DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxn and pxdn

DIOPT Version :9

Sequence 1:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster
Sequence 2:	XP_009291604.1	Gene:	pxdn / 100332937	-ID:	-	Length:	1468	Species:	Danio rerio

Alignment Length:	1544	Identity:	628/1544 - (40%)
Similarity:	876/1544 - (56%)	Gaps:	109/1544 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRFMLLMLQLLGLLLLLAGGVQSVYCPAGCTCLERTVRCIRAKLSAVPKLPQDTQTLDLRFNHIE 65
            :|.:...|.:|.:.||.:|..:...||:.|.|...||||:...|.:||.:...|..||||||.|:
Zfish     6 VRNLPCFLSVLSVFLLSSGPYRVSSCPSRCLCFRTTVRCMHLNLESVPAVLPQTTILDLRFNKIK 70

  Fly    66 ELPANAFSGLAQLTTLFLNDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPRLEAIF 130
            :|...:|..|..|.||.||:|.:..:..||...|..|:::||..|.:..:....|:.:..||.::
Zfish    71 DLQPGSFKRLKNLNTLLLNNNHIRRIPRGAFEDLENLKYLYLYKNEIQAIDREAFKGLVSLEQLY 135

  Fly   131 LENNDIWQLPAGLFDNLPRLNRLIMYNNKLTQLPVDGFNRLNNLKRLRLDGNAIDCNCGVYSLWR 195
            |..|:|..|....|.:||:|.||.::||:::.|.:..|:.|.::||||||.||:.|:|.:.
Zfish   136 LHFNNIESLEPESFSHLPKLERLFLHNNRISHLALGTFSHLQSMKRLRLDSNALHCDCELL---- 196

  Fly   196 RWHLDVQRQL-----VSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVEL 255
             |..|:.:|.     ...:.||..|..||.:..::|..|...|..|:....|||..|.:|..|..
Zfish   197 -WLADLLKQYAESGNAQAAATCDYPNRLQGRSVATLTAHELNCEVPRITSEPQDVDVTSGNTVYF 260

  Fly   256 SCEVTGLPRPQITWMHNTQELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQP 320
            :|...|.|:|||.|:.|...|.:.:..:..:|..|:|:|:....:|.|:|||:|:|..|.:::..
Zfish   261 TCRAEGNPKPQIIWLRNNNALNMRDDTRLNLLEDGTLMIQDTRETDQGVYQCMAKNVAGEVKTSE 325

  Fly   321 VRLVVNGGNHPLDSPIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQPHDQIVALHGSGHVL 385
            |.|..            .||                     ||.|.|..||.:..|.:..|  |.
Zfish   326 VTLRY------------FRS---------------------PSRPSFVIQPQNTEVLVGES--VT 355

  Fly   386 LDCAASGWPQPDIQWFVNGRQLLQSTPSLQLQANGSLILLQPNQLSAGTYRCEARNSLGSVQATA 450
            |:|:|:|.|||.:.|....:..|...|.:.:..:|.|.:...:|...|.|.|.|.|::.::.|.|
Zfish   356 LECSATGQPQPRVTWTRGDQSALPVDPRINITPSGGLFIQNIHQADGGQYTCFASNNVDTIHANA 420

  Fly   451 RIELKELPEILTAPQSQTIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQLENENTELV 515
            .|.::..|:....||.|::..|:.....|:|.|.|.|.|.|...|.|||.:...:.|...:  |.
Zfish   421 YIIVQARPQFTVTPQDQSVLEGQTVDFPCEASGFPQPVIAWTRGGSPLPNDRRHVVLSTGS--LR 483

  Fly   516 VGAARQEHAGVYRCTAHNENGETSVEATIKVERSQSPPQLAIEPSNLVAITGTTIELPCQADQPE 580
            :........|.|.|.|.:..|.......:.:.:|.: |.....|.:|...:|:.:::||.| |.|
Zfish   484 ISRVALHDQGQYECQAVSPVGTARAAVHLNILQSVT-PVFTSAPRDLTVESGSDVQIPCSA-QGE 546

  Fly   581 DGLQISWRHDGRLIDPNVQLAE--KYQISGAGSLFVKNVTIPDGGRYECQLKNQFGRASASALVT 643
            ....|:|..||      ||:.|  |:.|:..|.|.|.:|.:.|||||||..:|..|.:|:|.::|
Zfish   547 PTPIITWSKDG------VQITESGKFHINPDGYLEVHDVGLADGGRYECVARNSIGYSSSSMVLT 605

  Fly   644 IRNNVDLAPGDRYVRIAFAEAAKEIDLAINNTLDMLFSNRSDKAPPNYGELLRVFRFPTGE-ARQ 707
            ::.......||.:|..:..||.:.|:.||::|...||    |.:|....|||.:||:|... ..:
Zfish   606 VQVPQVSREGDPFVSTSLEEAIRSINSAIDSTRRQLF----DGSPRTPAELLALFRYPRDPYTVE 666

  Fly   708 LARAAEIYERTLVNIRKHVQEGDNLTMKSEEYEFRDLLSREHLHLVAELSGCMEHREMPNCTDMC 772
            .|||.||:|:||:.|::||.:|..:......|.:.||:|...|.::|.||||..||.:.||:|:|
Zfish   667 QARAGEIFEQTLLLIQRHVNQGLMVDTNGTAYRYNDLVSPRFLDMIANLSGCTAHRRINNCSDIC 731

  Fly   773 FHSRYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARLVSTS 837
            ||.:||:.||||||||||.||||||.|.||..|:|:|||::|.|.|: ..::|:..|..|||||:
Zfish   732 FHQKYRTHDGTCNNLQHPMWGASLTPFERLLKPVYDNGFNLPRGTTE-RWHNGYPLPLPRLVSTT 795

  Fly   838 LVATKEITPDARITHMVMQWGQFLDHDLDHAIPSVSSESW-DGIDCKKSCEMAPPCYPIEVPPND 901
            ::.|:.||||.|.|||:||||||||||||..:.|:|...: ||..|...|...|||:||..||||
Zfish   796 MIGTETITPDDRYTHMLMQWGQFLDHDLDSTVVSLSQSRFSDGQLCTSVCTNDPPCFPIMFPPND 860

  Fly   902 PRVRNR--RCIDVVRSSAICGSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTAFAQELRNLT 964
            ||.|..  ||:..||||.:||||||||..:||..|||:||||||||||.|||.|...|:|:|:|.
Zfish   861 PRQRRNGARCMFFVRSSPVCGSGMTSLLMNSVYPREQMNQLTSYIDASNVYGSSQHEAEEIRDLA 925

  Fly   965 SQEGLLRVGVHFPRQKDMLPFAAPQDGMDCRRNLDENTMSCFVSGDIRVNEQVGLLAMHTIWMRE 1029
            |..|:||.|:.....|.:||||.... .:|.|:.:|:.:.||::||.|.|||:||.||||:|:||
Zfish   926 SHRGMLRQGIVQRTGKPLLPFATGPP-TECMRDENESPIPCFLAGDHRANEQLGLTAMHTVWLRE 989

  Fly  1030 HNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEMMGEYQGYNPQLNP 1094
            ||||||:|.::|.||||||:|.||||||||||||||:.||||.|:||:||.:||:|.||||.:|.
Zfish   990 HNRIASELLRLNPHWDGDTIYHEARKIVGAQMQHITYNQWLPKILGEAGMRIMGDYTGYNPNINA 1054

  Fly  1095 SIANEFATAALRFGHTIINPILHRLNETFQPIPQGHLLLHKAFFAPWRLAYEGGVDPLMRGFLAV 1159
            .|.|.|||||.|||||:|||||:||:|.||||.|||:.||||||:|:|:..|||:|||:||...|
Zfish  1055 GILNAFATAAFRFGHTLINPILYRLDENFQPIQQGHISLHKAFFSPFRIVNEGGIDPLLRGLFGV 1119

  Fly  1160 PAKLKTPDQNLNTELTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYRKLCNLTVAQDFEDLA 1224
            ..|::...|.|||||||:||..||||||||||:|||||||||:|.||.||..||||.||.||||.
Zfish  1120 AGKMRMSTQLLNTELTERLFSMAHAVALDLAAMNIQRGRDHGIPSYNDYRVFCNLTSAQTFEDLK 1184

  Fly  1225 GEISSAEIRQKMKELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLRDGDRLYYENP 1289
            .||.:..:|:|::.|||.|.|||::...:.|:.|.|.::||...|||..||:|||||||.:||||
Zfish  1185 NEIQNPSVREKLQRLYGTPLNVDLFPALMAEELVPGSRLGPTLMCLLATQFKRLRDGDRFWYENP 1249

  Fly  1290 GVFSPEQLTQIKQANFGRVLCDVGDNFDQVTENVFILAKHQGGYKKCEDIIGINLYLWQEC---- 1350
            |.|||.||||:||.:..|||||.|||..::..:.|.:|....||..|.|:..|:|.:||:|
Zfish  1250 GSFSPAQLTQLKQTSLSRVLCDNGDNITRIQSDAFSVADLPHGYGSCADLPKIDLRMWQDCCEDC 1314

  Fly  1351 ---GRCNSPPAIFDSYIPQTYTKRSNRQKRDLGKEND---EVATAESYDSPLESLYDVNEERVSG 1409
               |:.|:....|.......::....::..:...||.   |.|......||..|    .|.....
Zfish  1315 RTKGQFNALSFHFRGRRSAEHSYAEEKKPANNLTENSSTLEDAAVNITVSPKSS----TEPSAKD 1375

  Fly  1410 LEELIGSFQKELKKLHKKLRKLEDSCNSADSEPVAQVVQLAAAPPQLVSKPKRSHCVDDKGTTRL 1474
            .::.:...||.:..|.|::::||                         .:..|:.|.|:.|..|.
Zfish  1376 FQDFVTDMQKTITSLRKQIKRLE-------------------------GRVSRTDCADEDGRERA 1415

  Fly  1475 NNEVWSPDVCTKCNCFHGQVNCLRERCGEVSCPPGVDPLTPPEACCPHC 1523
            :.|.|..:.||.|.|...||.|..|:|....|...|   ||..:|||.|
Zfish  1416 DGESWRKNPCTMCQCKAAQVTCFVEKCAPAVCETSV---TPSGSCCPVC 1461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064	39/109 (36%)
		leucine-rich repeat	54..77	CDD:275380	11/22 (50%)
		LRR_8	55..112	CDD:290566	23/56 (41%)
		leucine-rich repeat	78..101	CDD:275380	9/22 (41%)
		leucine-rich repeat	102..125	CDD:275380	5/22 (23%)
		LRR_8	124..184	CDD:290566	24/59 (41%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		LRR_4	148..185	CDD:289563	17/36 (47%)
		leucine-rich repeat	150..173	CDD:275380	8/22 (36%)
		Ig	240..325	CDD:299845	29/84 (35%)
		IG_like	242..325	CDD:214653	29/82 (35%)
		I-set	366..450	CDD:254352	25/83 (30%)
		Ig	384..451	CDD:143165	20/66 (30%)
		I-set	458..546	CDD:254352	23/87 (26%)
		Ig	472..536	CDD:299845	18/63 (29%)
		I-set	553..644	CDD:254352	33/92 (36%)
		Ig	570..643	CDD:299845	29/74 (39%)
		An_peroxidase	777..1317	CDD:281139	327/542 (60%)
		peroxidasin_like	898..1338	CDD:188658	264/441 (60%)
		VWC	1465..1523	CDD:278520	22/57 (39%)
pxdn	XP_009291604.1	LRRNT	31..57	CDD:214470	11/25 (44%)
		leucine-rich repeat	59..106	CDD:275378	20/46 (43%)
		LRR_4	105..146	CDD:289563	11/40 (28%)
		LRR_8	106..165	CDD:290566	19/58 (33%)
		leucine-rich repeat	107..130	CDD:275378	5/22 (23%)
		LRR_4	130..168	CDD:289563	14/37 (38%)
		leucine-rich repeat	131..154	CDD:275378	8/22 (36%)
		leucine-rich repeat	155..178	CDD:275378	8/22 (36%)
		leucine-rich repeat	179..191	CDD:275378	8/11 (73%)
		LRRCT	187..238	CDD:214507	14/55 (25%)
		Ig	241..328	CDD:299845	29/86 (34%)
		I-set	241..328	CDD:254352	29/86 (34%)
		Ig	341..424	CDD:299845	26/84 (31%)
		IG_like	343..424	CDD:214653	25/82 (30%)
		I-set	428..514	CDD:254352	23/87 (26%)
		Ig	441..514	CDD:299845	19/74 (26%)
		I-set	520..606	CDD:254352	33/92 (36%)
		Ig	537..605	CDD:299845	29/74 (39%)
		An_peroxidase	736..1277	CDD:281139	327/542 (60%)
		peroxidasin_like	857..1296	CDD:188658	263/439 (60%)
		VWC	1410..1461	CDD:214564	20/53 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584263
Domainoid	1	1.000	676	1.000	Domainoid score	I137
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1148	1.000	Inparanoid score	I203
OMA	1	1.010	-	-		QHG46064
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	1	1.000	-	-		oto41596
orthoMCL	1	0.900	-	-		OOG6_105829
Panther	1	1.100	-	-	O	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2950
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910