Protein Alignment dos and Raph1

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_006496385.1
• Gene: Raph1 / 77300
• MGIID: 1924550
• Length: 1318
• Species: Mus musculus
• Alignment Length: 999
• Identity: 191/999 - (19%)
• Similarity: 297/999 - (29%)
• Gaps: 304/999 - (30%)

  Fly     7 EG--WLIKSPPTKRIWRARWRRRYFTLKQGEIPEQFCLEYYTDHN----CRKLKGVIDLDQCE-- 63
            ||  ||      |...:..|::|||.|:...|       ||....    .|.|...:.||...
Mouse   453 EGVLWL------KDDGKKSWKKRYFLLRASGI-------YYVPKGKAKVSRDLVCFLQLDHVNVY 504

  Fly    64 -----------QVDCGLRLENR--KQKFQYMFDIKTPKRTYYLAAETEADMRDWVNCICQVCHLH 115
                       ..||.|.|::.  ::|.||   ||      ||..:....:..|||.|      .
Mouse   505 YGQDYRNKYKAPTDCCLALKHPQIQKKSQY---IK------YLCCDDARTLHQWVNGI------R 554

  Fly   116 DTKQSNELPLG---AVGADENRTQHTS-SSGGL---SNSTQNTTTTSLHSSAGTTAPQASVPNAG 173
            ..|...:|...   |:...|:....|| ||..:   |:|:....:.|.||:...:....::|...
Mouse   555 IAKYGKQLYTNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTLPTGH 619

  Fly   174 GSAQLRRPAVIEEQPMPSNAGNNNSDSVYVNTEYSNRE-TMLCDANFDQQELL---SAAQQQ--- 231
            ..:|....::..|   ....|....:|.....|..||. |.|......|.:::   :|:|..
Mouse   620 IRSQSTVSSIFSE---AWKRGTQLEESSKARMESMNRSYTSLMPPLSPQTKIITPYTASQPSPPL 681

  Fly   232 ---------------PPPSP-----------ATALYLNHSALIQAQAAA------------AAAE 258
                           |||.|           |..:::.:|.:.:.|.||            .|.:
Mouse   682 PPPPPPPPPPPPPPPPPPPPLPSQSAPSSGSAATMFVKYSTITRLQNAAQHSGTLFKSPTPPAMQ 746

  Fly   259 QLQQQQQQAARLAVSANGVVRKLPEHLVLTQQTLAEAAAQQHSSVQASPALSTAS--GPYIPISE 321
            .|....|..|::.|..|||:...|..   .......:|..|...|..:|:|...|  .|.:.|.:
Mouse   747 PLPLASQSKAQIVVPPNGVIPPPPPP---PPPPTPGSAMAQLKPVPCAPSLPQFSPQPPPLKIHQ 808

  Fly   322 CFSGSPRFLPGVPLPGADLAI---PNNPTTPLNNLDPKFYDTPRSHNNIGLNLTNDQSYSPKITN 383
             ....|:..|..|.|...:..   |..|..||..:.|                    |.|.|..:
Mouse   809 -VQHLPQTAPPTPPPAPPITATVPPQAPPKPLVTIPP--------------------SASTKTVS 852

  Fly   384 LSLQQLANNNASKQRSDSDSESVFTDD--------DEWAHPLP-LRENVDRSTRPSDSSIENESF 439
            ..:.|......:.....:..:.||...        ....||.| |.:......:|..|.:.....
Mouse   853 PVVAQAVPPTPAPPVPPAKKQPVFPVSHIPPTPPVQPTPHPPPTLPKQQSFGVKPPPSPLSPVPS 917

  Fly   440 VLTY---------------SQRFSKMPEEGGAIVPPAEKSSKLAGAASLPEAGDQGTLDKLAKVL 489
            |:..               ||....:|..|....|||.|:......:|:|....
Mouse   918 VVKQIASQFPPPPTPPPVDSQPLKSLPASGTPQSPPAVKAKPKWQPSSIPVPSP----------- 971

  Fly   490 KNKNNLILDF----KENEKI-------------------PRDLPQLSDTENTSPAIVARRNAHSA 531
                    ||    .|:..:                   |...|.:..|.:.:|
Mouse   972 --------DFPPPPPESSLVFPPPPPPAPAPAPPPPPPPPPPPPPVPPTASPTP----------- 1017

  Fly   532 FIEESYDIPRSHQQPYYNVNQLLGERPVTSPHNSNPIAAST------PNLMAADLGAVAAISAAA 590
                  |...|..:....::...|::|..:|..::.|.:.:      |...:.|    :.:|..|
Mouse  1018 ------DKGGSPGKKTSKMSSPGGKKPPPTPQRNSSIKSGSCAEHPEPKRPSVD----SLVSKFA 1072

  Fly   591 NPGLMGEAQAVASSPTSARTLPRHCY--------------TNAAPTKMEGNVFRYDFMEQADCPP 641
            .|...|........|.:|...|...:              .:|..:.:.|.  ..|.:.:...||
Mouse  1073 PPAESGSPSKETPPPPAAPPKPGKLHLSGVNLPGIHQQGIVSAKASVLSGR--GKDVVVEFPSPP 1135

  Fly   642 VNRKLKPKVAGGLPVVE-DKPPEEFPA------KPPVGV----DQLTNKLGAAQLQQPIGPPSVD 695
            .:....|..    |.:| ..||.|.||      .|.|.|    .||.:|....:...|..|...|
Mouse  1136 SDSDFPPPP----PEIELPLPPIEIPAVFSGNTSPKVAVVNPQPQLWSKTSVKKAPPPTRPKRND 1196

  Fly   696 --RKCKPNAYKLGNSATMSPATRRSSGAPLSMVLPHETDVHSPAAANAFFHETRTLPRQQHRHHP 758
              |..:.:..:.....|:.|....|..:.||:......|::            |||.|:....|
Mouse  1197 STRLTQADISEQPAMTTVVPQVPTSPKSSLSVQPGFLADLN------------RTLQRKSITRH- 1248

  Fly   759 NSPGSMSVQHQRTASAAAAMMSLTAAAAPKQQAAAQTEHKLQYFDLDVTNKPPLLNRSSMSVGNL 823
               ||:|......|...|.|                       .|:.:...||.|.......|
Mouse  1249 ---GSLSSSRMSRAEPTATM-----------------------DDMALPPPPPELLSDQQKAG-- 1285

  Fly   824 YSQGGNGASGMRFAGVEAGGARAP 847
              .||:..||  :|.:..|...||
Mouse  1286 --FGGSHISG--YATLRRGPPPAP 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	32/128 (25%)
Raph1	XP_006496385.1	RA_MRL_Lpd	320..409	CDD:340553
		PH_APBB1IP	445..567	CDD:269961	34/141 (24%)