Protein Alignment dos and GRB7

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_047291813.1
• Gene: GRB7 / 2886
• HGNCID: 4567
• Length: 579
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 113/545 - (20%)
• Similarity: 170/545 - (31%)
• Gaps: 157/545 - (28%)

  Fly   162 TTAPQASVPNAGGSAQLRRPAVIEEQPMPSNAGNNNSDSVYVNT------EYSNRETMLCDANFD 220
            :::|:...|..|......||   .:.|:|...  ..|..:.:.|      |...|.|.|......
Human    11 SSSPEDLCPAPGTPPGTPRP---PDTPLPEEV--KRSQPLLIPTTGRKLREEERRATSLPSIPNP 70

  Fly   221 QQELLSAAQQQP---PPSPATAL-------------YLNHSAL--IQAQAAAAAAEQLQQQQQQA 267
            ..||.|...|.|   .||.|..|             |....|.  ::..|.|.|....:...|:|
Human    71 FPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRA 135

  Fly   268 ARLAVSANGVVRKLPEHLVLTQQTLAEAAAQQHSSVQASPALSTASG-----------PYIPISE 321
            ..|:....|:|...| ||.|      |...:.|.||....|.....|           .|    |
Human   136 HALSDETWGLVECHP-HLAL------ERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKY----E 189

  Fly   322 CFSGSPRFLPGVPLPGADLAIPNNPTTPLNNLDPKFYDTPRSHNNIGLNLTNDQSYSPKITNLSL 386
            .|..||..|           .|....:  :.||.   .|..||.::..|..|..|: |:|.....
Human   190 LFKSSPHSL-----------FPEKMVS--SCLDA---HTGISHEDLIQNFLNAGSF-PEIQGFLQ 237

  Fly   387 QQLANNNASK------QRSDSDSESVFTDDDEWAHPLPLRENVDRSTRPSDSSIENESFVLTYSQ 445
            .:.:.....|      :||.....:..|..|    |..|:...|.:        |:..:|:|..:
Human   238 LRGSGRKLWKRFFCFLRRSGLYYSTKGTSKD----PRHLQYVADVN--------ESNVYVVTQGR 290

  Fly   446 RFSKMPEEGGAIVPPAEKSSKLAGAASLPEAGDQGTLDKLA--KVLKNKNNLILDFKENEKIPRD 508
            :...||.:.|..|.|.:..:...|........:|.....||  ::.|:|
Human   291 KLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKSK---------------- 339

  Fly   509 LPQLSDTENTSPAIVA---RRNAHSAFIEESY-------------DIPRSHQ-QPYYNVNQLLGE 556
                       |.::.   ||..||..:.:|:             |:..|.. .|.|.|......
Human   340 -----------PEVIGSAHRRQKHSPGLGKSWSEGGVTATPPGPLDLKLSFSPHPQYGVQLYKNY 393

  Fly   557 RPVTSPH------NSNPIAASTPN-LMAADLGAVA---------AISAAANPGLMGEAQAVASSP 605
            :...|.|      .|.|:.:::.| |:|.|....|         |:|.|     :.||||.....
Human   394 QQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVA-----LEEAQAWRKKT 453

  Fly   606 TSARTLPRHCYTNAAPTKMEGNVFR 630
            ....:||    ..|:.|.:...:.|
Human   454 NHRLSLP----MPASGTSLSAAIHR 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535
GRB7	XP_047291813.1	RA_GRB7	100..187	CDD:340557	20/93 (22%)
		PH_APBB1IP	225..337	CDD:269961	24/124 (19%)
		BPS	412..457	CDD:462644	12/49 (24%)
		SH2_Grb7	472..579	CDD:198276	1/3 (33%)