DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12182 and Gtf3c4

DIOPT Version :9

Sequence 1:	NP_001286922.1	Gene:	CG12182 / 38324	FlyBaseID:	FBgn0028504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001102943.1	Gene:	Gtf3c4 / 685539	RGDID:	1592609	Length:	818	Species:	Rattus norvegicus

Alignment Length:	784	Identity:	150/784 - (19%)
Similarity:	253/784 - (32%)	Gaps:	257/784 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GSKSEVITLELSSKFMVVDPFPYFVAIYDSNAAETRPLDVLANKVDLVAIYDSCDVLEAQHLALD 117
            |||:||  .|...|         |.:..|...::|..||.:.|.             |.:
  Rat   117 GSKTEV--AECKEK---------FASSKDPTISQTFMLDRMFNP-------------EGK----- 152

  Fly   118 PAYTAVCSVAVPPAR-LTAVKRAPK-LAANGNLLLGSLNTYGSLSLINKSAEYNRWNPVEGLNIA 180
                     |:||.| ......:|. ..|||..||.:|.....|::   ....||...|:.:::.
  Rat   153 ---------ALPPMRGFKYTSWSPMGCDANGRCLLAALTMDNRLTV---QVNLNRLQWVQLVDLT 205

  Fly   181 ETLRDTL-----------LPEVDIAKIKDFK---SYQEYINPAWITMFAWLP-----DDADATGQ 226
            |...|.|           .||.::....:|:   |.|..:...|.::.....     :..|.:..
  Rat   206 EIYGDRLYETSYRLSKNEAPEGNLGDFAEFQRRHSMQTPVRMEWSSICTTQQVKHNNECRDVSSV 270

  Fly   227 HVLVL---GTAAGSLWLLTLSADVKTLLS---------------------HQETKTSMGRICHIQ 267
            .:.||   |..|  :|...|....|..:|                     |...|.|.
  Rat   271 LLAVLFENGNIA--VWQFQLPFVGKESISSCNTIESGISSPSVLFWWEYEHSNRKMSG------- 326

  Fly   268 AFKDLLLVGDSNGLIHLYQLP-----AKGNTALALVKPLWEKADRMGLQMAVITEC-------PR 320
                 |:||.:.|.:.:  ||     .||...|.....||::.|::.:..   .:|       .:
  Rat   327 -----LIVGSAFGPVKI--LPVNLKAVKGYFTLRQPVVLWKEMDKLPVHS---IKCVPLYHPYQK 381

  Fly   321 MDCYYITCCKAAHLLTWSMPRTGSTDCL----QARIYVGGMKITALCSLENSSYVA----GTAGS 377
            ..|..:...:.:::. |         ||    :|.:.|....:|.|.||...|..|    ||..:
  Rat   382 CSCSLVVAARGSYVF-W---------CLLLISKAGLNVHNSHVTGLHSLPIVSITADKQNGTVYT 436

  Fly   378 CLSCVQI-----IHENNQLSLQMQSIAMG-VLQDFQVMGLCTSRHKNLMTLLLYR---------N 427
            |.|..::     |..:..|..:.|.|.:. |....:..|:..|.....:.::...         |
  Rat   437 CSSDGKVRQLIPIFTDVALKFEHQLIKLSDVFGSVRTHGIAVSPCGAYLAIITTEGMVNGLHPVN 501

  Fly   428 KEYLNETVSQK--NQLVMQVLKVGNQDPLDQLVRHLESNKPMNHYTDLLAGLRLHVFAEENWQKF 490
            |.|..:.|:.|  .:...|:|:...|:...|:              ||:..:|..:..:::..:|
  Rat   502 KNYQVQFVTLKTFEEAAAQLLESSVQNLFKQV--------------DLIDLVRWKILKDKHIPQF 552

  Fly   491 MDFCPLDSIEFADTATEGQLQQLQIKFHVLQNVIRLQSSHLQLTVHIQKSRDELQLLLAMLNITH 555
            :.......||     :.|.....:.|..:|:  |..||        :|||..|     |:...||
  Rat   553 LHEALEKKIE-----SSGVTYFWRFKLFLLR--ILYQS--------MQKSPSE-----ALWKPTH 597

  Fly   556 IRLRLQFIGS--------LSKRSPFQEQAIKCMFEEAHRLINKLNDDFTEN-----HALGSTA-- 605
            ...::..:.|        ..:.....:|..|...:|.    :|...|..|.     .|:|.|.
  Rat   598 EDSKILLVDSPGMGDGEDEQQEEGTSKQGTKAGLQEK----SKEGGDTEETPEDSLTAVGDTGGR 658

  Fly   606 ----------RTFVEQMGNHI--QHLHEMLG-------------IP-------VISNPQKQLHRC 638
                      :..:|.:..|:  :|:..:||             ||       ::|:........
  Rat   659 EPIEEKLLEIQGKIEAVEMHLTREHMKRVLGEVYLHTWITENTSIPTRGLCNFLMSDEDYDDRTA 723

  Fly   639 SVSFVEISLSLERR----YCSLCNRQILFELDNLQELYESGR-----HLTCPVC----------H 684
            .|....||..:.::    .|||| ::||...|..|.:..:|.     .||...|          |
  Rat   724 QVLIGHISKKMNKQTFPERCSLC-KEILPFTDRKQAVCSNGHIWLRCFLTYQSCQSLIYRRCLLH 787

  Fly   685 GSFA 688
            .|.|
  Rat   788 DSIA 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12182	NP_001286922.1	zf-TFIIIC	<637..687	CDD:289431	16/68 (24%)
Gtf3c4	NP_001102943.1	TFIIIC_delta	61..250	CDD:403756	37/173 (21%)
Gtf3c4	NP_001102943.1	zf-TFIIIC	741..813	CDD:372246	15/52 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119923at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010