Protein Alignment dos and PLEKHS1

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_011538473.1
• Gene: PLEKHS1 / 79949
• HGNCID: 26285
• Length: 485
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 120/538 - (22%)
• Similarity: 188/538 - (34%)
• Gaps: 170/538 - (31%)

  Fly     7 EGWLIKSPPTKRIWR-ARWRRRYFTL-KQGEIPEQFCLEYYTDHNCRKLKGVIDLDQCEQVDCGL 69
            :.:.|||||::.... ..|::|:|.| |.||  :.|.|.||.||:.|   |.|::||...|:.|:
Human    24 QDYFIKSPPSQLFSSVTSWKKRFFILSKAGE--KSFSLSYYKDHHHR---GSIEIDQNSSVEVGI 83

  Fly    70 RLENRKQKFQYMF--------DIKTPKRTYYLAAETEADMRDWVNCICQVCHLHDTKQSN---EL 123
            ..:.:.|..|.||        .|:|..|.|:|.......::|||:.:..........|.|   ||
Human    84 SSQEKMQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEEL 148

  Fly   124 PLG-------------------AVGADENRT-------QHTSSSG-------GLSNSTQN----- 150
            .||                   |||:...|.       ...||.|       .||.:||:
Human   149 SLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKHLMEQSSPGFRQTHLQDLSEATQDVKEEN 213

  Fly   151 ------TTTTSLHSSAGTTAPQASVPNAGGSAQLRRPAVIEEQPMPSNAGNNNSDSVYVNTEYSN 209
                  :....|.:...::....|: ...|..|:........:||.|               |..
Human   214 HYLTPRSVLLELDNIIASSDSGESI-ETDGPDQVSGRIECHYEPMES---------------YFF 262

  Fly   210 RETMLCDANFDQQELLSAAQQQPPPSPATA---LYLNHSALIQAQA---------AAAAAEQLQQ 262
            :||        ..|.:.:::::|...|.|.   |:|      |.|.         |...|:....
Human   263 KET--------SHESVDSSKEEPQTLPETQDGDLHL------QEQGSGIDWCLSPADVEAQTTND 313

  Fly   263 QQQQAARLAVSANGVVRKLPEHLVLTQQTLAEAAAQQHSSVQASP------ALSTASGPYIPISE 321
            |:..|:...|..:.::..:|:          |:..::.:...:.|      ||:.|:| .|.:|:
Human   314 QKGSASLTVVQLSILINNIPD----------ESQVEKLNVFLSPPDVINYLALTEATG-RICVSQ 367

  Fly   322 CFSGSPR----FLPGVPLPGADLAIPNNPTTPLNNLDPKFYDTPRSHNNIGLNLTNDQSYSPKIT 382
             :.|.||    |..|..|    ||:        |:|      .|:|...:.|.||..........
Human   368 -WEGPPRLGCIFCHGDHL----LAV--------NDL------KPQSLEEVSLFLTRSIQKEDSFR 413

  Fly   383 NLSLQQLANNNASKQRS------DSDSESVFTD---DDEWAHPLPLRENVDRSTRPSDSSIENES 438
            .|| .|:|....::.|.      .||...|...   :.:|..        |..|.||.:
Human   414 ILS-YQVAFGEGTELRDRAPGFRTSDRHDVAKRACMESDWCR--------DSKTAPSTN------ 463

  Fly   439 FVLTYSQRFSKMPEEGGA 456
              |..|..|.|:....||
Human   464 --LCLSFLFCKIMTNDGA 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	37/117 (32%)
PLEKHS1	XP_011538473.1	PH-like	20..127	CDD:473070	35/107 (33%)