Protein Alignment dos and plekhs1.3

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001074034.1
• Gene: plekhs1.3 / 557029
• ZFINID: ZDB-GENE-070112-592
• Length: 421
• Species: Danio rerio
• Alignment Length: 559
• Identity: 105/559 - (18%)
• Similarity: 170/559 - (30%)
• Gaps: 215/559 - (38%)

  Fly     6 YEGWLIKSPPTKRIWR-----ARWRRRYFTLKQGEIPEQFCLEYYTDHNCR-KLKGVIDLDQCEQ 64
            |.|:|.|||.:..|.:     ..|:||:|.|.: .:.....|.||.....| |..|.|||
Zfish    23 YTGYLQKSPASPIIAKNLLSQKSWKRRFFVLSK-TVDNNHQLTYYPSSERRDKPLGKIDL----- 81

  Fly    65 VDCGLRLENRKQKFQYMF--------------DIKTP----------KRTYYLAAETEADMRDWV 105
                       .|...:|              .||.|          .|.|:|..:...|:..|:
Zfish    82 -----------SKISLLFTSPDSHPTWDWIQKHIKCPPSSVLFMTVETRDYFLIGQNSDDVDGWL 135

  Fly   106 NCICQVCHLHDTKQSNELPLGAVGADENRTQHTSSSGGLS------NSTQNTTTTSLHSSAGTTA 164
            |.|.........|.:.|.|     ..:||.:..|:....|      :..:..:..:|.|::.:|.
Zfish   136 NAIVTALKKSQCKPNTEDP-----PQDNRIRSISAPLNCSEPKVEDHHDERWSAPALMSASFSTQ 195

  Fly   165 PQASVPNAGGSAQL---RRPAVIEEQPMPSNAGNNNSDSVYVNTEYSNRETMLCDANFDQQELLS 226
            .....|.......:   |:.:|||.|...:...:.:.:.   ::||      :|.|:.  |..|.
Zfish   196 SHYDYPRKFSEPLVPAERKLSVIEIQDEKTKEKDKSPEK---SSEY------MCMASV--QIALE 249

  Fly   227 AAQQQPPPSPATALYLNHSALIQAQAAAAAAEQLQQQQQQAARLAVSANGVVRKLPEHLVLTQQT 291
            ..||:                   ::.|.|      |.....|.|...||.|         .|:|
Zfish   250 DNQQE-------------------KSTACA------QSCNDGRDASVCNGAV---------NQET 280

  Fly   292 LAEAAAQQHSSVQASPALSTASGPYIPISECFSGSPRFLPGVPLPGADLAIPNNPTTPLNNLDPK 356
                 ..|:..:....                                           .|.||:
Zfish   281 -----DDQNQKMNKEK-------------------------------------------RNSDPR 297

  Fly   357 FYDTPRSHNNIGLNLTNDQSYSPKITNLSLQQLANNNASKQRSDSDSESVFTDDDEWAHPLPLRE 421
            .:..||.||                       ..||.||.:...:.|....|:           .
Zfish   298 EHSQPRHHN-----------------------FNNNRASTELDKAPSNKSGTE-----------T 328

  Fly   422 NVDRSTRPSDSSIENESFVLTYSQRFSKMPEEGGAIVPPAEKSSKLAGAASLPEAGDQ------- 479
            :|::....|.:|::| |.|||        .:||...|....:|..    :.|...|||
Zfish   329 HVEKEICISQNSLKN-SLVLT--------EKEGKPCVSECRQSQD----SCLFHKGDQILAFNDL 380

  Fly   480 --GTLDKLAKVLK--NKNNLILDFKENEKIPRDLPQLSD 514
              .|:|::...|:  :|:.:.|..:   ::|...|..|:
Zfish   381 LIDTVDEIQTYLRRLSKDEVKLTIR---RLPGSQPLHSE 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	33/138 (24%)
plekhs1.3	NP_001074034.1	PH-like	38..138	CDD:473070	25/116 (22%)
		PDZ_canonical	<368..406	CDD:483948	8/40 (20%)