DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxn and TOLL11

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	XP_309461.4	Gene:	TOLL11 / 1270742	VectorBaseID:	AGAP011186	Length:	1360	Species:	Anopheles gambiae

Alignment Length:	240	Identity:	62/240 - (25%)
Similarity:	102/240 - (42%)	Gaps:	48/240 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CPAGCTCLERT------VRCIRAKLSAVP-KLPQDTQTLDLRFNHIEELPANAFSGLAQLTTLFL 83
            ||..|.|...|      |.|..|.||.|| |:|.|...:.|..|::..|.::.|.|..:|.:|:|
Mosquito   777 CPDRCRCYHDTAWESNIVDCGSAGLSLVPAKIPMDATDIYLDGNNLGALGSHVFIGKKKLKSLYL 841

  Fly    84 NDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPRLEAIFLENNDIWQLPAGLFDNLP 148
            |.:.:..|.:....|:.||..::|..|.|.:|....|:::..|:.::|..|.:..:.
Mosquito   842 NGSRIESLNNKTFAGIPALEVLHLEQNGLEQLSGAEFEQLRELKELYLHRNALASIG-------- 898

  Fly   149 RLNRLIMYNNKLTQLPVDGFNRLNNLKRLR--------------------LDGNAIDCNCGVYSL 193
              ||...|...|..|.::.    |.||.:|                    |:|||::|:|.:...
Mosquito   899 --NRSFYYQKSLEVLTIEE----NKLKGVRPWELLPLPSGGPDGAYRSVSLEGNALECSCELLPK 957

  Fly   194 WRRWHLDVQRQLVSISLTCAAPQMLQNQGFSSLGEHHFKCA--KP 236
            ...|   ::|...|......:.:..::...:|.||  |:||  ||
Mosquito   958 LLDW---LERMYRSNGSAAQSEEQTESSEETSWGE--FQCAGGKP 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064	26/109 (24%)
		leucine-rich repeat	54..77	CDD:275380	5/22 (23%)
		LRR_8	55..112	CDD:290566	15/56 (27%)
		leucine-rich repeat	78..101	CDD:275380	6/22 (27%)
		leucine-rich repeat	102..125	CDD:275380	6/22 (27%)
		LRR_8	124..184	CDD:290566	15/79 (19%)
		leucine-rich repeat	126..149	CDD:275380	3/22 (14%)
		LRR_4	148..185	CDD:289563	13/56 (23%)
		leucine-rich repeat	150..173	CDD:275380	5/22 (23%)
		Ig	240..325	CDD:299845
		IG_like	242..325	CDD:214653
		I-set	366..450	CDD:254352
		Ig	384..451	CDD:143165
		I-set	458..546	CDD:254352
		Ig	472..536	CDD:299845
		I-set	553..644	CDD:254352
		Ig	570..643	CDD:299845
		An_peroxidase	777..1317	CDD:281139
		peroxidasin_like	898..1338	CDD:188658
		VWC	1465..1523	CDD:278520
TOLL11	XP_309461.4	LRR_8	115..180	CDD:290566
		leucine-rich repeat	116..139	CDD:275380
		LRR_RI	140..390	CDD:238064
		leucine-rich repeat	140..169	CDD:275380
		LRR_8	168..240	CDD:290566
		leucine-rich repeat	170..193	CDD:275380
		leucine-rich repeat	194..229	CDD:275380
		LRR_8	228..288	CDD:290566
		leucine-rich repeat	230..253	CDD:275380
		leucine-rich repeat	254..277	CDD:275380
		LRR_8	277..336	CDD:290566
		LRR_RI	278..577	CDD:238064
		leucine-rich repeat	278..301	CDD:275380
		leucine-rich repeat	302..325	CDD:275380
		leucine-rich repeat	326..351	CDD:275380
		LRR_8	351..410	CDD:290566
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..399	CDD:275380
		LRR_8	398..458	CDD:290566
		leucine-rich repeat	400..423	CDD:275380
		leucine-rich repeat	424..447	CDD:275380
		LRR_8	471..529	CDD:290566
		leucine-rich repeat	471..494	CDD:275380
		leucine-rich repeat	495..518	CDD:275380
		LRR_8	517..576	CDD:290566
		leucine-rich repeat	519..542	CDD:275380
		leucine-rich repeat	543..563	CDD:275380
		leucine-rich repeat	566..655	CDD:275380
		LRR_8	587..645	CDD:290566
		leucine-rich repeat	613..634	CDD:275380
		leucine-rich repeat	659..687	CDD:275380
		LRRNT	776..813	CDD:214470	15/35 (43%)
		leucine-rich repeat	793..811	CDD:275380	9/17 (53%)
		leucine-rich repeat	812..835	CDD:275380	5/22 (23%)
		LRR_8	834..894	CDD:290566	16/59 (27%)
		LRR_4	834..875	CDD:289563	12/40 (30%)
		leucine-rich repeat	836..859	CDD:275380	6/22 (27%)
		leucine-rich repeat	860..883	CDD:275380	6/22 (27%)
		LRR_8	882..948	CDD:290566	15/79 (19%)
		leucine-rich repeat	884..907	CDD:275380	6/32 (19%)
		leucine-rich repeat	938..950	CDD:275378	4/11 (36%)
		TIR_2	1090..1230	CDD:304906
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910