DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pxn and pxn-2

DIOPT Version :9

Sequence 1:NP_523891.2 Gene:Pxn / 38326 FlyBaseID:FBgn0011828 Length:1527 Species:Drosophila melanogaster
Sequence 2:NP_509834.1 Gene:pxn-2 / 181288 WormBaseID:WBGene00004257 Length:1328 Species:Caenorhabditis elegans


Alignment Length:1523 Identity:497/1523 - (32%)
Similarity:740/1523 - (48%) Gaps:251/1523 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 LLLAGGVQSVYCPAGCTCLERTVRCIRAKLSAVP-KLPQDTQTLDLRFNHIEELPANAFSGLAQL 78
            |||.|...|..||:.|.|....|.|....|:|:| .:|..|..|....|.:..|..:.|..|..|
 Worm     6 LLLIGISLSTACPSECRCAGLDVHCEGKNLTAIPGHIPIATTNLYFSNNLLNSLSKSNFQALPNL 70

  Fly    79 TTLFLNDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPR-LEAIFLENNDIWQLPAG 142
            ..|.|::|.:..:::..|:....|:::.|:.|::..:|.  ....|. |.::.|.:|:|.:|...
 Worm    71 QYLDLSNNSIRDIEETLLDSFPGLKYLDLSWNKIRYVPK--LSTAPNALVSLNLVHNEISRLDND 133

  Fly   143 LFDNLPRLNRLIMYNNKLTQLPVDGFN--RLNNLKRLRLDGNAIDCNCGVY-------SLWRRWH 198
            |..:.|.:...::..|::..||.|.||  .:..||.:::.||...|:|.:.       ||:..  
 Worm   134 LVSHSPYMQTFLIQRNRIQSLPHDFFNSRMVPTLKTVKMAGNPWSCDCRMVNVKQFADSLFAH-- 196

  Fly   199 LDVQRQLVSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVELSC---EVT 260
               ..|.:.|...|..|:.|:|..|.:|...:.:|.||::      ::...| ..::||   |:.
 Worm   197 ---SNQNIFIVGKCFFPKGLRNYVFRNLSIENLECEKPEY------SKTDDG-MFKMSCPNNEME 251

  Fly   261 GLPRPQITWMHNTQELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQPVRLVV 325
            |.....| ::.|.:|  ....|.......||||.....|.:   |||....:..::..|. ::..
 Worm   252 GYHYDSI-FLENNKE--ARHTAHFARDKDGSLLSNGQFTRN---YQCAFYRQKQSIHMQK-KMQA 309

  Fly   326 NGGNHPLDSPIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQ---PHDQIVALHGSGHVL-L 386
            :....|   ||...:.:....:.......|.....:.:.|....:   .|.|:......|..| |
 Worm   310 SSSTEP---PITTTTMEPMTTSTMDSMDTTESVVTMTTMPEIDTKIVFEHKQLDTTSRDGETLEL 371

  Fly   387 DCAASGWPQPDIQWFVNGRQLLQSTPSLQLQANGSLILLQP-NQLSAGTYRCEARNSLGSVQATA 450
            .|.|||.|.|.|.|....::|.:|... :|..|||::.:.| .....|.|.|.|.|...|.....
 Worm   372 KCEASGEPTPTITWLFEKQKLTESRKH-KLTKNGSVLKIFPFLNTDIGQYECVASNGEESKSHIF 435

  Fly   451 RIELK--ELPEILTAPQSQTIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQLENENTE 513
            .:.||  |.|.|:.||......:|:...|.|:|.|.|:|.:.|...|:.:|.......:.:.|.|
 Worm   436 SVSLKESEQPVIIDAPMDTNATIGQQVTLRCNAKGFPVPDVVWLFEGIRIPRRNTRYTISDNNIE 500

  Fly   514 LVVGAARQEHAGVYRCTAHNENGETSVEATIKVERSQSPPQLAIEPSNLVAITGTTIELPCQADQ 578
            |.:....:..:||:.|.|.|..|.                  |:..:||:.              
 Worm   501 LTIEKVTRHDSGVFTCQAVNSVGS------------------AVATANLLV-------------- 533

  Fly   579 PEDGLQISWRHDGRLIDPNVQLAEKYQISGAGSLFVKNVTIPDGGRYECQLKNQFGRASASALVT 643
               |.:::.:.|..|.|..::...|                                        
 Worm   534 ---GAELTEKVDKLLDDSTIEKIAK---------------------------------------- 555

  Fly   644 IRNNVDLAPGDRYVRIAFAEAAKEIDLAINNTLDMLFSNRSDK-APPNYGELLRVFRFPTGEAR- 706
                               ||.::::.|:::|.|   ..|.|| ..||  :|.::|:|.....: 
 Worm   556 -------------------EAKQKVEKALSSTKD---QQRMDKIESPN--DLSKLFKFAINLKKV 596

  Fly   707 QLARAAEIYERTLVNIRKHVQEG--DNLTMKSEEYEFRDLLSREHLHLVAELSGCMEHREMPNCT 769
            .|.:|.||||.::..::.|:..|  ....|.|....:..:|...::..:.|.|||...:...:|.
 Worm   597 DLGKAREIYEESIRLVQMHIDNGLAFESAMISPNVSYEAVLPVSYVQTLMEKSGCQTGQFAESCE 661

  Fly   770 DMCFHSRYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARLV 834
            |.||.|:|||.||.|||.:||.||.|..||.||.||.|||||:.||||.||..|:|:..|:||.|
 Worm   662 DHCFFSKYRSYDGQCNNHEHPWWGVSEMAFMRLLPPRYENGFNTPVGWEKGKRYNGYEVPNARKV 726

  Fly   835 STSLVATKEITPDARITHMVMQWGQFLDHDLDHAIPSVSSESW-DGIDCKKSCEMAPPCYPIEVP 898
            |..|:.|.|.||.:.::.|.||||||:||||....|:::..|: :|..|.::||.|.||:.|::.
 Worm   727 SRVLIGTDETTPHSHLSAMTMQWGQFIDHDLTLTAPALTRHSYKEGAFCNRTCENADPCFNIQLE 791

  Fly   899 PNDPRV-----RNRRCIDVVRSSAICGSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTAFAQ 958
            .:||::     :...|::..|:.|.||||.||..|..|.:|:|:|.||||:|||.:||.|...|.
 Worm   792 ADDPKLHTGLYQKHPCMEFERNGAACGSGETSPIFQRVTYRDQLNLLTSYLDASGIYGNSEEQAL 856

  Fly   959 ELRNLTSQEGLLRVGVHFPRQKDMLPFAAPQDGMDCRRNLD-ENTMSCFVSGDIRVNEQVGLLAM 1022
            |||:|.|..||||..:.....|..:||....| ||||||.. ||.:.||::||:|.|||:||::|
 Worm   857 ELRDLYSDHGLLRFDIVSGANKPYMPFEKDSD-MDCRRNFSRENPIKCFLAGDVRANEQLGLMSM 920

  Fly  1023 HTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGME-MMGEYQ 1086
            |||::||||||||:|.::|.:|||:|::||.||::||.:||||:..|||.|:|::... ::|||:
 Worm   921 HTIFLREHNRIASRLLEVNENWDGETIFQETRKLIGAMLQHITYNAWLPKILGKATYNTIIGEYK 985

  Fly  1087 GYNPQLNPSIANEFATAALRFGHTIINPILHRLNETFQPIPQGHLLLHKAFFAPWRLAYEGGVDP 1151
            ||||.:||:||||||||||||.||:||..|.|.::.|:...||||.||.|||||.||..||||||
 Worm   986 GYNPDVNPTIANEFATAALRFAHTLINTHLFRFDKDFKETKQGHLPLHNAFFAPERLVSEGGVDP 1050

  Fly  1152 LMRGFLAVPAKLKTPDQNLNTELTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYRKLCNLTV 1216
            |:||..|.|.|:..|||.||.|||||||...|.|||||||:|||||||||:|.:..|||.|||||
 Worm  1051 LLRGLFAAPIKMPRPDQVLNKELTEKLFNRFHEVALDLAALNIQRGRDHGLPSWTEYRKFCNLTV 1115

  Fly  1217 AQDFEDLAGEISSAEIRQKMKELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLRDG 1281
            .:.:.|:...:.:..:..|::.|||..:|:|:|:||:.|.:.....:||...|::.:||:|||||
 Worm  1116 PKTWSDMKNIVQNDTVISKLQSLYGVTENIDLWVGGVTEKRTADALMGPTLACIIADQFKRLRDG 1180

  Fly  1282 DRLYYENPGVFSPEQLTQIKQANFGRVLCDVGDNFDQVTENVFILAKHQGG----YKKCEDIIGI 1342
            ||.:|||..:||..||.|||:....:::|..||:.|::..::|:   :.|.    |:.||.:..|
 Worm  1181 DRFWYENEEMFSKAQLRQIKKVTLSKIICTNGDDIDRIQRDIFV---YHGNSTQFYEPCESLPEI 1242

  Fly  1343 NLYLWQEC--GRCNSPPAIFDSYIPQTYTKRSNRQKRDLGKENDEVATAESYDSPLESLYDVNEE 1405
            ||.:|..|  ..|:|               .|...:..:|  .||.|                  
 Worm  1243 NLNMWTTCCDAMCSS---------------SSTLARNAIG--GDEKA------------------ 1272

  Fly  1406 RVSGLEELIGSFQKELKKLHKKLRKLEDSCNSADSEPVAQVVQLAAAPPQLVSKPKRSHCVDDKG 1470
                         |..|:.|...:|   ||:                               |||
 Worm  1273 -------------KRRKRRHHHSKK---SCH-------------------------------DKG 1290

  Fly  1471 TTRLNNEVW--SPDVCTKCNCFHGQVNC 1496
            ..|.:.:.|  |.|:|.:|.|..|:|.|
 Worm  1291 KRRKSGDRWNHSNDICVECMCHDGEVWC 1318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PxnNP_523891.2 LRR_RI 51..>161 CDD:238064 25/110 (23%)
leucine-rich repeat 54..77 CDD:275380 6/22 (27%)
LRR_8 55..112 CDD:290566 13/56 (23%)
leucine-rich repeat 78..101 CDD:275380 5/22 (23%)
leucine-rich repeat 102..125 CDD:275380 4/22 (18%)
LRR_8 124..184 CDD:290566 18/62 (29%)
leucine-rich repeat 126..149 CDD:275380 6/22 (27%)
LRR_4 148..185 CDD:289563 11/38 (29%)
leucine-rich repeat 150..173 CDD:275380 6/24 (25%)
Ig 240..325 CDD:299845 18/87 (21%)
IG_like 242..325 CDD:214653 18/85 (21%)
I-set 366..450 CDD:254352 26/88 (30%)
Ig 384..451 CDD:143165 23/68 (34%)
I-set 458..546 CDD:254352 23/87 (26%)
Ig 472..536 CDD:299845 18/63 (29%)
I-set 553..644 CDD:254352 8/90 (9%)
Ig 570..643 CDD:299845 5/72 (7%)
An_peroxidase 777..1317 CDD:281139 281/547 (51%)
peroxidasin_like 898..1338 CDD:188658 223/450 (50%)
VWC 1465..1523 CDD:278520 13/34 (38%)
pxn-2NP_509834.1 LRRNT 16..43 CDD:396168 9/26 (35%)
leucine-rich repeat 28..44 CDD:275380 5/15 (33%)
PRK15370 <35..>155 CDD:185268 28/121 (23%)
leucine-rich repeat 46..69 CDD:275378 6/22 (27%)
LRR_8 47..104 CDD:404697 13/56 (23%)
leucine-rich repeat 70..93 CDD:275378 5/22 (23%)
leucine-rich repeat 94..116 CDD:275378 5/23 (22%)
leucine-rich repeat 117..140 CDD:275378 6/22 (27%)
leucine-rich repeat 141..154 CDD:275378 1/12 (8%)
Ig 346..432 CDD:416386 27/86 (31%)
Ig strand B 369..373 CDD:409353 2/3 (67%)
Ig strand C 382..386 CDD:409353 1/3 (33%)
Ig strand E 405..410 CDD:409353 1/4 (25%)
Ig strand F 419..424 CDD:409353 2/4 (50%)
I-set 445..533 CDD:400151 26/105 (25%)
Ig strand A' 453..457 CDD:409353 0/3 (0%)
Ig strand B 460..469 CDD:409353 2/8 (25%)
Ig strand C 475..480 CDD:409353 1/4 (25%)
Ig strand C' 483..486 CDD:409353 0/2 (0%)
Ig strand D 491..496 CDD:409353 0/4 (0%)
Ig strand E 497..505 CDD:409353 3/7 (43%)
Ig strand F 512..520 CDD:409353 4/7 (57%)
Ig strand G 523..533 CDD:409353 4/27 (15%)
peroxidasin_like 798..1238 CDD:188658 221/443 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160167943
Domainoid 1 1.000 610 1.000 Domainoid score I90
eggNOG 1 0.900 - - E1_KOG2408
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H33907
Inparanoid 1 1.050 727 1.000 Inparanoid score I318
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46064
OrthoDB 1 1.010 - - D276568at2759
OrthoFinder 1 1.000 - - FOG0000202
OrthoInspector 1 1.000 - - otm14274
orthoMCL 1 0.900 - - OOG6_105829
Panther 1 1.100 - - O PTHR11475
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2739
SonicParanoid 1 1.000 - - X2950
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.800

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