DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxn and skpo-3

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	NP_495511.1	Gene:	skpo-3 / 174191	WormBaseID:	WBGene00017968	Length:	1000	Species:	Caenorhabditis elegans

Alignment Length:	648	Identity:	236/648 - (36%)
Similarity:	358/648 - (55%)	Gaps:	52/648 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 ARAAEIYERTLVNIRKHVQEGDNLTMKSEEYEFRDLLSREHLHLVAELSGCMEHREMPNC-TDMC 772
            ||..:|....:|......:|  .|.:.:|:...|..:..:.:......:.|....:..:| .::|
Worm   397 ARCRDIINDPIVAAEDMWRE--RLVVATEDNTRRQTVDLDQVIRSNTANACTPRLDEADCEANIC 459

  Fly   773 FHSRYRSIDGTCNNLQ-HPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARLVST 836
            :::.:|::||||||:: .|..|||...:.||.|.||:|..|.||    |.|:: .|:||.|.::.
Worm   460 YNAMFRTLDGTCNNMKGEPLRGASYRPYTRLLPTIYDNEVSEPV----GSLFT-DARPSPREITR 519

  Fly   837 SLVATKEITPDARITHMVMQWGQFLDHDLDHAIPSVSSESWDGIDCKKSCEMAPPC--YPIEVPP 899
            .|.:::..........::||:|||:.||:.......||:      |.....:...|  .||....
Worm   520 RLTSSQASVESPDYNALIMQFGQFISHDMAKTTLVPSSK------CNVCQNITSRCMSVPITFDD 578

  Fly   900 NDPRVRNRRCIDVVRSSAICGSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTAFAQELRNLT 964
            ::...|..:||.|.|||.|||||       :::.|:|:|:.|.|||||.:||.|...:::.|:
Worm   579 SNANFRQAQCIRVSRSSPICGSG-------NLKPRQQLNENTGYIDASPIYGSSVHDSKKFRD-- 634

  Fly   965 SQEGLLRVGVHFPRQKDMLPFAAPQDGMDCRRNLDENTMSC---FVSGDIRVNEQVGLLAMHTIW 1026
            ...|.|::.:.  ..|..|||    |...||     |...|   |.:||.|||..|||.|.|||:
Worm   635 GNSGFLKLPMF--NGKAFLPF----DQNKCR-----NRGQCSVIFTAGDSRVNLFVGLSAWHTIF 688

  Fly  1027 MREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEMMGEYQGYNPQ 1091
            ..||||:.:..|::|.||||:.|||||||::|||:|.|.:::|||.::|.|...::|:|:||:..
Worm   689 TEEHNRLVTAFKRLNPHWDGERLYQEARKMIGAQVQAIVYREWLPKVLGASFATVVGDYRGYDSD 753

  Fly  1092 LNPSIANEFATAALRFGHTIINPILHRLNETFQPIPQGHLLLHKAFFAPWRLAYEGGVDPLMRGF 1156
            ::.::||||.:||.||||.:|.....||:.:|:.|..|.|...|.......|..|||||||:||.
Worm   754 VDSTVANEFTSAAFRFGHGMIQEFYQRLDNSFRNISFGALPFQKGTLHSDVLVNEGGVDPLIRGM 818

  Fly  1157 LAVPAKLKTPDQNLNTELTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYRKLCNLTVAQDFE 1221
            .:  ..:|.| |.:.|.:||.:|.:.     ||:.||||||||||.|.|..||:||.:..|.:||
Worm   819 FS--QNVKRP-QRVTTTVTENMFGST-----DLSTINIQRGRDHGHPAYVKYRELCGMGTAFNFE 875

  Fly  1222 DLAGEISSAEIRQKMKELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLRDGDRLYY 1286
            .|:.||.:...|.|::|:||..|.:|:|:|.:|||.:..|.|||...|::..||:|.|||||.||
Worm   876 HLSREILNTGTRNKLQEIYGSVDKIDLWVGALLEDPIIRGLVGPTVACIIGPQFKRTRDGDRFYY 940

  Fly  1287 ENPGVFSPEQLTQIKQANFGRVLCDVGDNFDQVTENVFILAKHQGGYKKCEDIIGINLYLWQE 1349
            |||||||..||.:|::::..|::||..:....:....|    ..|....|..|..::|..|::
Worm   941 ENPGVFSRRQLVEIRKSSLSRIICDNTNTISTIPREAF----RVGHMVPCSQIPSMDLNQWRD 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064
		leucine-rich repeat	54..77	CDD:275380
		LRR_8	55..112	CDD:290566
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380
		LRR_8	124..184	CDD:290566
		leucine-rich repeat	126..149	CDD:275380
		LRR_4	148..185	CDD:289563
		leucine-rich repeat	150..173	CDD:275380
		Ig	240..325	CDD:299845
		IG_like	242..325	CDD:214653
		I-set	366..450	CDD:254352
		Ig	384..451	CDD:143165
		I-set	458..546	CDD:254352
		Ig	472..536	CDD:299845
		I-set	553..644	CDD:254352
		Ig	570..643	CDD:299845
		An_peroxidase	777..1317	CDD:281139	219/545 (40%)
		peroxidasin_like	898..1338	CDD:188658	182/442 (41%)
		VWC	1465..1523	CDD:278520
skpo-3	NP_495511.1	ShKT	41..75	CDD:214586
skpo-3	NP_495511.1	An_peroxidase	464..978	CDD:376988	219/552 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020