DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12182 and gtf3c4

DIOPT Version :9

Sequence 1:	NP_001286922.1	Gene:	CG12182 / 38324	FlyBaseID:	FBgn0028504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_021329082.1	Gene:	gtf3c4 / 568510	ZFINID:	ZDB-GENE-041008-147	Length:	770	Species:	Danio rerio

Alignment Length:	808	Identity:	141/808 - (17%)
Similarity:	275/808 - (34%)	Gaps:	262/808 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SDSDGDFIALSGSKSEVI---TLELSSKFMVVDPFPYFVAIYDSNAAETRPLDVLANKVDLVAIY 103
            |..:.||.|  |....|:   .::|.|....|:|..:        |.:.|......|.|.|:.:.
Zfish    21 SGPEDDFWA--GQGPIVLRDPAIKLLSPVSGVEPLSW--------AEDHRLAACNTNSVSLIELV 75

  Fly   104 DSCDVLE-AQHLALD----PAYTAVCSVAVPPAR-LTAVKRAPKLAANG---------------N 147
              ||:.. :|:|.|.    |..|..|.:.|...: :.|||.:   .||.               |
Zfish    76 --CDIHSLSQNLVLHRTHIPVPTTTCELKVGSEKDVRAVKES---FANSKDPVVSQMIMIDRVIN 135

  Fly   148 LLLGSLNTYGSLSLINKSAEYNRWNPV----------------EGLNIAET---LRDTLLPEVDI 193
            ...|.|:          ..:|..|:|:                ..|.|..:   |:.|||  :|:
Zfish   136 PQCGPLH----------GVKYTSWSPLGCDKLGRCLLAFLTLDNRLTIHSSHLQLQWTLL--LDL 188

  Fly   194 AKI----------------------KDFKSYQEY------INPAWITMFAWLPDDADATGQHV-- 228
            .::                      |||...|..      :...|.::.:.....:|...:.:
Zfish   189 TELYGEMLKTRKYSAQNDGTPPVSFKDFDELQRRFRMQTPVRMEWSSLCSMQQVQSDNAHKDINT 253

  Fly   229 ----LVLGTAAGSLWLLTLSADVK-TLLSHQETKTSMG--------RICHIQAFKDLLLVGDSNG 280
                :::......:|..:|..:.| :::|....|:.:.        :..|.......|::|.|.|
Zfish   254 VLLAVLMENGDVVVWQFSLPLNGKESVVSCSTIKSGVSSPSALTWWQYEHSGRKMSGLIIGSSVG 318

  Fly   281 LIHLYQLP-----AKGNTALALVKPLWEKADRMGLQ----MAVITECPRMDCYYITCCKAAHLLT 336
            .:.:  ||     .||...|.....||:::|::.:.    :.:.....:.:|..:...:..::.
Zfish   319 PVKI--LPVNIKAVKGYFTLRQPVVLWQESDQIPVHNIKCITLFHPHQKCNCSLVVAARGPYIF- 380

  Fly   337 WSMPRTGSTDCL----QARIYVGGMKITALCSLENSSYVAGTA----GSCLSCVQIIHENNQLSL 393
            |         ||    :|.:.|....||   .|.::..::.||    |:.|:| .:..:..:|:.
Zfish   381 W---------CLLLISKAGLNVHNSHIT---GLHSTPIISMTACHNNGTVLTC-SLDGKVKKLTT 432

  Fly   394 QMQSIAMGVLQDFQVM--GLCTSRHKNLMTLLLYRNKEYL----NETVS---QKNQLVMQVLKVG 449
            ....:|:...|:..|:  |:...|   :..:.:..|..||    ||.::   ....|..||..:.
Zfish   433 VFTDLAVEFKQEEIVLPEGVAGRR---IHGISISPNSAYLAVLSNEGMNNGFHPVALNYQVQFIT 494

  Fly   450 NQDPLDQLVRHLESNKPMNHYTDLLAGLRLHVFAEENWQKFMDFCPLDSIEFADTATEGQLQQLQ 514
            .:.|.:...:.|:::....: :|||..||..:..:::               ..:|.|..|::
Zfish   495 FKTPDEAAAKMLDAHSLFRN-SDLLDLLRWRILKDKS---------------IPSAYENNLEE-- 541

  Fly   515 IKFHVLQNVIRLQSSHLQLTVHIQKSRDELQLLLAMLNITHI-RLRLQFIGSLSKRSPFQEQAIK 578
                      :||:|                      ..|:: ||:|.|:.:|.|  ..|:...:
Zfish   542 ----------KLQTS----------------------GSTYLWRLKLFFLRTLHK--SMQKTPSE 572

  Fly   579 CMFEEAHRLINKL-----------NDDFTENHALGSTARTFVEQM---GNHI---------QHLH 620
            .:::...|....|           .|:..|:....:..|...|:|   |:.|         :::.
Zfish   573 ALWQPRRRSGQSLVGDGDEGGGGDEDEMMEDRQGDAEIREREERMKEIGSRIEAVESHLIRENMK 637

  Fly   621 EMLG-------------IP-------VISNPQKQLHRCSVSFVEISLSLERR----YCSLCNRQI 661
            ::||             :|       :.::|..:.....|....|...:.::    ||:||...:
Zfish   638 KVLGEVYLHTCVTQNTRVPTKGVCDFLTNDPANEDRAAKVLIGHIMNKMNKQTFPEYCALCKEIL 702

  Fly   662 LFELDNLQELYESGRHLTCPV----CHG 685
            .|......|.....|.|.|.:    |.|
Zfish   703 PFTDCKRAECKNGHRWLRCALSYQACQG 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12182	NP_001286922.1	zf-TFIIIC	<637..687	CDD:289431	13/57 (23%)
gtf3c4	XP_021329082.1	TFIIIC_delta	48..234	CDD:315351	38/210 (18%)
gtf3c4	XP_021329082.1	zf-TFIIIC	693..765	CDD:315353	11/38 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119923at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010