Protein Alignment dos and Raph1

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_038939789.1
• Gene: Raph1 / 363239
• RGDID: 1308387
• Length: 1318
• Species: Rattus norvegicus
• Alignment Length: 1002
• Identity: 200/1002 - (19%)
• Similarity: 306/1002 - (30%)
• Gaps: 310/1002 - (30%)

  Fly     7 EG--WLIKSPPTKRIWRARWRRRYFTLKQGEIPEQFCLEYYTDHN----CRKLKGVIDLDQCE-- 63
            ||  ||      |...:..|::|||.|:...|       ||....    .|.|...:.||...
  Rat   453 EGVLWL------KDDGKKSWKKRYFLLRASGI-------YYVPKGKAKVSRDLVCFLQLDHVNVY 504

  Fly    64 -----------QVDCGLRLENR--KQKFQYMFDIKTPKRTYYLAAETEADMRDWVNCICQVCHLH 115
                       ..||.|.|::.  ::|.||   ||      ||..:....:..|||.|      .
  Rat   505 YGQDYRNKYKAPTDCCLALKHPQIQKKSQY---IK------YLCCDDARTLHQWVNGI------R 554

  Fly   116 DTKQSNELPLG---AVGADENRTQHTS-SSGGL---SNSTQNTTTTSLHSSAGTTAPQASVPNAG 173
            ..|...:|...   |:...|:....|| ||..:   |:|:....:.|.||:...:....::|:..
  Rat   555 IAKYGKQLYTNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTLPSGH 619

  Fly   174 GSAQLRRPAVIEEQPMPSNAGNNNSDSVYVNTEYSNRE-TMLCDANFDQQELL---SAAQQQ--- 231
            ..:|....::..|   ....|....:|.....|..||. |.|......|.:::   :|:|..
  Rat   620 IRSQSTVSSIFSE---AWKRGTQLEESSKARMESMNRSYTSLMPPLSPQTKIITPYTASQPSPPL 681

  Fly   232 ---------------PPPSP-----------ATALYLNHSALIQAQAAA------------AAAE 258
                           |||.|           |..:::.:|.:.:.|.||            :|.:
  Rat   682 PPPPPPPPPPPPPPPPPPPPLPSQSAPSSGSAATMFVKYSTITRLQNAAQHSGTLFKSPAPSAMQ 746

  Fly   259 QLQQQQQQAARLAVSANGVVRKLPEHLVLTQQTLAEAAAQ------------------------- 298
            .|....|..|::.|..|||:...|.  .....|...|.||
  Rat   747 PLPLASQSKAQIVVPPNGVIPPPPP--PPPPPTPGSAMAQLKPVPCAPSLPQFSPQPPPLKIHQV 809

  Fly   299 QHSSVQASPALSTASGPYIPISECFSGSPRFLPGVPLPGADL---------AIPNNPTTPL--NN 352
            ||.. ||:|....|: |.||.:......|:.|..:| |.|..         |:|..|..|:  ..
  Rat   810 QHLP-QAAPPTPPAA-PLIPATVPPQAPPKPLVTIP-PSASTKMVSPVVAQAVPPTPAPPVPPTK 871

  Fly   353 LDPKFYDTPRSH----------NNIGLNLTNDQSY--SPKITNLS-LQQLANNNASKQRSDSDSE 404
            ..|.|   |.||          .:....|...||:  .|..:.|| :..:....||:........
  Rat   872 KQPVF---PVSHIPPTPPVQPTPHPPPTLPKQQSFGVKPPPSPLSPVPSVVKQMASQFPPPPTPP 933

  Fly   405 SVFTDDDEWAHPLPLRENVDRSTRP-SDSSIE-----NESFVLTYSQRFSKMPEEGGAIVPPAEK 463
            .|   |.:...|||      .|..| |..:::     ..|.:...|..|...|.|...:.||...
  Rat   934 PV---DSQPLKPLP------ASVTPQSPPAVKAKPKWQPSSIPAPSPDFPPPPPESSLVFPPPPP 989

  Fly   464 SSKLAGAASLPEAGDQGTLDKLAKVLKNKNNLILDFKENEKIPRDLPQLSDTENTSPAIVARRNA 528
            .:.:......|..                             |...|.:|...:.:|
  Rat   990 PAPVPPPPPPPPP-----------------------------PPPPPPVSPMASPTP-------- 1017

  Fly   529 HSAFIEESYDIPRSHQQPYYNVNQLLGERPVTSPHNSNPIAAST------PNLMAADLGAVAAIS 587
                     |...|..:....::...|::|..:|..::.|.:.:      |...:.|    :.:|
  Rat  1018 ---------DKGGSPGKKTSKMSSPGGKKPPPTPQRNSSIKSGSCAEHPEPKRPSVD----SLVS 1069

  Fly   588 AAANPGLMGEAQAVASSPTSARTLPRHCY--------------TNAAPTKMEGNVFRYDFMEQAD 638
            ..|.|...|........|.:|...|...:              .:|.|:.:.|.  ..|.:.:..
  Rat  1070 KFAPPAESGSPSKETPPPPAAPPKPGKLHLSGVNLPGIHQQGILSAKPSVLSGR--GKDAVVEFP 1132

  Fly   639 CPPVNRKLKPKVAGGLPVVE-DKPPEEFPA------KPPVGV----DQLTNKLGAAQLQQPIGPP 692
            .||.:....|..    |.:| ..||.|.||      .|.|.|    .||.:|....:...|..|.
  Rat  1133 SPPSDSDFPPPP----PEIELPLPPIEIPAVFSGNTSPKVAVVNPQPQLWSKTSVKKAPPPTRPK 1193

  Fly   693 SVD--RKCKPNAYKLGNSATMSPATRRSSGAPLSMVLPHETDVHSPAAANAFFHETRTLPRQQHR 755
            ..|  |..:.:..:.....|:.|....|..:.||:......|::            |||.|:...
  Rat  1194 RNDSTRLTQADISEQPAMTTVVPQVPTSPKSSLSVQPGFLADLN------------RTLQRKSIT 1246

  Fly   756 HHPNSPGSMSVQHQRTASAAAAMMSLTAAAAPKQQAAAQTEHKLQYFDLDVTNKPPLLNRSSMSV 820
            .|    ||:|......|...|.|                       .|:.:...||.|.......
  Rat  1247 RH----GSLSSSRMSRAEPTATM-----------------------DDMALPPPPPELLSDQQKA 1284

  Fly   821 GNLYSQGGNGASGMRFAGVEAGGARAP 847
            |    .||:..||  :|.:..|...||
  Rat  1285 G----FGGSHISG--YATLRRGPPPAP 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	32/128 (25%)
Raph1	XP_038939789.1	RA_MRL_Lpd	320..409	CDD:340553
		PH_APBB1IP	445..567	CDD:269961	34/141 (24%)