Protein Alignment dos and Gab2

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_034378.2
• Gene: Gab2 / 14389
• MGIID: 1333854
• Length: 666
• Species: Mus musculus
• Alignment Length: 850
• Identity: 184/850 - (21%)
• Similarity: 318/850 - (37%)
• Gaps: 249/850 - (29%)

  Fly     8 GWLIKSPPTKRIWRARWRRRYFTLKQGEI---PEQFCLEYYTDHNCRKLKGVIDLDQCEQVDCGL 69
            |||.||||.|::.|..|::|:|.|:.|.:   |:  .||||.:.:.:|...:|:|:.|||||.||
Mouse    13 GWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPD--VLEYYKNEHSKKPLRIINLNLCEQVDAGL 75

  Fly    70 RLENRKQKFQYMFDIKTPKRTYYLAAETEADMRDWVNCICQVCHLHDTKQSNELPLGAVGADENR 134
            ....::.:..::|||||.:||:||.|||||||..||..|||:|..:..::|         .|..|
Mouse    76 TFNKKELQDSFVFDIKTSERTFYLVAETEADMNKWVQSICQICGFNQAEES---------TDSLR 131

  Fly   135 TQHTSSSGGLSNSTQNTTTTSLHSSAGTTAPQASVPNAGGSAQLRRPAVIEEQPMPSNAGNNNSD 199
            ...::|.|..|:..:.:::..|.....::||..|          .:|.:...:|..|:
Mouse   132 NLSSASHGPRSSPAEFSSSQHLLRERKSSAPSHS----------SQPTLFTFEPPVSS------- 179

  Fly   200 SVYVNTEYSNRETMLCDANFDQQELLSAAQQQPPPSPATALYLNHSALIQAQAAAAAAEQLQQQQ 264
                                ..|..||.:      :|...|||:               |...::
Mouse   180 --------------------HMQPTLSTS------APQEYLYLH---------------QCISRR 203

  Fly   265 QQAARLAVSANGVVRKLPEHLVLTQQTLAEAAAQQHSSVQASPALSTASGPYIPISECFSGSPRF 329
            .:.||.|..:.|..:|            ::.|.|:         |:.::|      .|.:|....
Mouse   204 TENARSASFSQGTRQK------------SDTAVQK---------LAQSNG------HCINGVGGQ 241

  Fly   330 LPGVPLPGADLAIPNNPTTPLNNLDPKFYDTPR-SHNNIGLNLTNDQSYS-PKITNLSLQQLANN 392
            :.|                        ||..|: |.:|...   .|.:|. |:    ||....:.
Mouse   242 VHG------------------------FYSLPKPSRHNTEF---KDSTYDLPR----SLASHGHT 275

  Fly   393 NASKQRSDSDSESVFTDDDEWAHPLP-----------LRENVDRSTRPSDSSIENESFVLTYSQR 446
            .:|...|::|:|.|:|      ..:|           |.:|:|..|.|..:.....:|.|..:..
Mouse   276 KSSLTGSETDNEDVYT------FKMPSNTLCRELGDLLVDNMDVPTTPLSAYQIPRTFTLDKNHN 334

  Fly   447 FSKMPEEGGAIVPPAEKSSKLAGAASLPEAGDQGTLDKLAKVLKNKNNLILDFKENEKIPRDLPQ 511
            ...:...|.:.:.|..:..|    .|..|....|::.:...:.:|..::.      ..|||
Mouse   335 AMTVATPGDSAIAPPPRPPK----PSQAETPQWGSIQQRPPISENSRSVA------ATIPR---- 385

  Fly   512 LSDTENTSPAIVARRNAHSAFIEESYDIPR--SHQQPYYNVNQLLGERPVTSPHNSNPIAASTPN 574
                .||.||:...| .|.|...|:|:.|.  |.:...::     .|.|..:....:..|:|..|
Mouse   386 ----RNTLPAMDNSR-LHRASSCETYEYPARGSGESASWS-----AEPPGKTAVGRSNSASSDDN 440

  Fly   575 LMAADLGAVAAISAAANPGLMGEAQAVASSP---------TSARTLPRHCYTNAAPTKMEGNVFR 630
            .:..:.|: :.:.|...||...::..:..||         ..:..||.|    ..|::  |:
Mouse   441 YVPMNPGS-STLLAMERPGDNSQSVYIPMSPGPHHFDPLGYPSTALPIH----RGPSR--GS--- 495

  Fly   631 YDFMEQADCPPVNRKLKP-KVAGGLP--VVEDKPPEEFPAKPPV-----GVDQLTNKLGAAQLQQ 687
                 :...|||||.||| :.|...|  :..:...:|.|.|.||     .::..|....::|..:
Mouse   496 -----EIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPVTKSWSRINSHTFNSSSSQYCR 555

  Fly   688 PIGPPSV----DRKCKPNAYKLGN--------SATMSPATRRSSGAPLSMVLPHETDVHSPAAAN 740
            ||...|:    ....:.|...:.|        |.|.|||.::|:|:...:.|..:
Mouse   556 PISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQ---------- 610

  Fly   741 AFFHETRTLPRQQHRHHPNSPGSMSVQHQRTASAAAAMMSLTAAAAPKQQAAAQTEHKLQYFDLD 805
                                |||.|...:.:.|:..:...:......|::..|......::.|:.
Mouse   611 --------------------PGSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVR 655

  Fly   806 VTNKP 810
            .:::|
Mouse   656 QSSEP 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	51/109 (47%)
Gab2	NP_034378.2	PH-like	6..128	CDD:473070	52/125 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	131..184		12/89 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..396		14/75 (19%)
		SH3-binding. /evidence=ECO:0000250	348..355		2/10 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..445		7/41 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..517		11/35 (31%)
		SH3-binding. /evidence=ECO:0000250	499..508		6/8 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..633		19/113 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	647..666		1/13 (8%)