DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxn and lrig1

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	XP_002938412.1	Gene:	lrig1 / 100491453	XenbaseID:	XB-GENE-494193	Length:	1043	Species:	Xenopus tropicalis

Alignment Length:	896	Identity:	187/896 - (20%)
Similarity:	305/896 - (34%)	Gaps:	283/896 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PAGCTCLER---TVRCIRAKLSAVP----KLPQDTQ-----------------------TLDLRF 61
            |.....|.|   |:|..:.::|.:|    :||:.||                       .|.|:.
Frog   167 PGSFDSLSRSLLTLRLSKNRISQLPVKVFRLPRLTQLELNRNRIRLIEGLTFQGLESLEVLKLQR 231

  Fly    62 NHIEELPANAFSGLAQLTTLFLNDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPRL 126
            |:|.:|...||.||:::..|.|.:|.|..:..|:|.||.:|:.::|::|.:|.:.:..:....:|
Frog   232 NNISKLTDGAFWGLSRMQILHLENNSLTEVNSGSLYGLLSLQQLHLSHNSISTISSAGWSFCQKL 296

  Fly   127 EAIFLENNDIWQLPA-------------------------------------------------- 141
            :.:.|.:|::.:|..
Frog   297 QELVLSHNNLTRLDEGSLADLGVLDVLRLSYNSISHIAEGAFKGLKSLRILELDHNEISGTIEDT 361

  Fly   142 -GLFDNLPRLNRLIMYNNKLTQLPVDGFNRLNNLKRLRLDGNAID-------------------- 185
             |.|..|..||:|.::.||:..:....|:.:.:|:.|.|..||:.
Frog   362 NGAFIGLESLNKLTLFGNKIKSVAKRAFSGIESLEHLNLGENALRSVHSEAFGEMKNLKELVVGS 426

  Fly   186 ----CNCGVYSLWRRWHLDVQRQLVSISLTCAAPQMLQNQGFSSLGEHHFKC---AKPQFLVAPQ 243
                |:|  :..|....|..:|....:..:||.|..|.|....|:....|.|   .|||..|.|:
Frog   427 SSFLCDC--HLKWLPQWLTSRRLQTKVKASCAHPGSLNNTSIFSVPPRSFVCDDLPKPQIRVQPE 489

  Fly   244 DAQVAAGEQVELSCE-VTGLPRPQ-ITWMHNTQELGLEEQAQAEILPSGS------------LLI 294
            ......|:.:..:|. .:..|.|. ..|..:.:.|   ..|:.|...||:            |.:
Frog   490 TTMAVLGKAIRFTCSAASSSPSPMTFAWKKDNEIL---HNAEVENFASGTEREGEVTEYTTILHL 551

  Fly   295 RSADTSDMGIYQCIARNEMGALRSQPVRLVVNGGNHPLDSPIDARSNQVWADAGTPMHGATPLPS 359
            |:...:..|.||||..|:.|...|...||.||
Frog   552 RNLTFAHEGRYQCIITNDFGPSYSSKARLTVN--------------------------------- 583

  Fly   360 PLPSPPHFTHQPHDQIVALHGSGHVLLDCAASGWPQPDIQWFVNGRQLLQSTPSLQLQA---NGS 421
            .|||   |...|.|.  .:.......|:|||.|.|.|:|.|..:|.....:....::..   :..
Frog   584 VLPS---FIKTPRDS--TIRAGTRARLECAADGHPTPEIAWQKDGGTDFPAARERRMHVMPDDDV 643

  Fly   422 LILLQPNQLSAGTYRCEARNSLGSVQATARIELKELPEILTAPQSQTIKLGKAFVLECDADGNPL 486
            ..::.......|.|.|.|:||.|||.|.|.:.:.|:|.::...:.:.:..|....|:|.|.|:|.
Frog   644 FFIMDVKIEDMGVYSCTAQNSAGSVSANATLTVLEMPFLVHPLEDRVVSTGATLALQCKASGSPP 708

  Fly   487 PTIDWQLNGVPLPGNTPDLQLENE-----NTELVVGAARQEHAGVYRCTAHNENGETSVEATIKV 546
            |.|.|      |.|:.|.:..|..     |..|::.....|.||.|.|...|         |:..
Frog   709 PRITW------LKGDEPLVMTERHHYTPGNQLLIIRQVMSEDAGKYTCEMSN---------TLGT 758

  Fly   547 ERSQSPPQLAIEPSNLVAITGTTIELPCQADQPE-DGL-----------------QISWRHDGRL 593
            ||:.|.          |:|..|.   .||.::.: :|:                 .:.|   ..:
Frog   759 ERAYSH----------VSIASTA---GCQGEKDKMEGMMTFGIITIAVVCSIVLTSLVW---VCI 807

  Fly   594 IDPNVQLAEKYQISGAGSLFVKNVTIPDGGRYECQLKNQFGRASASALVTIRNNVDLAPGDRYVR 658
            |....:.:|.|.::......|.    ||...|   |.:| |..|:...|.        |......
Frog   808 IYQTRKKSEVYSVTNTDETIVP----PDVPSY---LSSQ-GLCSSDGSVN--------PEAEACS 856

  Fly   659 IAF----------AEAAKEID-------------LAINNTLD--MLFSNRSDKAPPNYGELLRVF 698
            :|:          .||.|..|             :...:.||  ..:|::||..|.....:...:
Frog   857 VAYRQPRLCTCSSGEACKTADGLFGPESTGFGFQVVCTDCLDGGAGYSSKSDYCPQTVQSVDCSY 921

  Fly   699 RFPTGEARQLARAAEIYERTLVN------IRKH----VQEGDNLTMKSEEY 739
            :.|.|.          ::|.:.|      :..|    :.||.||......|
Frog   922 QKPAGS----------HDRYMCNGDTPTALSYHHNAAMDEGSNLESGGNMY 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064	36/183 (20%)
		leucine-rich repeat	54..77	CDD:275380	11/45 (24%)
		LRR_8	55..112	CDD:290566	21/79 (27%)
		leucine-rich repeat	78..101	CDD:275380	8/22 (36%)
		leucine-rich repeat	102..125	CDD:275380	4/22 (18%)
		LRR_8	124..184	CDD:290566	17/110 (15%)
		leucine-rich repeat	126..149	CDD:275380	7/73 (10%)
		LRR_4	148..185	CDD:289563	11/36 (31%)
		leucine-rich repeat	150..173	CDD:275380	6/22 (27%)
		Ig	240..325	CDD:299845	24/98 (24%)
		IG_like	242..325	CDD:214653	23/96 (24%)
		I-set	366..450	CDD:254352	23/86 (27%)
		Ig	384..451	CDD:143165	20/69 (29%)
		I-set	458..546	CDD:254352	23/92 (25%)
		Ig	472..536	CDD:299845	21/68 (31%)
		I-set	553..644	CDD:254352	19/108 (18%)
		Ig	570..643	CDD:299845	15/90 (17%)
		An_peroxidase	777..1317	CDD:281139
		peroxidasin_like	898..1338	CDD:188658
		VWC	1465..1523	CDD:278520
lrig1	XP_002938412.1	LRRNT	28..59	CDD:214470
		leucine-rich repeat	57..80	CDD:275378
		PLN00113	<58..>370	CDD:215061	39/202 (19%)
		leucine-rich repeat	104..127	CDD:275380
		leucine-rich repeat	128..151	CDD:275380
		leucine-rich repeat	152..199	CDD:275380	8/31 (26%)
		leucine-rich repeat	200..223	CDD:275380	2/22 (9%)
		leucine-rich repeat	224..247	CDD:275380	9/22 (41%)
		leucine-rich repeat	248..295	CDD:275380	12/46 (26%)
		leucine-rich repeat	272..292	CDD:275380	4/19 (21%)
		leucine-rich repeat	296..319	CDD:275380	4/22 (18%)
		leucine-rich repeat	320..343	CDD:275380	0/22 (0%)
		LRR_8	343..405	CDD:338972	13/61 (21%)
		leucine-rich repeat	344..370	CDD:275380	3/25 (12%)
		leucine-rich repeat	371..394	CDD:275380	6/22 (27%)
		leucine-rich repeat	395..413	CDD:275380	5/17 (29%)
		LRRCT	429..477	CDD:214507	12/49 (24%)
		leucine-rich repeat	445..471	CDD:275380	7/25 (28%)
		IG	488..582	CDD:214652	23/96 (24%)
		Ig_1	603..677	CDD:143240	21/73 (29%)
		I-set	680..759	CDD:369462	23/93 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910