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Protein Alignment dos and Cobll1

DIOPT Version :10

Sequence 1:	NP_523890.2	Gene:	dos / 38321	FlyBaseID:	FBgn0016794	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_006499773.1	Gene:	Cobll1 / 319876	MGIID:	2442894	Length:	1274	Species:	Mus musculus

Alignment Length:	865	Identity:	178/865 - (20%)
Similarity:	292/865 - (33%)	Gaps:	233/865 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 LHDTKQSNEL------PLGAVGADENRTQHTSSSGGLSNSTQNTTTTSLHSSAGTTAPQA-SVPN 171
            |.:..:..||      |.|::..  ......|:|..:..:.:....::|..|.|.|:|.: ....
Mouse   498 LEEIDEKEELSEASKDPAGSISV--KSPDIASASTDMRITVEKDPDSALGISDGETSPSSKGKTQ 560

  Fly   172 AGGSAQLRRPAVIEEQPMPSNAGNNN--SDSVY-VNTEYSNRET------MLCDANFD------- 220
            .|.|.:.:.|    ..|:..:.||.:  |||:. :.|...|:|:      |:|..:.|
Mouse   561 EGRSTEGQGP----YHPVVGHIGNEDRVSDSIKDMKTLGPNQESVVQNEIMVCATSTDYVKNRPG 621

  Fly   221 --------QQELLSAAQQQPPP----SPATAL-YLNHSALIQAQAAAAAAEQLQQ------QQQQ 266
                    :.|.|..|......    |||..: .:..|......|:....::|.|      :.|.
Mouse   622 KMETTIEGEGEALKKASDMETDRLSGSPACRMDNVKSSRENHLTASPGPDQKLNQPGVEKTKMQD 686

  Fly   267 AARLAVSANG-------VVRKLPEHLVLTQQTLAEAAAQQHSSVQASPAL-------STASGPYI 317
            ||..|..|.|       |..........|.||...:.:.||||.....::       |..:..|:
Mouse   687 AAIQATPARGTFDGNHEVSNSSDPRADETVQTSDGSISAQHSSASLQDSVNASREFRSQGTSTYV 751

  Fly   318 ----PISE--CFSGSPRFLPGVPLPGADLAIPNNPTTPLNNL-------DPKFYDTPRSHNNIGL 369
                |..|  |..|:     .|||...|.:..|...:.|.|.       :||    |:..|.|
Mouse   752 QDRLPEKEPACTYGN-----NVPLSPVDGSNKNPAASYLKNFPLYRQDSNPK----PKPSNEI-- 805

  Fly   370 NLTNDQSYSPKITNLSLQQLANNNASKQRSDSDSESVFTDDDEWAHPLPLRENVDRSTRPSDSSI 434
                .:.|.||| .::..::....:.:...|.:||::...||:...|:..|..::..|   ::|:
Mouse   806 ----TREYIPKI-GMTTYKIVPPKSLEMAKDWESEAMGRKDDQKMLPVGQRHTIENMT---ETSM 862

  Fly   435 ENESFVLTYSQRFSKMPEEGGAIVPPAEKSSKLAGAASLPE------------AGDQGTLDKLAK 487
            :.|   :..:.:.|:.|:......|.:.....|....|.|.            ..|.||: ..|.
Mouse   863 QTE---VPATSKSSQQPQPDLKPKPSSGTERHLHRTLSSPTGTETNPPKAPRVTTDTGTI-PFAP 923

  Fly   488 VLKNKNNLI-LDFKENEKIPRDLPQ---LSDTENTSPAIV---ARRNAHSA--------FIEESY 537
            .|::.||:: ..|:.....|:..|.   |...:..|...|   |.::.|:|        .|:|..
Mouse   924 NLEDINNILESKFRSRASNPQAKPSSFFLQMQKRASGHYVTSAAAKSVHTAPGPAPKEPTIKEVQ 988

  Fly   538 DIPR--SHQQPYYNVNQLLGERPVTSPHNSNPIAASTPNLMAADLGAVAAISAAANPGLMGEAQA 600
            ..|:  ..|.|     ..|.||..::|         .||:..||...:...:..:.|       .
Mouse   989 RDPQLSPEQHP-----SSLSERTHSAP---------LPNISKADDDIIQKPAETSPP-------P 1032

  Fly   601 VASSPTSARTLPRHCYTNAAPTKMEGNVFRYDFMEQADCPPVNRKLKPKVAGGLPVVEDKPPEEF 665
            ||..|.:.|.                         :...|||..  ||..   || .|..||..|
Mouse  1033 VAPKPMTLRA-------------------------ETSPPPVFP--KPMT---LP-AETSPPPVF 1066

  Fly   666 P---------AKPPVGVDQLTNKLGAAQLQQPIGPPSVDRKCKPNAYKLGNSATMSPATRRSSGA 721
            |         :.|.|....:|       |:....||.|  ..||.|.......:::..|.::.||
Mouse  1067 PKPMTLPAETSLPLVFPKPMT-------LRAETSPPPV--AAKPVALPGSQGTSLNLKTLKTFGA 1122

  Fly   722 PLSMVLPHETDVHSPAA------ANAFFHETRTLPRQQHRHHPNSPGSMSV-----QHQRTASAA 775
            |    .|:.:...||.|      :.:|   ::..|...      |.||.::     |.::|.:..
Mouse  1123 P----RPYSSSGPSPFALAVVKRSQSF---SKACPESA------SEGSSALPPAATQDEKTHTVN 1174

  Fly   776 AAMMSLTAAAAPKQQAAAQTEHKLQYFDLDVTNKP--PLLNRSSMSVGNLYSQGGNGASGMRFAG 838
            ...:........||....|.||..|.  |...:.|  .|..:||::   ..|.............
Mouse  1175 KPTVGSQHGDGDKQNNPVQNEHSSQV--LTPADGPSFTLKRQSSLT---FQSSDPEHVRQSLLTA 1234

  Fly   839 VEAGGA-----RAPVPSSVV 853
            :.:|.|     |..|||:.:
Mouse  1235 IRSGEAAAKLKRVTVPSNTI 1254

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.