Protein Alignment dos and Plekhs1

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_766229.2
• Gene: Plekhs1 / 226245
• MGIID: 2443041
• Length: 474
• Species: Mus musculus
• Alignment Length: 591
• Identity: 126/591 - (21%)
• Similarity: 183/591 - (30%)
• Gaps: 212/591 - (35%)

  Fly     4 TF-YEG------WLIKSPPTKRIWR-ARWRRRYFTLKQGEIPEQFCLEYYTDHNCRKLKGVIDLD 60
            || ||.      :.|||||.:..:. ..|::|.|.|.|.. .....|.||.||..|   |.|::|
Mouse    14 TFDYENEVHKRDYFIKSPPPQLFFSGTSWKKRLFILSQSR-GTGLSLSYYKDHQHR---GSIEID 74

  Fly    61 QCEQVDCGLRLENRKQKFQYMF--------DIKTPKRTYYLAAETEADMRDWVNCICQVCHLHDT 117
            ....|:.|:..:.:.|..|.||        .|:|..|.|:|.......::|||:.:...|.
Mouse    75 GSSTVEVGINCQEKMQSVQKMFKCHPDEVMSIRTANRDYFLIGHDREKIKDWVSFMTPYCQ---- 135

  Fly   118 KQSNELPLGAVGADENRTQHTSSSGG---LSNSTQNTTTTSLHSSAGTTAPQASVPN--AGGSAQ 177
                     .|.|...|.:...|.|.   :|:.:......|:.......:|:||:|.  ...|.|
Mouse   136 ---------GVKATHQRAEEKLSLGDRRPVSDPSPFLGLCSIPEGIRLASPRASLPEHLIQKSLQ 191

  Fly   178 LRRPAVI--------------EEQ------------PMPSNAGNNNS-DSVYVNTEYSNRETMLC 215
            ..|.|.:              ||:            .:.:.||.|:| ||:..|:.
Mouse   192 RFRQAHLHQDHDFHSEPTQDTEEEYYLTPRSLEACLELENIAGPNDSGDSIESNSP--------- 247

  Fly   216 DANFDQQELLSAAQQQPPPSPATALYLNHSALIQAQAAAAAAEQLQQQQQQAARLAVSANGVVRK 280
            |..|.:.|....:.:.          |....|.::.:|:|.....|.:.|..:.|.
Mouse   248 DQGFKRAESNYVSMRS----------LRTCLLKESTSASADDNDGQAEFQTESELG--------- 293

  Fly   281 LPEHLVLTQQTLAEAAAQQHSSVQASPALSTASGPYIPISECFSGSPRFLPGVPLPGADLAIPNN 345
             |.|              |.|...:.|.||.                               ||:
Mouse   294 -PPH--------------QDSGTGSDPCLSP-------------------------------PNS 312

  Fly   346 PTTPLNNLDPKFYDTPRSHNNIGLNLTNDQSYSPKITNLSLQQLANNNASKQRSDSDSESVFTDD 410
            ..                      ..|:||..|..:|.:.|..|.||  ....|..::.:||...
Mouse   313 KA----------------------QTTDDQKGSASLTVVKLSILLNN--IPDESQVETLNVFLSP 353

  Fly   411 DEWAHPLPLREN-----VDRSTRP-------------------SDSSIENESFVLTYSQRFSKMP 451
            .:....|.|.|.     |.|...|                   ...|:|..|..||...:..|:.
Mouse   354 RDAIDYLALVEAAGQICVARWEGPPRLGCLFYHGDHILAVNDLKPQSLEEVSLFLTRCIQKEKVK 418

  Fly   452 EEGGAIVPPAEKSSKLAGAASLPEAGDQGTLDKLAKVLKNKNNLILDFKENEKIPRDLPQLSDTE 516
            ...|.| |.:||......|.||..        :||                |.:.||||:|..|.
Mouse   419 LSIGRI-PNSEKLHASPCACSLRH--------QLA----------------ESVQRDLPELERTP 458

  Fly   517 NTSPAI 522
            ..||||
Mouse   459 KRSPAI 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	38/126 (30%)
Plekhs1	NP_766229.2	PH-like	26..127	CDD:473070	31/104 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	232..251		8/27 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	272..321		16/125 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..474		10/16 (63%)