DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxn and AgaP_AGAP001239

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	XP_321915.5	Gene:	AgaP_AGAP001239 / 1281931	VectorBaseID:	AGAP001239	Length:	299	Species:	Anopheles gambiae

Alignment Length:	333	Identity:	72/333 - (21%)
Similarity:	110/333 - (33%)	Gaps:	97/333 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 TIFQRM-PRLEAIFLENNDIWQLPAG--LFDNLPRLNRLIMYNNKLTQLPVDGFNRLNNLKRLRL 179
            |||..: |.|..|..|....|:.|..  .|||          :.|.......|.:.|.:.:...|
Mosquito     4 TIFITLFPVLNIISGEVQSYWEQPFAQPYFDN----------STKREVTATVGQSALLHCRVRNL 58

  Fly   180 DGNAIDCNCGVYSLWRRWHLDVQRQLVSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQD 244
            ...|:.        |.| ..|:....|.| ||....|..|:.......|...:...||    |:|
Mosquito    59 GDRAVS--------WIR-KRDLHILTVGI-LTYTNDQRFQSLHTEGSDEWTLRITSPQ----PRD 109

  Fly   245 A-----QVA-----------------------------AGEQVELSCEVTGLPRPQ--ITWMHNT 273
            :     ||:                             :|..:.|:|.....|.|.  |.|....
Mosquito   110 SGTYECQVSTEPKISQAFRLNVVVSKAKILGNSELFIKSGSDINLTCVALQSPAPPSFIYWYKGG 174

  Fly   274 QELGLEEQAQAEIL-----PSGSLLIRSADTSDMGIYQCIARNEMGALRSQPVRLVVNGGNHPLD 333
            :.:...::....:|     .:..|:|..|..||.|.|.|...:...|   ..|..|:||     :
Mosquito   175 RVVNYSQRGGISVLTERQTKTSKLVIARAMPSDSGNYTCSPSSSDSA---SVVVHVING-----E 231

  Fly   334 SPIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQPH---DQIVA-LHGSGHVLLDCAASGWP 394
            .|            ....||.:...|.|.:...|:|:.|   |:.:| |.||.:::|..|::|
Mosquito   232 QP------------AAMQHGNSSANSVLINNRSFSHRGHGPLDRWLAYLGGSKNLILSLASTG-- 282

  Fly   395 QPDIQWFV 402
               :.|.|
Mosquito   283 ---LCWLV 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064	13/45 (29%)
		leucine-rich repeat	54..77	CDD:275380
		LRR_8	55..112	CDD:290566
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380	3/7 (43%)
		LRR_8	124..184	CDD:290566	13/61 (21%)
		leucine-rich repeat	126..149	CDD:275380	8/24 (33%)
		LRR_4	148..185	CDD:289563	5/36 (14%)
		leucine-rich repeat	150..173	CDD:275380	3/22 (14%)
		Ig	240..325	CDD:299845	22/125 (18%)
		IG_like	242..325	CDD:214653	22/123 (18%)
		I-set	366..450	CDD:254352	13/41 (32%)
		Ig	384..451	CDD:143165	5/19 (26%)
		I-set	458..546	CDD:254352
		Ig	472..536	CDD:299845
		I-set	553..644	CDD:254352
		Ig	570..643	CDD:299845
		An_peroxidase	777..1317	CDD:281139
		peroxidasin_like	898..1338	CDD:188658
		VWC	1465..1523	CDD:278520
AgaP_AGAP001239	XP_321915.5	V-set	37..132	CDD:284989	21/108 (19%)
		IG_like	39..131	CDD:214653	20/105 (19%)
		IG_like	147..>213	CDD:214653	15/65 (23%)
		Ig	152..>213	CDD:143165	14/60 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910