Protein Alignment dos and Grb10

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001357532.1
• Gene: Grb10 / 14783
• MGIID: 103232
• Length: 621
• Species: Mus musculus
• Alignment Length: 681
• Identity: 131/681 - (19%)
• Similarity: 208/681 - (30%)
• Gaps: 229/681 - (33%)

  Fly   146 NSTQNTTTTSLHSSAGTTAPQASVPNAGGSAQLRRPAVIEEQPMPSNAGNNNSDSVYVNTEYSNR 210
            |:..|::..||:|:....:...:.|            ::|:....||.|
Mouse     2 NNDINSSVESLNSACNMQSDTDTAP------------LLEDGQHASNQG---------------- 38

  Fly   211 ETMLCDANFDQQELLSAAQQQPPPSPATALYLNHSALIQAQAAAAAAEQLQQQQQQAARLAVSAN 275
                         ..|:::.||..||...:        |.........:||::.||....::.|
Mouse    39 -------------AASSSRGQPQASPRQKM--------QRSQPVHILRRLQEEDQQLRTASLPA- 81

  Fly   276 GVVRKLPEHLVLTQQTLAEAAAQQHSSVQASPALSTASGPYIPISECFSGSPRFLPG-------- 332
             :....||        |..||.....||..|......|.|  |...| ....:::||
Mouse    82 -IPNPFPE--------LTGAAPGSPPSVAPSSLPPPPSQP--PAKHC-GRCEKWIPGENTRGNGK 134

  Fly   333 -------VPLPGADLAIPNNP------TTPLNNLDPKFYDTPRSHNNIG---------LNLTND- 374
                   .| ||..|:....|      |...:...||......:.|.:.         |.|..|
Mouse   135 RKIWRWQFP-PGFQLSKLTRPGLWTKTTARFSKKQPKNQCPTDTVNPVARMPTSQMEKLRLRKDV 198

  Fly   375 QSYSPKITNLSLQQLANNNASKQRSDSDSESVFTDDDEWA----HP-LPLRENVD--------RS 426
            :.:|...|:..::.|.:..|.........:|...||:.|.    || |.|...::        .|
Mouse   199 KVFSEDGTSKVVEILTDMTARDLCQLLVYKSHCVDDNSWTLVEHHPQLGLERCLEDHEIVVQVES 263

  Fly   427 TRPSDSSIENESFVLTYSQ-RFSKMP--------------EEGGAIVPPAEKSSKLAGAASLPEA 476
            |.||:|..   .|...|:: .|.|.|              ..||    .|:........:|.||.
Mouse   264 TMPSESKF---LFRKNYAKYEFFKNPVNFFPDQMVNWCQQSNGG----QAQLLQNFLNTSSCPEI 321

  Fly   477 GDQGTLD---------KLAKVLKNKNNLILDFKENEKIPRDLPQLSDTENTSP-AIVARRNAHSA 531
              ||.|.         |...|...::.|....|...|.||.|..|:|.|.:|. .::|.:
Mouse   322 --QGFLQVKEVGRKSWKKLYVCLRRSGLYYSTKGTSKEPRHLQLLADLEESSIFYLIAGK----- 379

  Fly   532 FIEESYDIPRSHQQPYYNVNQLLGERPVTSPHNSNPIAASTPNLMAADLGAVAAISAAANPGLMG 596
               :.|:.|..|..                        ...||....:               |.
Mouse   380 ---KQYNAPNEHGM------------------------CIKPNKAKTE---------------MK 402

  Fly   597 EAQAVASSPTSARTLPRHCYTNAAPTKMEGNVFRYDFMEQADCPPVNRKLKPKVAGGLPVVEDKP 661
            |.:.:.:.....||    |:..|.      .:.:|..:...:.....||       |||     |
Mouse   403 ELRLLCAEDEQIRT----CWMTAF------RLLKYGMLLYQNYRIPQRK-------GLP-----P 445

  Fly   662 PEEFPAKPPVGVDQLTNKLGAAQLQQPIGPPSVDRKCKPNAYKLGNSATMSPATRRSSGAPLSMV 726
            |...|.: .|..:.|.....:.|:.:.|..|:   :.:..|.:.|: |....:||.:       :
Mouse   446 PFNAPMR-SVSENSLVAMDFSGQIGRVIDNPA---EAQSAALEEGH-AWRKRSTRMN-------I 498

  Fly   727 LPHETDVHSPAAANAFFHETRTLPRQQHRHH 757
            |..::.:| |:..||..|.|      ||..|
Mouse   499 LSSQSPLH-PSTLNAVIHRT------QHWFH 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535
Grb10	NP_001357532.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118		33/177 (19%)
		RA_GRB10	197..285	CDD:340558	21/90 (23%)
		PH_APBB1IP	314..436	CDD:269961	31/180 (17%)
		BPS	452..495	CDD:462644	8/47 (17%)
		SH2_Grb10	514..621	CDD:198278	5/15 (33%)