DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxn and Prelp

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	NP_473418.3	Gene:	Prelp / 116847	MGIID:	2151110	Length:	378	Species:	Mus musculus

Alignment Length:	176	Identity:	55/176 - (31%)
Similarity:	82/176 - (46%)	Gaps:	12/176 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LAGGVQSVY--CPAGCTC---LERTVRCIRAKLSAVPKLPQDTQTLDLRFNHIEELPANAFSGLA 76
            |..|..||:  ||..|.|   ....:.|....|..||.:|.....|.|:.|.|.|||..:|....
Mouse    58 LPPGPPSVFPDCPRECYCPPDFPSALYCDSRNLRRVPVIPPRIHYLYLQNNFITELPLESFQNAT 122

  Fly    77 QLTTLFLNDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPR-LEAIFLENNDIWQLP 140
            .|..:.|::|.:..:....|..|.:|.|:|:..|:|..:|:.    :|| ||.:.|..|.|.::|
Mouse   123 GLRWVNLDNNRIRKVDQRVLGKLPSLAFLYMEKNQLEEVPSA----LPRNLEQLRLSQNLISRIP 183

  Fly   141 AGLFDNLPRLNRLIMYNNKLTQ--LPVDGFNRLNNLKRLRLDGNAI 184
            .|:|..|..|..|.:.:|:|:.  ...|.|..|.||.:|.|..|.:
Mouse   184 PGVFSKLENLLLLDLQHNRLSDGVFKADTFQGLKNLMQLNLAHNIL 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064	34/110 (31%)
		leucine-rich repeat	54..77	CDD:275380	8/22 (36%)
		LRR_8	55..112	CDD:290566	17/56 (30%)
		leucine-rich repeat	78..101	CDD:275380	5/22 (23%)
		leucine-rich repeat	102..125	CDD:275380	6/22 (27%)
		LRR_8	124..184	CDD:290566	23/62 (37%)
		leucine-rich repeat	126..149	CDD:275380	9/22 (41%)
		LRR_4	148..185	CDD:289563	12/39 (31%)
		leucine-rich repeat	150..173	CDD:275380	7/24 (29%)
		Ig	240..325	CDD:299845
		IG_like	242..325	CDD:214653
		I-set	366..450	CDD:254352
		Ig	384..451	CDD:143165
		I-set	458..546	CDD:254352
		Ig	472..536	CDD:299845
		I-set	553..644	CDD:254352
		Ig	570..643	CDD:299845
		An_peroxidase	777..1317	CDD:281139
		peroxidasin_like	898..1338	CDD:188658
		VWC	1465..1523	CDD:278520
Prelp	NP_473418.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..62		1/3 (33%)
		LRRNT	68..103	CDD:214470	9/34 (26%)
		LRR 1	91..110		6/18 (33%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		LRR 2	111..134		7/22 (32%)
		leucine-rich repeat	124..147	CDD:275380	5/22 (23%)
		PRK15370	<129..>349	CDD:185268	33/105 (31%)
		LRR 3	135..158		6/22 (27%)
		leucine-rich repeat	148..168	CDD:275380	7/23 (30%)
		LRR 4	159..179		7/23 (30%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		LRR 5	180..203		7/22 (32%)
		leucine-rich repeat	193..218	CDD:275380	7/24 (29%)
		LRR 6	204..229		8/24 (33%)
		leucine-rich repeat	219..239	CDD:275380	4/11 (36%)
		LRR 7	230..250		55/176 (31%)
		leucine-rich repeat	240..263	CDD:275380
		LRR 8	251..274
		leucine-rich repeat	264..288	CDD:275380
		LRR 9	275..299
		LRR 10	300..319
		leucine-rich repeat	309..347	CDD:275380
		LRR 11	320..358
		LRR 12	359..378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000