DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxn and Lrrtm3

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	NP_848793.1	Gene:	Lrrtm3 / 216028	MGIID:	2389177	Length:	582	Species:	Mus musculus

Alignment Length:	671	Identity:	147/671 - (21%)
Similarity:	244/671 - (36%)	Gaps:	193/671 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLLLAGGVQSVYCPAGCTCLERTVRCIRAKLSAVP-KLPQDTQTLDLRFNHIEELPANAFSGLA 76
            ||.:|:...:.  ||.||.|..:.|.|...||..:| .:......|.||:|.:::|..|.|.||.
Mouse    23 LLTMLSSAERG--CPKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLN 85

  Fly    77 QLTTLFLNDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPRLEAIFLENNDIWQLPA 141
            |||.|:|:.|.::.:.:.|.||:..|:.:.|::||:|......|:.:..|..:.|..|.:..|.:
Mouse    86 QLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGS 150

  Fly   142 GLFDNLPRLNRLIMYNNKLTQLPVD-------------GFNRLNN-----------LKRLRLDGN 182
            ..|..|.:|..|.:.:|.|..:||.             |:||:.:           ||.|.|:.|
Mouse   151 EQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHN 215

  Fly   183 AID-CNCGVY-------SLWRRWH-LDVQRQLVSISLTCAAPQMLQNQG-----FSSLGEHHFKC 233
            ... .|..::       :|:.:|: :.|..|  ::|.|.::.|.|...|     ||  |...|:|
Mouse   216 QFSKLNLALFPRLVSLQNLYMQWNKISVIGQ--TMSWTWSSLQRLDLSGNEIEAFS--GPSVFQC 276

  Fly   234 AKPQFLVAPQDAQVAAGEQVELSCEVTGLPRPQITWMHNTQELGLEEQAQA----EILPSGSLLI 294
                                                :.|.|.|.|:.....    |||.|   .|
Mouse   277 ------------------------------------VPNLQRLNLDSNKLTFIGQEILDS---WI 302

  Fly   295 RSADTSDMG-IYQCIARN---------------EMGALRSQPVRLVVNGGNHPLDSPIDARSNQV 343
            ...|.|..| |::| :||               |...:.:.|..|  .|.|     .|||..|..
Mouse   303 SLNDISLAGNIWEC-SRNICSLVNWLRSFKGLRENTIICASPKEL--QGVN-----VIDAVKNYS 359

  Fly   344 WADAGTPMHG---ATPLPSP-----LPSPPHFTHQPHDQIVALHGSGHVLLDCAASGWPQPDIQW 400
            .....|....   |..||.|     ||.|.|.:..|....|.           |....|:.|:..
Mouse   360 ICGKSTTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVG-----------ATEPSPETDVDT 413

  Fly   401 -FVNGRQLLQSTPSLQLQANGSLILLQPNQLS-----AGTYRCEARNSLGSVQATARIELKELPE 459
             .::..:::..:.:|.|..   |::|....:|     |...:.:.|:.:...:...|..||::
Mouse   414 EHISFHKIIAGSVALFLSV---LVILLVMYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLKQM-- 473

  Fly   460 ILTAPQSQTIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQLENENTELVVGAARQEHA 524
               .|.:|..                  .:|::      |.||       |.:|:::.
Mouse   474 ---TPGTQEF------------------YVDYK------PTNT-------ETSEMLLN------- 497

  Fly   525 GVYRCTAHNENGETSVEATIKVERS----QSPPQLAIEPSNLVAITGTTIELPCQADQPEDGLQI 585
            |...|| ::::|....|..:.:..|    ...|.::....:...::..:.|...|.|..|..|:.
Mouse   498 GTGPCT-YSKSGSRECEIPLSMNVSTFLAYDQPTISYCGVHHELLSHKSFETNAQEDTMESHLET 561

  Fly   586 -----SWRHDGRLIDPNVQLA 601
                 :....||:.|...|||
Mouse   562 ELDLSTITSAGRISDHKPQLA 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064	33/109 (30%)
		leucine-rich repeat	54..77	CDD:275380	9/22 (41%)
		LRR_8	55..112	CDD:290566	21/56 (38%)
		leucine-rich repeat	78..101	CDD:275380	8/22 (36%)
		leucine-rich repeat	102..125	CDD:275380	6/22 (27%)
		LRR_8	124..184	CDD:290566	20/83 (24%)
		leucine-rich repeat	126..149	CDD:275380	6/22 (27%)
		LRR_4	148..185	CDD:289563	14/60 (23%)
		leucine-rich repeat	150..173	CDD:275380	9/35 (26%)
		Ig	240..325	CDD:299845	19/104 (18%)
		IG_like	242..325	CDD:214653	19/102 (19%)
		I-set	366..450	CDD:254352	13/89 (15%)
		Ig	384..451	CDD:143165	10/72 (14%)
		I-set	458..546	CDD:254352	13/87 (15%)
		Ig	472..536	CDD:299845	9/63 (14%)
		I-set	553..644	CDD:254352	12/54 (22%)
		Ig	570..643	CDD:299845	11/37 (30%)
		An_peroxidase	777..1317	CDD:281139
		peroxidasin_like	898..1338	CDD:188658
		VWC	1465..1523	CDD:278520
Lrrtm3	NP_848793.1	LRRNT	33..61	CDD:214470	10/29 (34%)
		LRR 1	63..83		7/19 (37%)
		leucine-rich repeat	66..86	CDD:275380	9/19 (47%)
		LRR_RI	<81..300	CDD:238064	60/258 (23%)
		LRR_8	86..145	CDD:290566	18/58 (31%)
		LRR 2	86..107		7/20 (35%)
		leucine-rich repeat	87..110	CDD:275380	8/22 (36%)
		LRR 3	110..131		6/20 (30%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		LRR_8	133..193	CDD:290566	14/59 (24%)
		LRR 4	134..155		5/20 (25%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		LRR 5	158..179		6/20 (30%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		LRR_8	181..241	CDD:290566	11/59 (19%)
		LRR 6	182..203		3/20 (15%)
		leucine-rich repeat	183..206	CDD:275380	3/22 (14%)
		LRR 7	206..226		6/19 (32%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		LRR_8	230..290	CDD:290566	18/99 (18%)
		LRR 8	230..251		5/22 (23%)
		leucine-rich repeat	231..254	CDD:275380	6/24 (25%)
		LRR 9	254..275		6/22 (27%)
		leucine-rich repeat	255..279	CDD:275380	8/61 (13%)
		LRR 10	279..300		7/20 (35%)
		leucine-rich repeat	280..300	CDD:275380	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..410		9/42 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910