DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxn and lrrc17

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	XP_004913080.1	Gene:	lrrc17 / 101732309	XenbaseID:	XB-GENE-1010987	Length:	428	Species:	Xenopus tropicalis

Alignment Length:	449	Identity:	93/449 - (20%)
Similarity:	154/449 - (34%)	Gaps:	122/449 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LQLLGLLLLLAGGVQSVYCPAGCTCLERTVRCIRAKL---SAVPKLPQDTQTLDLRFNHIEELPA 69
            ::::.||:||            |.|  :...|.:.|.   :..|...:.|.:...|:
Frog     1 MRVVTLLMLL------------CFC--KISECRKTKSNRENGKPNRTKKTSSTVKRY-------- 43

  Fly    70 NAFSGLAQLTTLFLNDNELAYLQDGALNGLTA----LRFVYLNNNRLSRLPATIFQRMPRLEAIF 130
              ..||...|.::||:..|...:....:.|.|    |..:.|..|.:..|....|.:..:::::.
Frog    44 --APGLPCETYIYLNEKYLDCQEKRQTSVLPAWPEDLIHILLARNLIRILKNNAFSKFQKVKSLD 106

  Fly   131 LENNDIWQLPAGLFDNLPRLNRLIMYNNKLTQLPVDGFNRLNNLKRLRLDGNAIDCNCGVYSLWR 195
            |:.|:|.::....|..|.||..|::.:||:..|..:.|..|..|..|||..|..||||.:.||..
Frog   107 LQQNEIIKIENLAFYGLKRLTTLLLQHNKIKVLSEEVFIHLPLLSYLRLYDNPWDCNCELESLVT 171

  Fly   196 RWHLDVQRQLVSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVELSCEVT 260
            ...:...|.|.:.: .|..|  ::.:|..      .|...|                 ||.|:..
Frog   172 LLKIPRNRNLGNYA-KCETP--IEMKGLK------LKTVSP-----------------ELICQDR 210

  Fly   261 GLPRPQITWMHNTQELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQPVRLVV 325
            .:....|.....|:.:.........:.|..:|..|              |.|   |.|.|..:.
Frog   211 TMEPQHIEGPKVTRPIVDSSLCHTYLYPVATLDCR--------------RKE---LHSVPTDIA- 257

  Fly   326 NGGNHPLDSPIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQPHDQIVALHGSGHVLLDCAA 390
                 |....:|..:|::               ..|.| ..|...|:.:|:.|:.:|..|:|.||
Frog   258 -----PDIVKLDLSNNKI---------------KQLQS-RQFVDTPNLEILNLNSNGIELIDPAA 301

  Fly   391 -SGWPQPDIQWFVNGRQLLQSTPSLQLQAN----------GSLILLQPNQLSAGTYRCE 438
             ||               |.:...|.|..|          ..|..|:...|....:||:
Frog   302 FSG---------------LMNLQELDLSNNTLFYIHYGVLEDLYFLKKLWLRDNPWRCD 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064	25/113 (22%)
		leucine-rich repeat	54..77	CDD:275380	4/22 (18%)
		LRR_8	55..112	CDD:290566	12/60 (20%)
		leucine-rich repeat	78..101	CDD:275380	5/22 (23%)
		leucine-rich repeat	102..125	CDD:275380	5/22 (23%)
		LRR_8	124..184	CDD:290566	18/59 (31%)
		leucine-rich repeat	126..149	CDD:275380	5/22 (23%)
		LRR_4	148..185	CDD:289563	13/36 (36%)
		leucine-rich repeat	150..173	CDD:275380	7/22 (32%)
		Ig	240..325	CDD:299845	13/84 (15%)
		IG_like	242..325	CDD:214653	13/82 (16%)
		I-set	366..450	CDD:254352	20/84 (24%)
		Ig	384..451	CDD:143165	15/66 (23%)
		I-set	458..546	CDD:254352
		Ig	472..536	CDD:299845
		I-set	553..644	CDD:254352
		Ig	570..643	CDD:299845
		An_peroxidase	777..1317	CDD:281139
		peroxidasin_like	898..1338	CDD:188658
		VWC	1465..1523	CDD:278520
lrrc17	XP_004913080.1	leucine-rich repeat	58..77	CDD:275380	3/18 (17%)
		leucine-rich repeat	78..101	CDD:275380	5/22 (23%)
		LRR	<86..>319	CDD:227223	67/312 (21%)
		LRR_8	101..159	CDD:338972	17/57 (30%)
		leucine-rich repeat	102..125	CDD:275380	5/22 (23%)
		leucine-rich repeat	126..149	CDD:275380	7/22 (32%)
		leucine-rich repeat	150..211	CDD:275380	21/86 (24%)
		leucine-rich repeat	212..259	CDD:275380	10/69 (14%)
		leucine-rich repeat	260..283	CDD:275380	5/38 (13%)
		LRR_8	262..316	CDD:338972	18/84 (21%)
		leucine-rich repeat	284..307	CDD:275380	10/37 (27%)
		leucine-rich repeat	308..331	CDD:275380	4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910