Protein Alignment dos and GAB1

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_016863455.1
• Gene: GAB1 / 2549
• HGNCID: 4066
• Length: 738
• Species: Homo sapiens
• Alignment Length: 954
• Identity: 200/954 - (20%)
• Similarity: 327/954 - (34%)
• Gaps: 354/954 - (37%)

  Fly    24 WRRRYFTLKQGEI---PEQFCLEYYTDHNCRKLKGVIDLDQCEQVDCGLRLENRKQKFQYMFDIK 85
            |:||:|.|:.|.:   |:  .||||.:.:.:|...:|||:.|:|||.||....::.:..|:|||.
Human    13 WKRRWFVLRSGRLTGDPD--VLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDIN 75

  Fly    86 TPKRTYYLAAETEADMRDWVNCICQVCHLHDTKQSNELPLGA---VGADENRTQHTSSSGGLSNS 147
            |..|.:||.|::|.:|..||.|||.:|..:.|::....|.|:   ..||.....:|:
Human    76 TIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQAPADLPLAINTA-------- 132

  Fly   148 TQNTTTTSLHSSAGTTAPQASVPNAGGSAQLRRPAVIEEQPMPSNAGNNNSDSVYVNTEYSNRET 212
               ..:|...||:.|..|...:.|.....:   ...|:|.|.
Human   133 ---PPSTQADSSSATLPPPYQLINVPPHLE---TLGIQEDPQ----------------------- 168

  Fly   213 MLCDANFDQQELLSAAQQQPPPSPATALYLNHSALIQAQAAAAAAEQLQQQQQQAARLAVSANGV 277
                   |...|::...::|.|:              :|.::..:|:.:
Human   169 -------DYLLLINCQSKKPEPT--------------SQGSSFVSEEGE---------------- 196

  Fly   278 VRKLPEHLVLTQ--------QTLAEAAAQQHSSVQASPALSTASGPYIPISECFSGSPRFLPGVP 334
                 |:|:|..        ||.|::|....|....:..:.:...|  ..|:...|...|.
Human   197 -----EYLLLEDFESKTIPLQTHADSAKSTSSETDCNDNVPSHKNP--ASSQSKHGMNGFF---- 250

  Fly   335 LPGADLAIPNNPTT--PLNNLDPKFYDTPRSHNNIGLNLTNDQSYSPKITNLSLQQLANNNASKQ 397
               ....|.::|.:  |..::|...|:.|||:::..|         ||:             |..
Human   251 ---QQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVL---------PKV-------------SPS 290

  Fly   398 RSDSDSE-SVFTDDDEWAHPLPLRENVDRSTRPSDSSIENESFVLTYSQRFSKMPEEGGAIVPPA 461
            .:::|.| .||                  :|....||:|.:...::.|..           :||.
Human   291 STEADGELYVF------------------NTPSGTSSVETQMRHVSISYD-----------IPPT 326

  Fly   462 EKSSKLAGAASLPEAGDQGTLDKLAKVLKNKNNLILDFK----------------ENEKIPRDL- 509
            .     .....:|....:|||.:.:|:     :.|.|..                |...|||..
Human   327 P-----GNTYQIPRTFPEGTLGQTSKL-----DTIPDIPPPRPPKPHPAHDRSPVETCSIPRTAS 381

  Fly   510 --------------PQLSDTENTSPAIVARRNAHSAFIEESYDIPRSHQQP----------YYNV 550
                          |..|:|.:|......|::|.|   ::.|||||:....          ::.|
Human   382 DTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASS---QDCYDIPRAFPSDRSSSLEGFHNHFKV 443

  Fly   551 NQLLGERPVTS---PHNSNPIAASTPNLMAADLGAVAAISAAANPGLMGEAQAVASSP------- 605
            ..:|....|:|   ..|..|:..::|....:        |:...|  :.||..|..:|
Human   444 KNVLTVGSVSSEELDENYVPMNPNSPPRQHS--------SSFTEP--IQEANYVPMTPGTFDFSS 498

  Fly   606 --------------TSARTLPRHCYTNAAPTKMEGNVFRYDFMEQADC--PPVNRKLKPKVAGGL 654
                          :|.:|.||.      |..:            |||  |||:|.|||...|..
Human   499 FGMQVPPPAHMGFRSSPKTPPRR------PVPV------------ADCEPPPVDRNLKPDRKGQS 545

  Fly   655 PVVEDKPPEEFPAKPPVGVDQLTNKLGAAQLQQPIGPPSVDRKCKPNAYKLG--------NSATM 711
            |.:....|.        |:::..:        |.||..:..||.||...::.        .:...
Human   546 PKILRLKPH--------GLERTDS--------QTIGDFATRRKVKPAPLEIKPLPEWEELQAPVR 594

  Fly   712 SPATRR----SSGAPLSMVLPHETDVHS-PAAANAFFHETRTLPRQQH--RHHPNSPGSMSVQHQ 769
            ||.||.    ||..|:|   |....||| .:::::...|...:|...:  ...||..||.|:.
Human   595 SPITRSFARDSSRFPMS---PRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLD-- 654

  Fly   770 RTASAAAAMMSLTAAAAPKQQAAAQTEHKLQYFDLDV---TNKPPLLNRSSMSVGNLYSQGGNGA 831
               ..::.|:.      ||      .:.:::|.|||:   .:.||...:||          |:|
Human   655 ---GGSSPMIK------PK------GDKQVEYLDLDLDSGKSTPPRKQKSS----------GSG- 693

  Fly   832 SGMRFAGVEAGGARAPVPSSVVYRSVDFV-----KTEAFKRIRE 870
                              |||....||:|     ||.|.|..||
Human   694 ------------------SSVADERVDYVVVDQQKTLALKSTRE 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	38/93 (41%)
GAB1	XP_016863455.1	PH-like	<18..112	CDD:473070	36/95 (38%)