Protein Alignment dos and plekhs1.2

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001070792.1
• Gene: plekhs1.2 / 768181
• ZFINID: ZDB-GENE-061013-702
• Length: 384
• Species: Danio rerio
• Alignment Length: 337
• Identity: 78/337 - (23%)
• Similarity: 131/337 - (38%)
• Gaps: 66/337 - (19%)

  Fly     8 GWLIKSPPTKRIWRARWRRRYFTLKQGEIPEQFCLEYYTDHNCR-KLKGVIDLDQCEQVDCGLRL 71
            |:|.||||.|.|  ..|:||:|.|.:.: .:.:.|.||.::..| |..|.|||.:...:......
Zfish    16 GYLNKSPPAKGI--KSWKRRFFVLSKVD-KDNYHLSYYRNNESRDKPLGTIDLSKISLLSTAPEA 77

  Fly    72 ENRKQKFQYMFDIKTP----------KRTYYLAAETEADMRDWVNCICQVCHLHDTKQSNELPLG 126
            .:|....|..|  |.|          .|.|:|..:...|:..|:|.|.........|..|
Zfish    78 HSRWPWIQKHF--KCPPSSVLFLTVETRDYFLIGQNSDDVDSWLNAITTALQNSQNKMQN----- 135

  Fly   127 AVGADE--NRTQHTSSSGGLSNSTQNTTT-----TSLHSSAGTTAPQA--SVPNAGGSAQLRRPA 182
               .||  ::.|...|..|..|..|.|.|     ....::..:|:||:  :.|.:..:||:....
Zfish   136 ---TDECDDKNQSIKSISGPMNYWQPTPTDQPDEKDSEAALMSTSPQSYYACPRSLFNAQVAESH 197

  Fly   183 VIEEQPMPSNAGNNNSDSVYVNTE--YSN------------RETMLCDANFDQQELLSAAQQQPP 233
            ..|:||....:.:....|.|::.:  |.:            |:..|.|...::.|     ::...
Zfish   198 KFEDQPDERKSEDPAVMSTYLSPQSYYDSPRTFFKAPVAEPRKRFLSDIKDEKVE-----EEDES 257

  Fly   234 PSPATALYLN----HSALIQAQAAAAAAEQLQQQQQQAAR-LAVSANGVVRKLPEHLVLTQQ--- 290
            |..||. |::    ..||...|.|.....:..:.:....: :.:|.:    .|..:||||::
Zfish   258 PEEATE-YISMAKVQMALEDDQKADTERTKTNETETHVEKEICISQD----SLMNNLVLTEEEGK 317

  Fly   291 -TLAEAAAQQHS 301
             .::|....|.|
Zfish   318 PCVSECLETQES 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	34/117 (29%)
plekhs1.2	NP_001070792.1	PH-like	13..125	CDD:473070	34/113 (30%)