-	-		E1_KOG2408
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850