Protein Alignment dos and PHLDB1

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_011541005.1
• Gene: PHLDB1 / 23187
• HGNCID: 23697
• Length: 1586
• Species: Homo sapiens
• Alignment Length: 926
• Identity: 191/926 - (20%)
• Similarity: 290/926 - (31%)
• Gaps: 275/926 - (29%)

  Fly   123 LPLGAVG---------ADENRTQHTSS-SGGLSNSTQNTTTTSLHSSAGTTAPQA-SVPNAGGSA 176
            |.|||.|         ..|:...|..| ||.||      ...||.|..|.:..|: .|.....|.
Human   553 LTLGARGRRTRSPSPTLGESLAPHKGSFSGRLS------PAYSLGSLTGASPCQSPCVQRKLSSG 611

  Fly   177 QLRRPAVIEEQPMPSNAGNNNSDSVYVNTEYSNRETMLCDANFDQQELLSAAQQQPPPSPATALY 241
            .||.|...|.:...:...:|..|.:    ||..|:         :||.|...:.:..........
Human   612 DLRVPVTRERKNSITEISDNEDDLL----EYHRRQ---------RQERLREQEMERLERQRLETI 663

  Fly   242 LNHSALIQAQAAAAAAEQLQQQQQQAARLAVS----------ANGVVRKLPEHLVLTQQ--TLAE 294
            ||..|..........|.:|....:..|.||::          |:|  |...|..|.||:  ...|
Human   664 LNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGASG--RSSEEPGVATQRLWESME 726

  Fly   295 AAAQQHSSVQASPALSTASGPYIPISECFSGSPRFLPGVPLPGADLAIPNNPTTPLNN------- 352
            .:.:::...:.|...||..            .....|...|.|..||:.......|.:
Human   727 RSDEENLKEECSSTESTQQ------------EHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVR 779

  Fly   353 ---LDPKFYDTPRSHNNIGLNLTND--------QSYSPKITNLSLQQLA-NNNASKQRSDSDSE- 404
               |:.:..::.|........|..:        |.....:..|..:.:| .....|:|....:|
Human   780 VKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKERAEL 844

  Fly   405 ---------------SVFTDDDEWAHPLPLRENVDRSTRPSDSSIENESFVLTYSQRFSKMPEEG 454
                           .:.|..|..  |..:||.:....|....::|.|: .|.....|.::..|.
Human   845 AAGRRHLEARQALYAELQTQLDNC--PESVREQLQEQLRREAEALETET-KLFEDLEFQQLERES 906

  Fly   455 GAIVPPAEKSSKLAGAASLPEAGDQGTLDKLAKVL----KNKNNL-ILD----------FKENEK 504
                 ..|:..:|||         ||.|...|::|    |.|..| |||          .:|:|:
Human   907 -----RVEEERELAG---------QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESER 957

  Fly   505 IPRDLPQLSDTENTSPAIVARRNAHSAFIEESYDIPRSHQQPYYNVNQLLGERPVTSPHNSNPIA 569
            :.||       :|.|..::.:.......:|..|             :.|.|.|         |..
Human   958 LARD-------KNASLQLLQKEKEKLTVLERRY-------------HSLTGGR---------PFP 993

  Fly   570 ASTPNLMAADLGAVAAISAAANPGL--------MGEAQAVASSPTSARTLPRHCYTNAAPTKMEG 626
            .:|..|..|:|    .||.::..||        .|.:||.|||.:         .|..|.|.:..
Human   994 KTTSTLKEAEL----LISESSEMGLGTKALGLFPGSSQAGASSVS---------LTPPASTLLCP 1045

  Fly   627 NVFRYDFMEQ-------ADCPP-----------VNRKLKPKV-------AGGLPVVEDKPPEEFP 666
            ....|..:||       :..||           .:|.|.|..       :.....:...|..|..
Human  1046 KAQEYVMLEQLKVMRGTSPMPPAPVPGLSPWASASRDLVPTTCLPPMLPSSSFASITPSPKMEKL 1110

  Fly   667 AKPPVGVDQLTNKL------GAAQLQQPIGPP----SVDRKCKPNAYKLGNSATMSPATRRSSGA 721
            ..|.|.::|...:|      |.|.......||    ...|:.:....|:...|| ||..|..||
Human  1111 LLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEAT-SPLPRTRSG- 1173

  Fly   722 PL---------SMVLPHETDVHSPAAANAFFHE--TRTLPR------------------QQHRHH 757
            ||         |..|...|...||:..:|...:  |.:|||                  |:....
Human  1174 PLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESL 1238

  Fly   758 PNSP-------GSMSVQHQRTASAAAAMMSLTAAAAPKQQAAAQTE------HKLQYFDLDVTNK 809
            |..|       |...::.||...|..           ||:|||:.:      |....|....:..
Human  1239 PAEPLPTDDPAGQQVIEEQRRRLAEL-----------KQKAAAEAQCQWDALHGAAPFPAGPSGF 1292

  Fly   810 PPLLNRS---SMSVGNLYSQGGNGA--------SGMRFAGVEAGGARAPVPSSVVYRS-VDFVKT 862
            |||::.|   .:..|....:.|..|        |......:..||..|..|.::...| :|..|.
Human  1293 PPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKI 1357

  Fly   863 EAFKRIREERESSGNK 878
            |..:::.:|..:..|:
Human  1358 EEMEKMLKEAHAEKNR 1373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535
PHLDB1	XP_011541005.1	FHA_PHLB1	70..188	CDD:438765
		PHA03307	198..>592	CDD:223039	14/44 (32%)
		Smc	<731..>982	CDD:440809	51/286 (18%)
		PH_PHLDB1_2	1464..1579	CDD:270192