DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxn and lrfn1

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	NP_956909.1	Gene:	lrfn1 / 393587	ZFINID:	ZDB-GENE-040426-1227	Length:	584	Species:	Danio rerio

Alignment Length:	448	Identity:	114/448 - (25%)
Similarity:	173/448 - (38%)	Gaps:	93/448 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MLQLLGLLLLLAGGVQSVYCPAGCTCL----ERTVRCIRAKLSAVPKLPQDTQTLDLRF------ 61
            |.:|:..:|:.....::..||..|.|.    ..|:.|.:..|..||. ..|.:|::||.
Zfish     1 MERLVFCVLVFGALAKAQLCPGRCICQTISPTLTLLCAKTGLLFVPP-TVDRKTVELRLTDNFIT 64

  Fly    62 --------------------NHIEELPANAFSGLAQLTTLFLNDNELAYLQDGALNGLTALRFVY 106
                                |.|.::..:||.||..|..|.::.|.|:.:....|.||..||.:.
Zfish    65 AVRRKDFLNMTSLVHLTLSRNTISQIAPHAFMGLKSLRALHMDGNRLSVINSDQLKGLMNLRHLI 129

  Fly   107 LNNNR-------------------------LSRLPATIFQRMPRLEAIFLENNDIWQLPAGLFDN 146
            |.||:                         |..||.....||..:..:.|::|.|..:..|.|..
Zfish   130 LGNNQIHHIEESSFDEFVATIEDLDLSYNNLRTLPWEAIARMTNINTLTLDHNLIDHIGVGTFTL 194

  Fly   147 LPRLNRLIMYNNKLTQLPVDGF---------NRLNNLKRLRLD--GNAIDCNCGVYSLWRRWHLD 200
            |.:|.||.|.:|:|..||.|..         .:.::..||.:.  ||.:.|||.:  ||.| .|.
Zfish   195 LTKLVRLDMTSNRLQTLPPDTLFQHAQVLSEPKTSSSSRLTVSFGGNPLHCNCEL--LWLR-RLT 256

  Fly   201 VQRQLVSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQDA---QVAAGEQVELSCEVTGL 262
            .:..|.    |||:|:.|.::.|.|:.|..|.|..|  |:.....   .|..|:.|.|.|:..|.
Zfish   257 REDDLE----TCASPEHLMDKYFWSIQEEEFICEPP--LITKHQVTKPYVMEGQGVTLKCKAMGD 315

  Fly   263 PRPQITWMHNTQELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQ------PV 321
            |.|.|.|.....:| :...::..:..:|:|.|......|.|.:.|:|.|..|...:.      |:
Zfish   316 PDPAIHWRFPDGKL-VHNNSRTILYDNGTLDILITTLKDSGAFNCVASNAAGIATAAVHVHMIPL 379

  Fly   322 RLVVNGGNH-----PLDSPIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQPHDQ 374
            .|:||...|     |..|.|...|.....|:.|  |....|...|.:.....|.|.::
Zfish   380 PLLVNNTGHMREADPGLSDISTSSRSSSNDSKT--HSKRVLVENLTAHSAVIHWPSER 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064	38/160 (24%)
		leucine-rich repeat	54..77	CDD:275380	9/48 (19%)
		LRR_8	55..112	CDD:290566	21/107 (20%)
		leucine-rich repeat	78..101	CDD:275380	7/22 (32%)
		leucine-rich repeat	102..125	CDD:275380	10/47 (21%)
		LRR_8	124..184	CDD:290566	19/70 (27%)
		leucine-rich repeat	126..149	CDD:275380	6/22 (27%)
		LRR_4	148..185	CDD:289563	13/47 (28%)
		leucine-rich repeat	150..173	CDD:275380	9/31 (29%)
		Ig	240..325	CDD:299845	22/93 (24%)
		IG_like	242..325	CDD:214653	22/91 (24%)
		I-set	366..450	CDD:254352	2/9 (22%)
		Ig	384..451	CDD:143165
		I-set	458..546	CDD:254352
		Ig	472..536	CDD:299845
		I-set	553..644	CDD:254352
		Ig	570..643	CDD:299845
		An_peroxidase	777..1317	CDD:281139
		peroxidasin_like	898..1338	CDD:188658
		VWC	1465..1523	CDD:278520
lrfn1	NP_956909.1	LRR 1	52..73		3/20 (15%)
		LRR_8	55..111	CDD:290566	11/55 (20%)
		leucine-rich repeat	55..76	CDD:275380	2/20 (10%)
		LRR_RI	<71..>208	CDD:238064	34/136 (25%)
		LRR 2	76..97		4/20 (20%)
		leucine-rich repeat	77..100	CDD:275380	6/22 (27%)
		LRR_8	99..160	CDD:290566	12/60 (20%)
		LRR 3	100..121		5/20 (25%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		LRR 4	124..145		5/20 (25%)
		leucine-rich repeat	125..148	CDD:275380	5/22 (23%)
		LRR 5	149..170		3/20 (15%)
		leucine-rich repeat	150..173	CDD:275380	5/22 (23%)
		LRR_8	153..208	CDD:290566	16/54 (30%)
		LRR 6	173..194		5/20 (25%)
		leucine-rich repeat	174..197	CDD:275380	6/22 (27%)
		LRR 7	197..218		9/20 (45%)
		leucine-rich repeat	198..222	CDD:275380	9/23 (39%)
		LRRCT	241..>270	CDD:214507	13/35 (37%)
		IG_like	299..375	CDD:214653	20/76 (26%)
		Ig_2	303..376	CDD:143241	19/73 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..414		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910