Protein Alignment dos and grb7

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_003201390.1
• Gene: grb7 / 563649
• ZFINID: ZDB-GENE-091118-23
• Length: 530
• Species: Danio rerio
• Alignment Length: 564
• Identity: 105/564 - (18%)
• Similarity: 174/564 - (30%)
• Gaps: 192/564 - (34%)

  Fly   277 VVRKLPEHLVLTQQTLAEAAAQQHS-SVQASPA-----LSTASGPYIPI----SECFSGSPRF-- 329
            |.|:.|          .|...::|| ||:.||:     :||.... :|:    |...|....|
Zfish    12 VFRRSP----------VETVPRRHSVSVKYSPSSQNLQMSTPRSS-LPLNIRNSHSVSSKGEFRA 65

  Fly   330 --LPGVPLPGADLAIPNNPTTPLNNLDPKFYDTPRSHNNIGLNLTNDQSY------SPKITNLSL 386
              .|.:|.|..:|..|........:|..:  |.|...:...:.:.:|.::      |.:.|...:
Zfish    66 SSAPLIPNPFPELCSPTQSPVLTGSLGVR--DPPSDSSTHVVRVFSDATHCRSVLVSSRATAHDV 128

  Fly   387 QQLANNNASKQRSDSDSESVFTDDDEWA----------------HPLPLRENVDRSTRPSDSSIE 435
            .|:...:|.           .||::.||                |.|.|:.   :|:.|    :|
Zfish   129 CQMLAQSAH-----------CTDEESWALIEHHTALGLERCLEDHELVLQV---QSSWP----VE 175

  Fly   436 NESFVLTYSQRFSK----------MPE---EGGAIVPPAEKSSKL----AGAASLPE-------- 475
            .::.:| :.:.::|          .||   ...|.|.....||:|    ..:.|.||
Zfish   176 GDTKLL-FRKNYAKYEFFKKPVSFFPEHMISDSADVTKGMTSSELVQNMVKSGSCPEIQGFLHVR 239

  Fly   476 AGDQGTLDKLAKVLKNKNNLILDFKENEKIPRDLPQLSDTENTSPAIVARRNAHSAFIEESYDIP 540
            .|.:.:..||..||: ::.|....|...|.||.|....|.|:.:...|.....|       |..|
Zfish   240 EGGKKSWKKLYFVLR-RSGLYCSSKGQSKEPRHLQFTGDLEDLNVFTVFTGRKH-------YGAP 296

  Fly   541 RSHQQPYYNVNQLLGERPVTSPHNSNPIAASTPNLMAADLGAVAAISAAANPGLMGEAQAVASSP 605
            ..|                     ...|.:|.......||..:.|.|..:
Zfish   297 GEH---------------------VFCIKSSKERFRGQDLKLMCADSEQS--------------- 325

  Fly   606 TSARTLPRHCYTNAAPTKMEGNVFRYDF-MEQADCPPVNRKLKPKVAGGLPVVEDKPPEEFPAKP 669
                   |.|:..|......|...:.:: :.|      :|..||          .||..:|..:.
Zfish   326 -------RTCWITAFRLFKHGTQLQQNYQLSQ------SRLHKP----------SKPDSKFTDRD 367

  Fly   670 P--VGVDQLTNKLGAAQLQQPIG----------------------PPSVDRKCKPNAYKL----- 705
            .  |.:| .:.|.|...:|.|..                      ||:......|..:::
Zfish   368 ESMVAMD-FSGKSGGRVIQNPHEAHNAEQEEGHSWRKREALRHSLPPNSHGSQLPAVHRVQPWFH 431

  Fly   706 -GNSATMSPATRRSSGAPLSMVLPHETDVHSPAAANAFFHETRT 748
             |.|.|.:.......|....|.|..::.:|......:.:||.:|
Zfish   432 GGVSRTKAERLLEEQGGVDGMYLIRDSQLHVQCFVLSLWHELKT 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535
grb7	XP_003201390.1	Ubl1_cv_Nsp3_N-like	103..188	CDD:475130	16/103 (16%)
		PH_APBB1IP	225..347	CDD:269961	31/172 (18%)
		BPS	367..408	CDD:462644	6/41 (15%)
		SH2_Grb7_family	423..530	CDD:198197	10/53 (19%)