Protein Alignment dos and raph1a

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_685598.4
• Gene: raph1a / 557435
• ZFINID: ZDB-GENE-070912-156
• Length: 1346
• Species: Danio rerio
• Alignment Length: 1053
• Identity: 196/1053 - (18%)
• Similarity: 318/1053 - (30%)
• Gaps: 387/1053 - (36%)

  Fly     7 EG--WLIKSPPTKRIWRARWRRRYFTLKQGEIPEQFCLEYYTDHNCRKLKGVIDLD---QCEQVD 66
            ||  ||      |...:..|::|||.|:...|       ||....  |.|...||.   |.:.|:
Zfish   458 EGVLWL------KDDGKKSWKKRYFLLRASGI-------YYVPKG--KAKASRDLVCFLQLDHVN 507

  Fly    67 CGLRLENR---KQKFQYMFDIKTP----KRTY--YLAAETEADMRDWVNCI-------------- 108
            ..|..:.|   |....|...:|.|    |..|  ||..:....:..|||.|
Zfish   508 VYLGQDYRSKYKAPTDYCMVLKHPQIQKKSQYIKYLCCDDVRMLHQWVNGIRIAKYGKQLYVNYQ 572

  Fly   109 -----CQVCH---------LHDTKQSNELPLGAVGADENRTQHTS-SSGGLSNSTQN------TT 152
                 .:..|         :.....|:.||       |:::.|:| |..|:|.:|.:      :.
Zfish   573 EAMRRTEAAHDWSSLSSSSIKSCSSSSSLP-------ESQSNHSSQSDSGVSETTSSGHVRSQSV 630

  Fly   153 TTSLHSSAGTTAPQASVPNA---GGSAQLRRPAV-IEEQPMPSNAGNNNSDSVYVNTEYSNRETM 213
            .:|:.|.|.....||..|..   |..||..|.:. ::..|:|.:..:.:|        ||.
Zfish   631 VSSIFSEAWKRGNQADEPKMRIDGPPAQPARASYPLQLPPLPQSLQSRSS--------YSG---- 683

  Fly   214 LCDANFDQQELLSAAQQQPPPSP-----------------ATALYLNHSALIQAQAAAAAAEQLQ 261
                       :|.|....||||                 ...::..:|.|.:.|..:.|
Zfish   684 -----------VSPASPSSPPSPPPPPPPPPPLPNPTHHSTPVVFTKYSTLARLQNISQA----- 732

  Fly   262 QQQQQAARLAVSANGVVRKLPEHLVLTQQTLAEAAAQQHSSVQASPALSTASGPYIPISECF--- 323
                                |.|.   :||...||.||.:             |.:|..:|.
Zfish   733 --------------------PNHY---KQTPLLAAQQQPT-------------PPVPPPQCLKPL 761

  Fly   324 -------------SGSPRFLPGVPLPGADLAI-------PNNPTTPLNNLDPKFYDTPRSHNNIG 368
                         :..|...|.:|:||:.:|:       |.....|....||.:.     |:|..
Zfish   762 MNNTTEVASSPPPAPPPPPPPEMPVPGSAMAVLKHAPISPQYTPPPPPEEDPSYL-----HSNGY 821

  Fly   369 L---NLTNDQSYSPKITNLSLQQLANNNASKQRSDSDSESVFTDDDEWAHPLPLRENVDRSTRPS 430
            |   .......|.|.::...|||..   |.|..:.:...|....|:|...|.|:
Zfish   822 LPPPPPPEQLKYPPPLSTNGLQQFL---AQKFPNMTYDFSPVQQDEEPPPPPPV----------- 872

  Fly   431 DSSIENESFVLTYSQRFSKMPEEGGAIVPP-------AEKSSKLAGAASLPEAGDQGTLDKLAKV 488
                           .||..|::.|...||       ..:::...|....|.:....:|.....:
Zfish   873 ---------------CFSPPPQQSGPPAPPKTFTGGFPPQTAPKPGHGISPISPVPPSLSPTPSL 922

  Fly   489 LKNKNNLILDFKENEKIPRDLPQLSDTENTSPAIVARRNAHSAFI-------------------- 533
            :|.:.:|......|:. |..||:.....:.:|::.|..:...:.:
Zfish   923 MKKQQSLSSGHSPNQP-PPTLPKQYSLSSKAPSVSAPISPTQSLVKQIVNQFPDTLDGSKGPISP 986

  Fly   534 ---------------------------EESYDIPRS-------------------HQQPYYNVNQ 552
                                       |.:.:.|..                   .:.|..:.|.
Zfish   987 PVVKNKPKWQPGGQAQPQSPEFPPPPPESTLEFPPPPAPSPPPASQPSGKSGSPIKKSPSTSSNS 1051

  Fly   553 LLG----ERPVTSPHNSNPIAASTPNLMAA----DLGAVAAISAAANPGLMGEAQAVASSPT--S 607
            ..|    :.|.|...||:..|.|:.....:    ||.::...::.|.|.......:...||:  |
Zfish  1052 STGSGGKKPPPTPQRNSSMKATSSVEYQESKKVEDLVSMFGQTSQAPPSSFSTPSSTTGSPSKES 1116

  Fly   608 ARTLPRHCYTNAA--PTKMEGNVFRYDFMEQADC---------PPVNRKLKPKVAGGLPVVEDKP 661
            :|.|.:....|.|  |..::|        .|:.|         ||::.:..|..    |..|..|
Zfish  1117 SRALTKPGKINLANLPLALQG--------RQSHCRQSSADFPSPPLDCEFPPPP----PDSELLP 1169

  Fly   662 PEEFPAKPPVGVDQLTNKLGAAQLQQPIGPPSVDRKCKPNAYKLGNSATMSPAT--RRSSGAPLS 724
            |...|::..:|..::.          .:.|.........:::|..:...|.|.|  |||||.|..
Zfish  1170 PPPLPSELHIGAPKVA----------VVNPQPQHSSSSTSSWKQSSLKKMPPPTMHRRSSGPPEQ 1224

  Fly   725 MVL---PHETDVHS------PAAANA-------FFHE-TRTLPRQQHRHHPNSPGSMSVQHQRTA 772
            :.|   |.:..:.|      |.:..|       |..: .|||.|:....|    ||:      |:
Zfish  1225 LALSPPPQQMPLSSFNSQIPPTSPKANLSMQPNFLEDLNRTLKRKSMTRH----GSL------TS 1279

  Fly   773 SAAAAMMSLTAAAAPKQQAAAQTEHKLQYFDLDVTNKPPLLNRSSMSVGNLYSQGGNGASGMRFA 837
            |..:|.:...|...                |:.:...||.|.......|...|...:|.:.:|
Zfish  1280 SRISAKLEPVATMD----------------DMALPPPPPELLLGQQKKGGYTSANISGYATLR-- 1326

  Fly   838 GVEAGGARAPVPS 850
                   |.|.|:
Zfish  1327 -------RGPPPA 1332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	34/149 (23%)
raph1a	XP_685598.4	RA_MRL_Lpd	325..414	CDD:340553
		PH_APBB1IP	450..572	CDD:269961	33/128 (26%)