DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxn and Lgi4

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	NP_653139.2	Gene:	Lgi4 / 243914	MGIID:	2180197	Length:	537	Species:	Mus musculus

Alignment Length:	602	Identity:	138/602 - (22%)
Similarity:	208/602 - (34%)	Gaps:	201/602 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLLLAGGVQSV-------YCPAGCTCLERTVRCIRAKLSAVPKLPQDTQT----LDLRFNHIEE 66
            ||.|||.....|       .||..|:|.:....|     ...|:||:...|    |.|....:..
Mouse     7 LLFLLAWAGAGVAWSPPKGKCPPHCSCSKENTLC-----EGSPELPESFSTTLLSLSLVRMGVSR 66

  Fly    67 LPANAFSGLAQLTTLFLNDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPRLEAIFL 131
            |.|.:|..:..|..|....|..:.::..|..||:.|::                        :|:
Mouse    67 LKAGSFLKMPSLHLLLFTSNTFSVIEGDAFIGLSYLQY------------------------LFI 107

  Fly   132 ENNDIWQLPAGLFDNLPRLNRLIMYNNKLTQLPVDGFNRLNNLKRLRLDGNAIDCNCGVYSLW-R 195
            |:|.|..:.......|..|..|.:.||.|..||...|..|..|..:.|.||...|:|.|  || .
Mouse   108 EDNKIGSISKNALRGLRSLTHLSLANNHLEALPRFLFRGLETLTHVDLRGNPFQCDCRV--LWLL 170

  Fly   196 RW-------------------------HLDVQRQLVSISLTCAAPQM--LQNQG--------FSS 225
            :|                         |||.::      ..|.|.::  ||..|        ||.
Mouse   171 QWMPTVNASVGTGACAGPPAVAQIQLNHLDPKK------FKCRATELSWLQTVGESALSVESFSY 229

  Fly   226 LGEHHFKCAKPQFLVAPQDAQVAAGEQVELSCEVTGLPRPQITWMHNTQELGLEEQAQAEILPSG 290
            .||.|...|:|           .||.     |.:       :.|.::.|....||:..|..:.|.
Mouse   230 QGEPHMVLAQP-----------FAGR-----CLI-------LVWDYSLQRFRPEEELSAPSVVSC 271

  Fly   291 SLLIRSADTSDMG--IYQCIARNEMGA---------LRSQPVRLVVNGGNHPLDSPIDARSNQVW 344
            ..|:       :|  ::...||...|:         ||..||:::   ....|..|.||  ..:|
Mouse   272 KPLV-------LGPRLFILAARLWGGSQLWSRSSPDLRLTPVQVL---APQRLLRPNDA--ELLW 324

  Fly   345 ADAGTPMH--------GATPL-----PSPLPSPP-HFTHQPHD-QIVALHGSGHVLLDCAASGWP 394
            .| |.|..        |:|.|     |...|... |..|:..| :.:.|.|..|:||   ||...
Mouse   325 LD-GQPCFVVADASKAGSTTLLCRDGPGFYPRQSLHAWHRDTDAEALELDGRPHLLL---ASASQ 385

  Fly   395 QPDIQWFVNGR----------QLLQST------------------PSLQLQANGSLILLQPNQLS 431
            :|.:..:|.||          :.:.:|                  .|:.::.:||:..|.....|
Mouse   386 RPVLFHWVGGRFERRTDIPEAEDVYATKHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPS 450

  Fly   432 AGTYRCE----ARNS---LGSVQATARI-----------ELKEL-PEILTAPQ--SQTIKLGKAF 475
            .|::..:    ||:.   |||..|.:::           .|:|| |..|.||:  :|....|:.|
Mouse   451 RGSHVFQPLLIARDQLAILGSDFAFSQVFRFESDKGILEPLQELGPPALVAPRAFAQVTVAGRRF 515

  Fly   476 VLECDADGNPLPTIDWQ 492
            :......|   ||..:|
Mouse   516 LFAACFKG---PTQIYQ 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064	23/113 (20%)
		leucine-rich repeat	54..77	CDD:275380	6/26 (23%)
		LRR_8	55..112	CDD:290566	13/60 (22%)
		leucine-rich repeat	78..101	CDD:275380	6/22 (27%)
		leucine-rich repeat	102..125	CDD:275380	1/22 (5%)
		LRR_8	124..184	CDD:290566	18/59 (31%)
		leucine-rich repeat	126..149	CDD:275380	5/22 (23%)
		LRR_4	148..185	CDD:289563	13/36 (36%)
		leucine-rich repeat	150..173	CDD:275380	9/22 (41%)
		Ig	240..325	CDD:299845	18/95 (19%)
		IG_like	242..325	CDD:214653	18/93 (19%)
		I-set	366..450	CDD:254352	27/119 (23%)
		Ig	384..451	CDD:143165	21/101 (21%)
		I-set	458..546	CDD:254352	11/37 (30%)
		Ig	472..536	CDD:299845	6/21 (29%)
		I-set	553..644	CDD:254352
		Ig	570..643	CDD:299845
		An_peroxidase	777..1317	CDD:281139
		peroxidasin_like	898..1338	CDD:188658
		VWC	1465..1523	CDD:278520
Lgi4	NP_653139.2	LRR 1	53..74		5/20 (25%)
		leucine-rich repeat	54..77	CDD:275378	5/22 (23%)
		LRR_8	76..136	CDD:290566	16/83 (19%)
		LRR 2	77..98		4/20 (20%)
		leucine-rich repeat	78..101	CDD:275378	6/22 (27%)
		LRR 3	101..122		5/44 (11%)
		LRR_4	102..140	CDD:289563	11/61 (18%)
		leucine-rich repeat	102..125	CDD:275378	6/46 (13%)
		LRR 4	125..146		8/20 (40%)
		leucine-rich repeat	126..149	CDD:275378	9/22 (41%)
		leucine-rich repeat	150..162	CDD:275378	4/11 (36%)
		LRRCT	158..206	CDD:214507	10/55 (18%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	210..252		14/64 (22%)
		EPTP	<220..251	CDD:281697	10/53 (19%)
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	256..298		9/48 (19%)
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	302..349		14/52 (27%)
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	351..394		12/45 (27%)
		EPTP	351..392	CDD:281697	12/43 (28%)
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	396..439		3/42 (7%)
		EPTP	396..438	CDD:281697	3/41 (7%)
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	441..483		9/41 (22%)
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	487..532		14/46 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910