DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pxn and Tpo

DIOPT Version :9

Sequence 1:NP_523891.2 Gene:Pxn / 38326 FlyBaseID:FBgn0011828 Length:1527 Species:Drosophila melanogaster
Sequence 2:XP_011242158.1 Gene:Tpo / 22018 MGIID:98813 Length:915 Species:Mus musculus


Alignment Length:777 Identity:300/777 - (38%)
Similarity:432/777 - (55%) Gaps:79/777 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   668 IDLAINNTLDMLFSNRSDKAPPNYGELLRVFRFPTGEARQLARAAEIYERTLVNIRKHVQEGDNL 732
            :|.|:.||:......|...:|   .:||..|:.|...:..::|||||.|.::            .
Mouse    50 VDHAVYNTMKRNLKKREVLSP---AQLLSFFKLPESTSGAISRAAEIMETSI------------Q 99

  Fly   733 TMKSEEYEF-RDLLSREHLHLVAELSGCMEHREMPNCTDMCFHSRYRSIDGTCNNLQHPTWGASL 796
            .||.|:.:| .|.||.:.|..:|.||||:.....|.|.|.|..::||.|.|.|||..||.||||.
Mouse   100 VMKREQSQFSTDALSADILGTIANLSGCLPFMLPPRCPDTCLANKYRPITGACNNRDHPRWGASN 164

  Fly   797 TAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARLVSTSL--VATKEITPDARITHMVMQWGQ 859
            ||..|..||:||:|||.|.||....||.|...|..|.|:..|  |:.:.:|.|.:.:..:..|||
Mouse   165 TALARWLPPVYEDGFSQPKGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTEDDQYSDFLPVWGQ 229

  Fly   860 FLDHDLDHAIPSVSSES-WDGIDCKKSCEMAPPCYPIEVPPNDPRVRNRRCIDVVRSSAICGSGM 923
            ::|||:.....|.|:.: |.|:||:.:||...||:||::|.|..  ....|:...||||.||:|.
Mouse   230 YIDHDIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPSNSS--GTTACLPFYRSSAACGTGD 292

  Fly   924 TSLFF---DSVQHREQINQLTSYIDASQVYGYSTAFAQELRNLTSQEGLLRVG-VHFPRQKDMLP 984
            ....|   .:...|:|:|.|||::|||.|||.|....::|||.:|..|||||. :|....:..||
Mouse   293 QGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDAGRAYLP 357

  Fly   985 FA----APQDGMDCRRNLDENTMSCFVSGDIRVNEQVGLLAMHTIWMREHNRIASKLKQINSHWD 1045
            ||    ||:.|..     ..|...||::||.|.:|...|.|:||:|:|||||:||..|.||.||.
Mouse   358 FATAACAPEPGTP-----RTNRTPCFLAGDGRASEVPALAAVHTLWLREHNRLASAFKAINKHWS 417

  Fly  1046 GDTLYQEARKIVGAQMQHITFKQWLPLIIG-ESGMEMMGEYQGYNPQLNPSIANEFATAALRFGH 1109
            .:|.||||||:|||..|.||.:.::|.|:| ::..:.:|.|:||||.:||:::|.|:|||.||||
Mouse   418 ANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQYVGPYEGYNPTVNPTVSNIFSTAAFRFGH 482

  Fly  1110 TIINPILHRLNETFQ---PIPQGHLLLHKAFFAPWRLAYEGGVDPLMRGFLAVPAKLKTPDQNLN 1171
            ..::|::.|||..||   .:|:  |.|...||.||||..|||:||::||.||..|||:...|.:|
Mouse   483 ATVHPLVRRLNTDFQEHTELPR--LQLRDVFFRPWRLIQEGGLDPIVRGLLARAAKLQVQGQLMN 545

  Fly  1172 TELTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYRKLCNLTVAQDFEDLAGEISSAEIRQKM 1236
            .||||:||..::...||||::|:|||||||:|.||.:|:.|.|:..:...:|...|::..:..|:
Mouse   546 EELTERLFVLSNVGTLDLASLNLQRGRDHGLPDYNEWREFCGLSRLETPAELNKAIANRSMVNKI 610

  Fly  1237 KELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLRDGDRLYYENPGVFSPEQLTQIK 1301
            .:||.|.||:||||||:.|..:.|.:.||||.|::.:|.:.||||||.::||..||:..|..:::
Mouse   611 MDLYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENTNVFTDAQRQELE 675

  Fly  1302 QANFGRVLCDVGDNFDQVTENVFILAKHQGGYKKCEDIIGINLYLWQEC----GRCNSPPAI--- 1359
            :.:..||:|| .....:|..:.|.:.|....::.||||..::|.||:|.    .:|..|..:   
Mouse   676 KHSLPRVICD-NTGLTRVPVDAFRIGKFPQDFESCEDIPSMDLELWRETFPQDDKCVFPEEVDNG 739

  Fly  1360 -----------------FDSYIPQTYTKRSNRQKRDLGKENDEVATAESYDSPLESLYDVNE 1404
                             |..|..|             |:| ....|.:.:||......||||
Mouse   740 NFVHCEESGKLVLVYSCFHGYKLQ-------------GQE-QVTCTQKGWDSEPPVCKDVNE 787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PxnNP_523891.2 LRR_RI 51..>161 CDD:238064
leucine-rich repeat 54..77 CDD:275380
LRR_8 55..112 CDD:290566
leucine-rich repeat 78..101 CDD:275380
leucine-rich repeat 102..125 CDD:275380
LRR_8 124..184 CDD:290566
leucine-rich repeat 126..149 CDD:275380
LRR_4 148..185 CDD:289563
leucine-rich repeat 150..173 CDD:275380
Ig 240..325 CDD:299845
IG_like 242..325 CDD:214653
I-set 366..450 CDD:254352
Ig 384..451 CDD:143165
I-set 458..546 CDD:254352
Ig 472..536 CDD:299845
I-set 553..644 CDD:254352
Ig 570..643 CDD:299845
An_peroxidase 777..1317 CDD:281139 242/554 (44%)
peroxidasin_like 898..1338 CDD:188658 192/451 (43%)
VWC 1465..1523 CDD:278520
TpoXP_011242158.1 thyroid_peroxidase 161..722 CDD:188657 242/570 (42%)
CCP 730..783 CDD:153056 10/66 (15%)
EGF_CA 784..826 CDD:311536 4/4 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2408
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D276568at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11475
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2739
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.950

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