DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxn and IGSF9B

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	481	Identity:	113/481 - (23%)
Similarity:	189/481 - (39%)	Gaps:	83/481 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 MLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVELSCE----VTGLPRPQIT-WM------ 270
            ::..:|.::.|.|..: .:|:|:.|      .|||.|.|.|:    |||.|.|.:. |.
Human    12 VIGTRGLAAEGAHGLR-EEPEFVTA------RAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPI 69

  Fly   271 -------HNTQELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQPVRLVVNGG 328
                   :....:..|...:|.:....||.:....:.|.|.|:|              ::::
Human    70 PIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYEC--------------KVLM--- 117

  Fly   329 NHPLDSPIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQPHDQIVALHGSGHVLLDCAASGW 393
               ||...|...|..|...            .:.:||.||..|...|.|..| |.:.:.|.|.|.
Human   118 ---LDQQYDTFHNGSWVHL------------TINAPPTFTETPPQYIEAKEG-GSITMTCTAFGN 166

  Fly   394 PQPDIQWFVNGRQLLQSTPSLQLQANGSLILLQPNQLSAGTYRCEARNSLGSVQATARIELKELP 458
            |:|.:.|...| .||.::...|: ::|||.:...::...|.|.|.|.:..|....|..:.::..|
Human   167 PKPIVTWLKEG-TLLGASGKYQV-SDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPP 229

  Fly   459 EILTAPQSQTIKLGKAFVLECDAD---GNPLPTIDWQLNGVPLPGNTPDLQLENE---NTELVVG 517
            .|::.|::.|:.:.:..:|.|.|:   ||...|..||...|....   ||:|...   :..|::.
Human   230 FIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQN---DLKLRVRILIDGTLIIF 291

  Fly   518 AARQEHAGVYRCTAHNENGET-SVEATIKVERSQSPPQLAIEPSNLVAITGTTIELPCQADQPED 581
            ..:.|.:|.|.|...|..|.: |..|.:.|   |.|.::...|..:....|....:.|..|....
Human   292 RVKPEDSGKYTCVPSNSLGRSPSASAYLTV---QYPARVLNMPPVIYVPVGIHGYIRCPVDAEPP 353

  Fly   582 GLQISWRHDGRLIDPNVQLAEKYQISGAGSLFVKNVTIPDGGRYECQLKNQFGR--ASASALVTI 644
            ...:.|..|||.:.....|.  :.:...||:.::..|....|.|.|...|..|.  .||.|.:.:
Human   354 ATVVKWNKDGRPLQVEKNLG--WTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVL 416

  Fly   645 RN--NVDLAPGDRYVRIAFAEAAKEI 668
            ::  ...:.||..|.:    ||.:|:
Human   417 KDPPYFTVLPGWEYRQ----EAGREL 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064
		leucine-rich repeat	54..77	CDD:275380
		LRR_8	55..112	CDD:290566
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380
		LRR_8	124..184	CDD:290566
		leucine-rich repeat	126..149	CDD:275380
		LRR_4	148..185	CDD:289563
		leucine-rich repeat	150..173	CDD:275380
		Ig	240..325	CDD:299845	21/102 (21%)
		IG_like	242..325	CDD:214653	20/100 (20%)
		I-set	366..450	CDD:254352	25/83 (30%)
		Ig	384..451	CDD:143165	19/66 (29%)
		I-set	458..546	CDD:254352	25/94 (27%)
		Ig	472..536	CDD:299845	18/69 (26%)
		I-set	553..644	CDD:254352	20/92 (22%)
		Ig	570..643	CDD:299845	18/74 (24%)
		An_peroxidase	777..1317	CDD:281139
		peroxidasin_like	898..1338	CDD:188658
		VWC	1465..1523	CDD:278520
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	23/104 (22%)
		Ig	41..115	CDD:143165	17/87 (20%)
		I-set	139..225	CDD:254352	27/88 (31%)
		IGc2	153..210	CDD:197706	18/59 (31%)
		I-set	229..321	CDD:254352	25/94 (27%)
		Ig	235..321	CDD:299845	23/88 (26%)
		IG_like	331..414	CDD:214653	20/84 (24%)
		Ig	<353..414	CDD:299845	16/62 (26%)
		IG_like	426..505	CDD:214653	6/17 (35%)
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810