Protein Alignment dos and Gab3

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_853615.1
• Gene: Gab3 / 210710
• MGIID: 2387324
• Length: 595
• Species: Mus musculus
• Alignment Length: 588
• Identity: 131/588 - (22%)
• Similarity: 217/588 - (36%)
• Gaps: 205/588 - (34%)

  Fly     8 GWLIKSPPTKRIWRARWRRRYFTLKQGEI---PEQFCLEYYTDHNCRKLKGVIDLDQC---EQVD 66
            ||||||||.:::.|..||:|:|.|::|.:   |:  .||||.:.:..|...||||.:|   :...
Mouse    10 GWLIKSPPERKLQRYAWRKRWFVLRRGRMSGNPD--VLEYYRNKHSNKPIRVIDLSECTVWKHAG 72

  Fly    67 CG-LRLENRKQKFQYMFDIKTPKRTYYLAAETEADMRDWVNCICQVC---HLHDTKQSNE----L 123
            .| :|.|.:|   .::|.:||..||:||.|:||.:|:.||:.|.|||   ||.|...|.|    :
Mouse    73 PGFIRKEFQK---NFVFIVKTTSRTFYLVAKTEEEMQVWVHSISQVCNFSHLEDGADSMESLSHM 134

  Fly   124 P--LGAVGADENRTQHTSSSGGL-----SNST--------------------QNTTTTSLHSSAG 161
            |  .....|....|.|.::|..|     :||.                    .|..|..||
Mouse   135 PSSFQPSPASSLHTVHVANSALLKDDRNTNSVVTEETRRESEFLFLPDYLILSNCETGRLH---- 195

  Fly   162 TTAPQASVP-------NAGGS-AQLR---------RPAVIEEQPMPSNAGNNNSDSVYVNTEYS- 208
                .||:|       |:..| ||..         :|.:......|.:.|..:.|...:..:.|
Mouse   196 ----HASLPTRCDSWSNSNHSLAQTSFDDVFLDGLQPFISNNLVHPLHHGKVSQDFPSIRPQASL 256

  Fly   209 --NRETMLCDANFDQQELLSAA------------------------------QQQPPPSPATALY 241
              |||     .|...:.|:|::                              ...|||.|....|
Mouse   257 IWNRE-----INGPSRNLMSSSPLLESSLNPTVHVEEKQVSLPSGVKELNIMSNTPPPRPPKPSY 316

  Fly   242 LNHSALIQAQAAAAAAEQLQQQQQQAARLAVSANGVVRKLPEHLVLTQQTL-------------A 293
            |:                 :|:|.|......|:|    |.|.:.::.::..             .
Mouse   317 LS-----------------EQRQDQPLLTGHSSN----KKPGYTMVPRRISLSGLDHVGSWKGDV 360

  Fly   294 EAAAQQHSS--------VQASPALSTAS----GPYIPIS----------ECFSG-----SPRFLP 331
            ::.:.:|..        .:.||...|||    ..|:|:|          .|...     |...||
Mouse   361 QSQSLRHRDKRLSLNLPCKFSPIYPTASPSAEDSYVPMSPKGTASELRPHCSQDDYIPMSSSMLP 425

  Fly   332 GVPLPGADLAIPNNPTTPLNN------------LDPKFYDTPRSHNNIGLNLT---NDQSY-SPK 380
            .:|   |||..|     |:|.            ||.:...|.:.|.::....|   |..|: ||:
Mouse   426 ELP---ADLEPP-----PVNRNLKPQRKSRPPPLDSRNLSTIQEHTSLTRTYTVPCNRTSFLSPQ 482

  Fly   381 ITNLSLQQLANNNASKQRSDSDSESVFTDDDEWAHPLPLRENVDRSTRPSDSSIENESFVLTYSQ 445
            ...::..:|.:..:.::..:.:.|....:::::         :......:.||:...:  |::::
Mouse   483 RNGINCARLFSTPSEEEEEEEEEEEEEEEEEKY---------IQMEEYGTVSSLSRSA--LSWTK 536

  Fly   446 RFS 448
            :||
Mouse   537 KFS 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	48/116 (41%)
Gab3	NP_853615.1	PH_Gab3	1..125	CDD:270184	50/119 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..339		13/64 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..408		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	418..463		13/52 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..513		1/19 (5%)