Protein Alignment dos and raph1b

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001352514.1
• Gene: raph1b / 560319
• ZFINID: ZDB-GENE-090311-54
• Length: 1565
• Species: Danio rerio
• Alignment Length: 938
• Identity: 188/938 - (20%)
• Similarity: 294/938 - (31%)
• Gaps: 315/938 - (33%)

  Fly     7 EG--WLIKSPPTKRIWRARWRRRYFTLKQGEIPEQFCLEYYTDHNCRKLKGVIDLDQCEQVDCGL 69
            ||  ||      |...:..|::|||.|:...|       |:....  |.|...||      .|.|
Zfish   471 EGVLWL------KEDGKKSWKKRYFLLRASGI-------YFVPKG--KAKASRDL------VCFL 514

  Fly    70 RL--------ENRKQKFQ----YMFDIKTP----KRTY--YLAAETEADMRDWVNCI-------- 108
            :|        ::.:.|::    |...:|.|    |..|  ||..:....:..|||.|
Zfish   515 QLDHVNVYYGQDYRSKYKAPTDYCLALKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQ 579

  Fly   109 -----------CQVCHLHDTKQSNELPLG--AVGADENRTQHTS-SSGGLSNSTQNTTTTSLHSS 159
                       .:..:...:..|..:..|  :|...|:::.|:| :..|:|:.     |:|.|
Zfish   580 LYVNYQEAMKRTEAAYDWSSLSSTSIKSGTSSVSIPESQSNHSSQTDSGMSDG-----TSSSH-- 637

  Fly   160 AGTTAPQASVPNAGGSAQLRRPAVIEEQPM-------------PSNAGNNNSDSVYVNTEYSNRE 211
                |...||.::..|...:|...|||...             .|::.::.|...:::.:..:..
Zfish   638 ----ARSQSVVSSIFSEAWKRGTQIEESTKARPESIRSTHSSHSSHSSHHVSQQQHLHAQQPHVH 698

  Fly   212 TML--------CDANFDQQELLSAAQQ-------------QPPPSPATA--------LYLNHSAL 247
            ::|        ..|....|.|..|..|             .|||.|.::        ::..:|.:
Zfish   699 SILQSRGSVTQAPAQAPTQTLAQAPPQVAPAPPPPPPPPPPPPPPPISSIPHHATPTMFAKYSTI 763

  Fly   248 IQAQAAAAAAE------QLQQQ--------QQQAARLAVSANGVVRKLP---------------- 282
            .:.|.|:.|..      |:|||        :.|:..:...||     :|
Zfish   764 TRLQNASQATSHHKPQPQIQQQVPPVPPPSKPQSNNIPSGAN-----IPPPPPPPPPASMPPPGS 823

  Fly   283 EHLVLTQQTLAEAAAQQHSSVQASPALSTASGPYIPI-SECFSGSPRFLP--GVPLPGADLAIPN 344
            ...||.....|.|...|.|....||.......|.:|: |:.....|..:|  ..|||      |.
Zfish   824 AMAVLKLGPPAAAVIPQISPSPPSPPPPPPPPPIMPVQSQPQPPPPPIMPMQSQPLP------PP 882

  Fly   345 NPTTPL--NNLDPKFYDTPRSHNNIGL----NLTNDQSYS----PKITNLSLQQLANNNASKQRS 399
            .|.||:  :||.|     |....:..|    .:|..||::    |.||.:....|
Zfish   883 PPITPMQSHNLPP-----PPPMQSHALPPPPPITPMQSHALPPPPPITPMQSHAL---------- 932

  Fly   400 DSDSESVFTDDDEWAHPLPLRENVDRSTRPSDSSIENESFVLTYSQRFSKMPEEGGAIVPPAE-- 462
                          ..|.|:......:..|.......:|..|......  ||.:...:.|||:
Zfish   933 --------------PPPPPITPMQSHALPPPPPITPMQSHALPPPPPI--MPMQSEPLPPPAQIM 981

  Fly   463 --KSSKLAGAASLPEAGDQGTLDKLAKVLKNKNNLILDFKENEKIPRDLPQLSDTENTSPAIVAR 525
              :|..|.....|.:...|........|         .| :::.:|...|.|.......|..:..
Zfish   982 PMQSHPLPPPPPLVQMQSQPMPPPPPTV---------SF-QSQPLPPPPPPLQANGLPPPPPLIT 1036

  Fly   526 RNAHSAFIEESYDIPRSHQQPYYNVNQLLGERPVTSPHNSN----PIAASTPNLMAADLGAVAAI 586
            .....||   ::..|.:.|.             |..|.|.|    |.....|..:|..|.....:
Zfish  1037 NGLKQAF---AHKFPSTPQD-------------VLPPANQNNFPPPPPPPPPPPLAPTLPPYQHV 1085

  Fly   587 SAAANPGLMGEAQAVASSPTSARTLPRHCYTNAA--PTKMEGNVFRYDFMEQADCPPVNRKLKPK 649
            ::.:||      ......|......|.|.....|  |....|..           ||   :..||
Zfish  1086 TSTSNP------PPPPPPPPPPPPAPIHLANQPAVLPKFFTGGF-----------PP---QKAPK 1130

  Fly   650 VAGGL-------PVVEDKPPEEFPAKPPVGVDQLTNKLGAAQLQQPIGPPSVDRKCKPNAYKLGN 707
            .:.|:       |.::..||...|..||.         .|....||  ||::     |..:.|
Zfish  1131 PSCGILPVSPVAPALQPPPPPPPPPPPPP---------PAPLKNQP--PPTL-----PKQHSL-- 1177

  Fly   708 SATMSPATRRSSGAPLSMV--LPHETDVHSPAAANAFFHETRTLPRQQHRHHPNSPGSMSVQHQR 770
            |.|: |.:.::|..| |||  |..:..|.|||..|    :|.:|..      |.||.::.|:
Zfish  1178 SKTL-PFSSQTSSVP-SMVKQLASQFPVASPALTN----QTDSLKA------PQSPPAVKVK--- 1227

  Fly   771 TASAAAAMMSLTAAAAPKQQAAAQTEHK 798
                            ||.|...|.:.:
Zfish  1228 ----------------PKWQPVGQGQQQ 1239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	31/146 (21%)
raph1b	NP_001352514.1	RA_MRL_Lpd	338..427	CDD:340553
		PH_APBB1IP	463..585	CDD:269961	31/134 (23%)