Protein Alignment dos and Gab2

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_445869.2
• Gene: Gab2 / 84477
• RGDID: 621367
• Length: 664
• Species: Rattus norvegicus
• Alignment Length: 869
• Identity: 185/869 - (21%)
• Similarity: 306/869 - (35%)
• Gaps: 288/869 - (33%)

  Fly     8 GWLIKSPPTKRIWRARWRRRYFTLKQGEI---PEQFCLEYYTDHNCRKLKGVIDLDQCEQVDCGL 69
            |||.||||.|::.|..|::|:|.|:.|.:   |:  .||||.:.:.:|...:|:|:.|||||.||
  Rat    12 GWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPD--VLEYYKNEHSKKPLRIINLNFCEQVDAGL 74

  Fly    70 RLENRKQKFQYMFDIKTPKRTYYLAAETEADMRDWVNCICQVCHLHDTKQSNELPLGAVGADENR 134
            ....::.:..::|||||.:||:||.|||||||..||..|||:|..:..::|         .|..|
  Rat    75 TFNKKELQDSFVFDIKTSERTFYLVAETEADMNKWVQSICQICGFNQAEES---------TDSLR 130

  Fly   135 TQHTSSSGGLSNSTQNTTTTSLHSSAGTTAPQASVPNAGGSAQLRRPAVIE-EQPMPSNAGNNNS 198
            ...::|.|..|:..:.:::..|.....::||..|          .:|.:.. |.||.|:
  Rat   131 NLSSASHGPRSSPAEFSSSQHLLRERKSSAPSHS----------SQPTLFTFEPPMSSH------ 179

  Fly   199 DSVYVNTEYSNRETMLCDANFDQQELLSAAQQQPPPSPATALYLNHSALIQAQAAAAAAEQLQQQ 263
                                  .|..||.:      :|...|||:               |...:
  Rat   180 ----------------------MQPALSTS------APQEYLYLH---------------QCISR 201

  Fly   264 QQQAARLAVSANGVVRKLPEHLVLTQQTLAEAAAQQHSSVQASPALSTASGPYIPISECFSGSPR 328
            :.:.:|.|..:.|..:|            ::.|.|:         |:.::|      .|.:|
  Rat   202 RTENSRSASFSQGTRQK------------SDTAVQK---------LAQSNG------HCING--- 236

  Fly   329 FLPGVPLPGADLAIPNNPTTPLNNLDPKFYDTPR-SHNNIGLNLTNDQSYS-PKITNLSLQQLAN 391
                                 ::|....||..|: |.:|...   .|.:|. |:    ||....:
  Rat   237 ---------------------VSNQVHGFYSLPKPSRHNTEF---KDSTYDLPR----SLASHGH 273

  Fly   392 NNASKQRSDSDSESVFTDDDEWAHPLP-----------LRENVDRSTRPSDSSIENESFVLTYSQ 445
            ..:|...|::|:|.|:|      ..:|           |.:|:|..|.|..:.....:|.|..:.
  Rat   274 TKSSLTGSETDNEDVYT------FKMPSNTLCREFGDLLVDNMDVPTTPLSAYQIPRTFTLDKNH 332

  Fly   446 RFSKMPEEGGAIVPPAEKSSKLAGAASLPEAGDQGTLDKLAKVLKNKNNLILDFKENEKIPRDLP 510
            ....:...|.:.:.|..:..| ...|..|..|.                           |:..|
  Rat   333 NAMTVATSGDSAIAPPPRPPK-PSQAETPRWGS---------------------------PQQKP 369

  Fly   511 QLSDTENTSPAIVARRNA---------HSAFIEESYDIPRSHQQPYYNVNQLLGERPVTSPHNSN 566
            .:.:...:..|.:.|||.         |.|...|:|:.|....          ||....|..:..
  Rat   370 PIGENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPTRGS----------GESASWSAESPG 424

  Fly   567 PIAASTPNLMAADLGAVAAISAAANPG--------LMGEAQAVASSPTS------------ARTL 611
            ..|....|..::|...|     ..|||        ..|:....|..|.|            :..|
  Rat   425 KTAVGRSNSASSDDNYV-----PMNPGSSTLLAMERAGDNSQSAYIPMSPGPHHFDPLGYPSTAL 484

  Fly   612 PRHCYTNAAPTKMEGNVFRYDFMEQADCPPVNRKLKP-KVAGGLP--VVEDKPPEEFPAKPPV-- 671
            |.|    ..|::  |:        :...|||||.||| :.|...|  :..:...:|.|.|.||
  Rat   485 PIH----RGPSR--GS--------EIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPVTK 535

  Fly   672 ---GVDQLTNKLGAAQLQQPIGPPSV----DRKCKPNAYKLGN--------SATMSPATRRSSGA 721
               .::...|. .::|..:||...|:    ....:.|...:.|        |.|.|||.|:|:|:
  Rat   536 SWSRINHTFNS-SSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPRKSTGS 599

  Fly   722 PLSMVLPHETDVHSPAAANAFFHETRTLPRQQHRHHPNSPGSMSVQHQRTASAAAAMMSLTAAAA 786
            ...:.|..:                              |||.|...:.:.|:..:...:.....
  Rat   600 VDYLALDFQ------------------------------PGSPSPHRKPSTSSVTSDEKVDYVQV 634

  Fly   787 PKQQAAAQTEHKLQYFDLDVTNKP 810
            .|::..|......::.|:..:::|
  Rat   635 DKEKTQALQNTMQEWTDVRQSSEP 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	51/109 (47%)
Gab2	NP_445869.2	PH-like	5..127	CDD:473070	52/125 (42%)
		Plasmodium_Vir	<541..>627	CDD:329056	21/116 (18%)